Rv3799c - propionyl-CoA carboxylase beta chain 4 accD4

Expression: Most Significant Conditions for Rv3799c

Protein Domains

Gene Information
Locus	Rv3799c
Symbol	accD4
Gene Name	propionyl-CoA carboxylase beta chain 4 accD4
Location	4254380 - 4255948 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1569 bp Protein:523 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33819
Related Genes	CE2704 cg3177 DIP2188 jk0139 MAP0221 MAV_0220 Mkms_5097 ML0102 Mmcs_5009 MSMEG_6391 MT3906 MUL_4982 Mvan_5639 nfa1900
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3799c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3799c Transcript 1
MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSARARIYELVDPGSFME
IGALCRTPGDPNALYGDGVVTGHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWC
AMVGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSP
IQTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEAAAYQ
YVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMAYDMHEVLLRIFDDG
DFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHMSGAIDNEASDKAARFIRFSDAFDIP
LVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQL
TADLNFAWPTARIAVIGADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAE
RGFIDAVIDPHETRLLLRKSMHLLRDKQLWWRVGRKHGLIPV*

Genomic Sequence

>Rv3799c
GTGACCGTCACCGAGCCGGTTCTGCATACCACCGCCGAGAAGCTGGCGGAGCTGCGCGAA
CGCCTGGAGTTGGCCAAGGAACCCGGCGGTGAGAAGGCCGCCGCCAAGCGCGACAAGAAG
GGCATCCCGAGTGCCCGCGCCCGCATCTACGAGCTGGTCGATCCGGGTAGCTTCATGGAG
ATCGGAGCGCTGTGCCGCACCCCCGGTGACCCCAACGCGCTCTACGGGGACGGCGTGGTC
ACCGGACATGGCCTCATCAACGGCCGGCCGGTCGGCGTGTTCTCGCACGACCAAACCGTG
TTCGGCGGCACCGTCGGGGAGATGTTTGGCCGCAAGGTGGCCCGGCTGATGGAGTGGTGC
GCGATGGTCGGCTGCCCGATCGTCGGCATCAACGACTCCGGCGGCGCCCGCATCCAAGAC
GCCGTCACCTCGCTGGCCTGGTACGCCGAGCTGGGGCGCCGCCACGAACTGCTCAGTGGG
CTGGTGCCGCAGATCTCCATCATTTTGGGCAAATGCGCTGGGGGAGCGGTGTATTCGCCG
ATCCAGACCGATCTGGTGGTGGCGGTGCGCGACCAGGGTTACATGTTCGTCACCGGCCCC
GACGTCATCAAGGACGTCACCGGTGAGGACGTCAGCCTCGACGAGCTGGGGGGCGCCGAC
CACCAGGCGAGCTACGGCAACATCCATCAGGTGGTGGAGTCCGAGGCCGCCGCATACCAG
TACGTGCGGGACTTTCTGTCGTTTCTGCCGTCCAACTGCTTCGACAAACCGCCGGTCGTC
AACCCCGGGCTGGAACCCGAAATCACCGGCCACGATCTGGAACTCGACTCGATCGTGCCG
GACTCGGACAACATGGCCTACGACATGCACGAGGTCCTGCTGCGGATCTTCGACGACGGC
GACTTCCTCGACGTCGCTGCCCAGGCCGGGCAGGCGATCATCACCGGCTACGCGCGGGTG
GACGGGCGGACCGTTGGTGTGGTGGCCAACCAGCCCATGCACATGTCGGGGGCGATCGAC
AACGAGGCGTCCGACAAGGCCGCACGGTTCATCCGGTTTAGCGACGCGTTCGACATCCCG
CTGGTGTTCGTCGTGGACACACCGGGGTTTTTGCCCGGGGTGGAACAGGAAAAGAACGGG
ATCATCAAGCGCGGTGGGAGGTTCTTGTACGCGGTGGTCGAGGCTGATGTGCCGAAGGTG
ACGATCACCATCCGCAAGTCCTACGGCGGTGCCTACGCGGTGATGGGGTCCAAGCAGCTG
ACCGCCGACCTGAACTTCGCCTGGCCCACCGCGCGCATCGCGGTGATCGGCGCCGACGGG
GCCGCGCAGTTGCTGATGAAGCGTTTCCCGGACCCGAATGCGCCGGAGGCGCAAGCGATC
CGGAAGAGCTTCGTCGAGAATTACAACCTCAACATGGCGATCCCGTGGATCGCCGCCGAG
CGCGGGTTCATCGATGCCGTCATCGACCCGCATGAGACCCGGCTGCTGTTGCGCAAGTCG
ATGCACCTGCTGCGGGACAAGCAGCTGTGGTGGCGGGTGGGCCGCAAGCACGGCCTGATC
CCGGTCTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3801c	active	sourish10	2012-10-05
	Affinity purification (Physical interaction) SK. Parker, RM. Barkley et al. Mycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatin. PLoS ONE 2009
Interaction	PhysicalInteraction Rv3281	active	jgalag	2012-10-05
	Affinity purification (Physical interaction) D. Portevin, C. de Sousa-D'Auria et al. The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv3280	active	jgalag	2012-10-05
	Affinity purification (Physical interaction) D. Portevin, C. de Sousa-D'Auria et al. The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv3285	active	jgalag	2012-10-05
	Affinity purification (Physical interaction) D. Portevin, C. de Sousa-D'Auria et al. The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv3281	active	jgalag	2012-10-05
	Affinity purification (Physical interaction) TJ. Oh, J. Daniel et al. Identification and characterization of Rv3281 as a novel subunit of a biotin-dependent acyl-CoA Carboxylase in Mycobacterium tuberculosis H37Rv. J. Biol. Chem. 2006
