Rv3536c - hydratase

Expression: Most Significant Conditions for Rv3536c

Protein Domains

Gene Information
Locus	Rv3536c
Symbol
Gene Name	hydratase
Location	3974511 - 3975296 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:786 bp Protein:262 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	13036
Related Genes	MAP0531 MAV_0625 Mkms_4749 Mmcs_4661 MSMEG_5940 MT3640 MUL_4097 Mvan_5236 nfa4650
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3536c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3536c Transcript 1
MLRDATRDELAADLAQAERSRDPIGQLTAAHPEIDVVDAYEIQLINIRQRVAEGARVVGH
KVGLSSPIMQQMMGVDEPDYGHLLDDMQVFEDTPVQASRYLSPRVEVEVGFILAADLPGA
GCTEDDVLAATEALVPAIELIDTRIKDWQIKICDTIADNASAAGFVLGAARVPPADLDVR
AIDAKLTRNGEVVAEGRSDAVLGNPATAVAWLAGKVESFGVRLRKGDIVLPGSCTFAVEA
RAGDEFVADFTGLGLVRLSFE*

Genomic Sequence

>Rv3536c
ATGCTCCGTGATGCCACCCGTGATGAGCTGGCCGCCGACCTAGCACAAGCCGAGCGAAGC
CGCGACCCGATCGGTCAACTGACCGCCGCCCATCCCGAGATCGATGTCGTCGACGCCTAC
GAGATCCAGTTGATCAACATCCGGCAGCGGGTGGCCGAGGGTGCCCGCGTGGTGGGTCAT
AAGGTCGGGCTGTCGTCGCCGATCATGCAGCAGATGATGGGGGTTGACGAACCAGACTAC
GGACACCTGCTCGACGACATGCAGGTGTTCGAAGACACGCCGGTCCAGGCGTCCCGGTAC
CTGTCTCCGCGGGTTGAGGTGGAGGTGGGCTTCATCCTGGCCGCCGACCTACCGGGTGCG
GGCTGCACCGAGGACGACGTGCTGGCGGCCACCGAGGCCCTGGTGCCCGCCATCGAGCTG
ATCGACACCAGGATCAAGGATTGGCAGATCAAGATCTGCGACACCATCGCCGACAACGCC
TCGGCGGCGGGCTTCGTGTTGGGCGCGGCCCGGGTGCCGCCGGCCGATCTTGACGTCAGG
GCGATCGATGCGAAGCTGACCCGCAACGGCGAGGTGGTGGCCGAGGGCCGCAGTGATGCG
GTGTTGGGTAACCCGGCGACCGCGGTGGCTTGGCTGGCCGGCAAGGTCGAGAGTTTCGGC
GTGCGGCTGCGCAAAGGCGACATCGTGTTACCCGGGTCATGCACGTTCGCGGTCGAGGCG
CGGGCCGGCGACGAGTTTGTCGCCGACTTCACCGGGCTGGGTTTGGTCCGGTTGTCGTTC
GAATAA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	M.smegmatis orthology based inference. Orthologous pair regulator-target found in M.smegmatis. SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Term	EC:4.2.1.- Lyases. Carbon-oxygen lyases. Hydro-lyases. - NR	active	nsampson	2012-03-05
	Automated inference of function by sequence orthology authors,R. Van der Geize,K. Yam,T. Heuser,MH. Wilbrink,H. Hara,MC. Anderton,E. Sim,L. Dijkhuizen,JE. Davies,WW. Mohn,LD. Eltis A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc. Natl. Acad. Sci. U.S.A. 2007