Rv3499c - MCE-family protein mce4A

Expression: Most Significant Conditions for Rv3499c

Protein Domains

Gene Information
Locus	Rv3499c
Symbol	mce4A
Gene Name	MCE-family protein mce4A
Location	3917998 - 3919200 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1203 bp Protein:401 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	22498
Related Genes	MAP0564 MAV_0657 Mkms_4705 Mmcs_4617 MSMEG_5900 MT3603 MUL_4062 Mvan_5202 nfa5370
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3499c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3499c Transcript 1
MSGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKV
KYRGIQVGKVTDISYSGNQARLKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKT
PSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEGLRGHGDDLGA
LLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDLNTVFDNLPTINKTIVDQKDN
LNDTLLATIGLSNNAYETLAPAEQNFIDAINRLRAPLKVTSDYSPVFGCLFKGIARGVKE
FAPLIGVRKAGLFTSSSFVLGAPSYTYPESLPIVNASGGPNCRGLPDIPTKQTGGSFYRA
PFLVTDNALIPYQPFTELQVDAPSTLQFLFNGAFAERDDF*

Genomic Sequence

>Rv3499c
ATGTCCGGCGGCGGATCTCGACGCACCAGTGTCAGGGTGGCAGCGGCGCTGCTGGCCGGG
CTGATGGTGGGATCCGCAGTGCTGACTTATCTTTCGTATACGGCGGCTTTCACGTCTACG
GACACCGTCACGGTATCGTCGCCGAGGGCCGGCCTGGTTATGGAGAAGGGCGCCAAGGTC
AAATACCGTGGCATCCAGGTAGGCAAGGTCACGGATATCAGCTACAGCGGCAACCAAGCA
CGGCTCAAGCTGGCCATCGACAGCGGCGAGATGGGTTTTATCCCCTCCAACGCGACGGTG
CGCATCGCCGGAAACACCATCTTCGGCGCCAAATCGGTGGAATTCATTCCGCCAAAGACG
CCGTCGCCCAAGCCGCTAAGTCCGAATGCGCACGTGGCGGCGTCTCAGGTACAGCTTGAG
GTCAACACGTTGTTCCAATCGCTCATCGACCTGCTACACAAGATCGATCCGCTTGAAACG
AACGCGACGCTGAGCGCGCTGTCCGAAGGCCTGCGCGGCCACGGCGATGACCTGGGTGCG
CTGTTGTCGGGACTGAACACGCTGACCCGCCAAGCGAACCCAAAGTTACCCGCCCTTCAG
GAGGATTTCCGCAAGGCGGCGGTGGTGGCCAACGTCTATGCTGACGCCGCCGGGGACCTG
AACACCGTGTTCGATAACCTGCCGACGATCAACAAGACGATCGTCGACCAGAAGGACAAC
CTCAACGACACGCTGCTAGCCACCATCGGTCTGTCTAATAACGCCTATGAGACGTTGGCG
CCCGCCGAACAGAATTTCATCGACGCCATCAACCGGCTCCGAGCCCCGCTCAAAGTGACC
TCCGACTACTCCCCGGTATTCGGCTGCCTTTTCAAGGGCATCGCGCGCGGTGTCAAGGAG
TTTGCCCCGCTAATCGGTGTCCGTAAGGCTGGGCTGTTCACCTCGTCGAGCTTCGTGTTG
GGTGCGCCGTCGTACACCTATCCGGAGAGCCTGCCGATCGTCAACGCCTCCGGCGGTCCG
AACTGCCGAGGGTTGCCCGATATCCCGACCAAGCAGACGGGCGGGTCGTTCTACCGCGCG
CCGTTCCTGGTCACCGACAACGCTTTGATCCCATACCAGCCGTTCACCGAGTTACAGGTT
GACGCGCCGTCGACGCTGCAGTTCCTGTTCAACGGTGCGTTCGCGGAACGGGACGACTTC
TGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	Regulatory Rv3574	active	akankshajain.21	2012-10-05
	Co-expression (Functional linkage) authors,R. Van der Geize,K. Yam,T. Heuser,MH. Wilbrink,H. Hara,MC. Anderton,E. Sim,L. Dijkhuizen,JE. Davies,WW. Mohn,LD. Eltis A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc. Natl. Acad. Sci. U.S.A. 2007
Interaction	Regulatory Rv3574	active	akankshajain.21	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	M.smegmatis orthology based inference. Orthologous pair regulator-target found in M.smegmatis. SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008