Rv3500c - hypothetical membrane protein yrbE4B

Expression: Most Significant Conditions for Rv3500c

Protein Domains

Gene Information
Locus	Rv3500c
Symbol	yrbE4B
Gene Name	hypothetical membrane protein yrbE4B
Location	3919220 - 3920062 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:843 bp Protein:281 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	26543
Related Genes	MAP0563 MAV_0656 Mkms_4706 Mmcs_4618 MSMEG_5901 MT3604 MUL_4063 Mvan_5203 nfa5360
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3500c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3500c Transcript 1
MSYDVTIRFRRFFSRLQRPVDNFGEQALFYGETMRYVPNAITRYRKETVRLVAEMTLGAG
ALVMIGGTVGVAAFLTLASGGVIAVQGYSSLGDIGIEALTGFLSAFLNVRVVAPVIAGIA
LAATIGAGATAQLGAMRVSEEIDAVECMAVHSVSYLVSTRLIAGLVAIIPLYSLSVLAAF
FAARFTTVFVNGQSAGLYDHYFNTFLIPSDLLWSFMQAIAMSIAVMLVHTYYGYNASGGS
VGVGVAVGQAVRTSLIVVVVITLFISLAVYGASGNFNLSG*

Genomic Sequence

>Rv3500c
ATGAGCTACGACGTCACTATCCGGTTTCGCCGTTTCTTTTCGCGGCTGCAGCGGCCGGTC
GACAACTTCGGTGAGCAGGCGCTGTTCTACGGCGAAACCATGCGCTATGTGCCCAACGCC
ATCACCCGCTACCGGAAGGAGACGGTCCGGCTGGTCGCCGAGATGACGCTGGGCGCCGGA
GCGCTGGTCATGATCGGCGGCACGGTCGGGGTGGCGGCCTTTTTGACCCTGGCGTCCGGT
GGCGTGATCGCCGTGCAGGGGTATTCGTCGCTGGGCGACATCGGTATCGAGGCGTTGACC
GGGTTCCTGTCGGCGTTTTTGAACGTCCGCGTTGTCGCGCCGGTGATCGCGGGTATCGCG
CTGGCGGCCACCATCGGGGCCGGAGCCACCGCGCAGCTGGGTGCCATGCGGGTCTCTGAG
GAGATCGACGCCGTCGAATGCATGGCGGTGCACTCGGTGTCCTATTTGGTGTCAACCCGG
CTGATCGCCGGCCTGGTGGCGATCATTCCGTTGTATTCGTTGTCGGTGCTGGCCGCGTTC
TTCGCCGCTCGTTTCACCACGGTGTTCGTCAATGGGCAGTCCGCGGGCCTTTATGACCAT
TACTTCAACACCTTCCTCATCCCCTCCGACCTGTTGTGGTCGTTTATGCAAGCCATCGCT
ATGTCGATCGCGGTAATGCTGGTGCATACCTACTACGGCTACAACGCCAGCGGCGGGTCG
GTTGGGGTCGGGGTCGCGGTCGGGCAGGCCGTACGGACCTCGCTGATCGTGGTTGTTGTC
ATCACCTTGTTCATCTCGCTCGCCGTCTACGGCGCGTCCGGTAACTTCAACCTCTCGGGG
TAA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	Regulatory Rv3574	active	jgalag	2012-10-05
	Co-expression (Functional linkage) authors,R. Van der Geize,K. Yam,T. Heuser,MH. Wilbrink,H. Hara,MC. Anderton,E. Sim,L. Dijkhuizen,JE. Davies,WW. Mohn,LD. Eltis A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc. Natl. Acad. Sci. U.S.A. 2007
Interaction	Regulatory Rv3574	active	jgalag	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	PhysicalInteraction Rv0655	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) authors,SM. Joshi,AK. Pandey,N. Capite,SM. Fortune,EJ. Rubin,CM. Sassetti Characterization of mycobacterial virulence genes through genetic interaction mapping. Proc. Natl. Acad. Sci. U.S.A. 2006
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	M.smegmatis orthology based inference. Orthologous pair regulator-target found in M.smegmatis. SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008