Rv3516 - enoyl-CoA hydratase echA19

Expression: Most Significant Conditions for Rv3516

Protein Domains

Gene Information
Locus	Rv3516
Symbol	echA19
Gene Name	enoyl-CoA hydratase echA19
Location	3952544 - 3953335 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:792 bp Protein:264 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	25794
Related Genes	MAP0549c MAV_0643 Mkms_4716 Mmcs_4628 MSMEG_5915 MT3617 MUL_4076 Mvan_5216 nfa5280 SAV1245
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3516
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3516 Transcript 1
MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPDIRCCILTGAGG
YFCAGMDLKAATQKPPGDSFKDGSYGPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQ
GTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMG
LIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPENEAFKIDTQIGIKVF
LSDDAKEGPRAFAEKRAPNFQNR*

Genomic Sequence

>Rv3516
GTGGAATCCGGACCCGACGCGCTGGTGGAGCGGCGCGGCCACACCCTGATCGTGACCATG
AACCGGCCGGCCGCCCGCAACGCGCTGAGCACCGAAATGATGCGAATCATGGTGCAGGCC
TGGGATCGCGTCGACAACGATCCCGACATCCGTTGCTGCATCCTCACCGGAGCCGGTGGC
TACTTTTGCGCCGGCATGGACCTCAAGGCGGCAACCCAGAAACCGCCGGGCGACTCTTTC
AAGGACGGCAGCTACGGCCCGTCGCGCATCGATGCCCTGCTCAAAGGGCGCCGCTTGACC
AAACCGCTGATCGCCGCCGTCGAGGGGCCCGCGATCGCCGGCGGCACCGAGATCCTGCAG
GGCACCGACATCCGGGTCGCCGGTGAAAGTGCGAAGTTCGGCATCTCCGAGGCCAAGTGG
AGCCTGTACCCGATGGGCGGCTCGGCCGTGCGGCTGGTCCGGCAGATCCCCTACACTCTG
GCCTGCGACCTGCTGCTGACCGGACGGCACATTACCGCCGCCGAGGCCAAGGAAATGGGC
CTGATCGGCCACGTGGTGCCCGACGGCCAGGCGCTGACCAAGGCTCTAGAACTTGCCGAC
GCCATCTCGGCTAACGGACCCCTGGCCGTGCAGGCCATCCTGCGGTCCATCCGCGAGACC
GAGTGCATGCCCGAAAACGAGGCGTTCAAGATCGACACCCAGATCGGCATCAAGGTCTTC
CTGTCCGACGACGCCAAGGAAGGCCCGCGCGCGTTCGCCGAGAAGCGCGCACCCAACTTC
CAGAACCGCTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	Regulatory Rv3574	active	jgalag	2012-10-05
	Co-expression (Functional linkage) L. Humanes, JM. García-Fernández et al. Cloning of an ORF with homology to Mycobacterium echA1, encoding the enoyl-CoA hydratase, in Rhodococcus fascians. DNA Seq. 1999
Interaction	Regulatory Rv3574	active	jgalag	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006