Interaction	PhysicalInteraction Rv3280	active	jgalag	2012-10-05
	Affinity purification (Physical interaction) TJ. Oh, J. Daniel et al. Identification and characterization of Rv3281 as a novel subunit of a biotin-dependent acyl-CoA Carboxylase in Mycobacterium tuberculosis H37Rv. J. Biol. Chem. 2006
Interaction	PhysicalInteraction Rv3285	active	jgalag	2012-10-05
	Affinity purification (Physical interaction) TJ. Oh, J. Daniel et al. Identification and characterization of Rv3281 as a novel subunit of a biotin-dependent acyl-CoA Carboxylase in Mycobacterium tuberculosis H37Rv. J. Biol. Chem. 2006
Name	BIFUNCTIONAL ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT),INVOLVED IN FATTY ACID BIOSYNTHESIS (MYCOLIC ACIDS SYNTHESIS)	active	mjackson	2012-10-05
	Claisen-type condensation
Name	BIFUNCTIONAL ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT),INVOLVED IN FATTY ACID BIOSYNTHESIS (MYCOLIC ACIDS SYNTHESIS)	active	mjackson	2012-10-05
	Claisen-type condensation
Term	EC:6.4.1.3 Propionyl-CoA carboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:4.1.1.70 Glutaconyl-CoA decarboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:6.4.1.2 Acetyl-CoA carboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:6.4.1.3 Propionyl-CoA carboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Human inference of function from sequence authors,ST. Cole,R. Brosch,J. Parkhill,T. Garnier,C. Churcher,D. Harris,SV. Gordon,K. Eiglmeier,S. Gas,CE. Barry,F. Tekaia,K. Badcock,D. Basham,D. Brown,T. Chillingworth,R. Connor,R. Davies,K. Devlin,T. Feltwell,S. Gentles,N. Hamlin,S. Holroyd,T. Hornsby,K. Jagels,A. Krogh,J. McLean,S. Moule,L. Murphy,K. Oliver,J. Osborne,MA. Quail,MA. Rajandream,J. Rogers,S. Rutter,K. Seeger,J. Skelton,R. Squares,S. Squares,JE. Sulston,K. Taylor,S. Whitehead,BG. Barrell Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998
Term	EC:4.1.1.70 Glutaconyl-CoA decarboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Human inference of function from sequence authors,ST. Cole,R. Brosch,J. Parkhill,T. Garnier,C. Churcher,D. Harris,SV. Gordon,K. Eiglmeier,S. Gas,CE. Barry,F. Tekaia,K. Badcock,D. Basham,D. Brown,T. Chillingworth,R. Connor,R. Davies,K. Devlin,T. Feltwell,S. Gentles,N. Hamlin,S. Holroyd,T. Hornsby,K. Jagels,A. Krogh,J. McLean,S. Moule,L. Murphy,K. Oliver,J. Osborne,MA. Quail,MA. Rajandream,J. Rogers,S. Rutter,K. Seeger,J. Skelton,R. Squares,S. Squares,JE. Sulston,K. Taylor,S. Whitehead,BG. Barrell Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998
Term	EC:6.4.1.2 Acetyl-CoA carboxylase. - NR	active	extern:JZUCKER	2012-03-06
	Human inference of function from sequence authors,ST. Cole,R. Brosch,J. Parkhill,T. Garnier,C. Churcher,D. Harris,SV. Gordon,K. Eiglmeier,S. Gas,CE. Barry,F. Tekaia,K. Badcock,D. Basham,D. Brown,T. Chillingworth,R. Connor,R. Davies,K. Devlin,T. Feltwell,S. Gentles,N. Hamlin,S. Holroyd,T. Hornsby,K. Jagels,A. Krogh,J. McLean,S. Moule,L. Murphy,K. Oliver,J. Osborne,MA. Quail,MA. Rajandream,J. Rogers,S. Rutter,K. Seeger,J. Skelton,R. Squares,S. Squares,JE. Sulston,K. Taylor,S. Whitehead,BG. Barrell Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998
Term	EC:6.4.1.3 Propionyl-CoA carboxylase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay D. Portevin, C. de Sousa-D'Auria et al. The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components. J. Biol. Chem. 2005
Term	EC:6.4.1.2 Acetyl-CoA carboxylase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay D. Portevin, C. de Sousa-D'Auria et al. The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components. J. Biol. Chem. 2005
Term	EC:6.4.1.4 Methylcrotonoyl-CoA carboxylase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay D. Portevin, C. de Sousa-D'Auria et al. The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components. J. Biol. Chem. 2005