Rv3800c - polyketide synthase pks13

Expression: Most Significant Conditions for Rv3800c

Protein Domains

Gene Information
Locus	Rv3800c
Symbol	pks13
Gene Name	polyketide synthase pks13
Location	4255945 - 4261146 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:5202 bp Protein:1734 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	31110
Related Genes	CE2705 CE2706 cg3178 cg3179 DIP2189 DIP2190 jk0137 jk0138 MAP0219 MAP0220 MAV_0217 MAV_0218 Mkms_5098 Mkms_5099 ML0100 ML0101 Mmcs_5010 Mmcs_5011 MSMEG_6392 MSMEG_6393 MT3907 MT3908 MUL_4983 MUL_4984 Mvan_5640 Mvan_5641 nfa1880 nfa1890 Rv3801c
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3800c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3800c Transcript 1
MADVAESQENAPAERAELTVPEMRQWLRNWVGKAVGKAPDSIDESVPMVELGLSSRDAVA
MAADIEDLTGVTLSVAVAFAHPTIESLATRIIEGEPETDLAGDDAEDWSRTGPAERVDIA
IVGLSTRFPGEMNTPEQTWQALLEGRDGITDLPDGRWSEFLEEPRLAARVAGARTRGGYL
KDIKGFDSEFFAVAKTEADNIDPQQRMALELTWEALEHARIPASSLRGQAVGVYIGSSTN
DYSFLAVSDPTVAHPYAITGTSSSIIANRVSYFYDFHGPSVTIDTACSSSLVAIHQGVQA
LRNGEADVVVAGGVNALITPMVTLGFDEIGAVLAPDGRIKSFSADADGYTRSEGGGMLVL
KRVDDARRDGDAILAVIAGSAVNHDGRSNGLIAPNQDAQADVLRRAYKDAGIDPRTVDYI
EAHGTGTILGDPIEAEALGRVVGRGRPADRPALLGAVKTNVGHLESAAGAASMAKVVLAL
QHDKLPPSINFAGPSPYIDFDAMRLKMITTPTDWPRYGGYALAGVSSFGFGGANAHVVVR
EVLPRDVVEKEPEPEPEPKAAAEPAEAPTLAGHALRFDEFGNIITDSAVAEEPEPELPGV
TEEALRLKEAALEELAAQEVTAPLVPLAVSAFLTSRKKAAAAELADWMQSPEGQASSLES
IGRSLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAGKQAPNVFSVDGPVTTGPVWVLAGFG
AQHRKMGKSLYLRNEVFAAWIEKVDALVQDELGYSVLELILDDAQDYGIETTQVTIFAIQ
IALGELLRHHGAKPAAVIGQSLGEAASAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGE
YIRLMALVEYSADEIREVFSDFPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAEGKFAR
KFATKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRYIKPGGEPIHDVEYWK
KGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVALTTADAGLHDAQLIPTLARKQD
EVSSMVSTMAQLYVYGHDLDIRTLFSRASGPQDYANIPPTRFKRKEHWLPAHFSGDGSTY
MPGTHVALPDGRHVWEYAPRDGNVDLAALVRAAAAHVLPDAQLTAAEQRAVPGDGARLVT
TMTRHPGGASVQVHARIDESFTLVYDALVSRAGSESVLPTAVGAATAIAVADGAPVAPET
PAEDADAETLSDSLTTRYMPSGMTRWSPDSGETIAERLGLIVGSAMGYEPEDLPWEVPLI
ELGLDSLMAVRIKNRVEYDFDLPPIQLTAVRDANLYNVEKLIEYAVEHRDEVQQLHEHQK
TQTAEEIARAQAELLHGKVGKTEPVDSEAGVALPSPQNGEQPNPTGPALNVDVPPRDAAE
RVTFATWAIVTGKSPGGIFNELPRLDDEAAAKIAQRLSERAEGPITAEDVLTSSNIEALA
DKVRTYLEAGQIDGFVRTLRARPEAGGKVPVFVFHPAGGSTVVYEPLLGRLPADTPMYGF
ERVEGSIEERAQQYVPKLIEMQGDGPYVLVGWSLGGVLAYACAIGLRRLGKDVRFVGLID
AVRAGEEIPQTKEEIRKRWDRYAAFAEKTFNVTIPAIPYEQLEELDDEGQVRFVLDAVSQ
SGVQIPAGIIEHQRTSYLDNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRQPD
GGWGEYVSDLEVVPIGGEHIQAIDEPIIAKVGEHMSRALGQIEADRTSEVGKQ*

Genomic Sequence

>Rv3800c
ATGGCTGACGTAGCGGAATCCCAGGAGAACGCCCCCGCCGAAAGGGCCGAGCTAACGGTC
CCCGAGATGCGCCAGTGGCTGCGCAACTGGGTGGGTAAGGCCGTCGGAAAGGCACCGGAC
TCGATCGACGAATCGGTGCCCATGGTGGAGCTGGGTCTGTCGTCGCGCGATGCCGTCGCG
ATGGCCGCCGACATAGAAGACCTGACCGGGGTCACGCTGTCGGTCGCGGTGGCGTTCGCG
CATCCGACCATCGAATCGCTGGCCACCCGGATCATCGAGGGCGAGCCGGAGACCGACCTA
GCGGGCGATGACGCCGAAGACTGGTCGCGCACCGGCCCGGCCGAGCGCGTCGACATCGCG
ATCGTGGGCTTGTCCACCCGCTTCCCGGGCGAGATGAACACCCCCGAGCAGACCTGGCAG
GCGCTGCTGGAAGGCCGCGACGGGATCACCGACCTGCCCGACGGGCGCTGGTCGGAATTC
CTCGAAGAGCCGCGGCTGGCCGCGCGGGTCGCCGGGGCCCGCACCCGGGGCGGCTACCTG
AAGGACATCAAGGGCTTCGATTCGGAGTTCTTCGCGGTGGCCAAGACCGAAGCCGACAAC
ATCGACCCGCAGCAGCGGATGGCGCTGGAGCTGACCTGGGAGGCGCTCGAGCACGCCCGC
ATCCCGGCGTCGAGCCTGCGCGGCCAGGCCGTCGGTGTGTACATCGGCAGCTCCACCAAC
GACTACAGCTTCCTGGCGGTGTCGGACCCGACGGTCGCGCACCCGTATGCGATCACCGGC
ACCAGCAGCTCGATCATCGCCAACCGGGTGTCCTACTTCTACGACTTCCACGGACCGTCG
GTCACCATTGACACCGCGTGCTCGAGTTCGCTGGTGGCCATCCACCAGGGGGTGCAGGCG
CTGCGCAACGGCGAGGCCGACGTAGTGGTCGCCGGCGGGGTGAACGCGTTGATCACACCG
ATGGTCACCCTGGGTTTCGACGAGATCGGTGCGGTGCTGGCGCCCGACGGCCGGATCAAG
TCGTTCTCAGCCGACGCCGACGGCTACACCCGCTCCGAAGGCGGCGGCATGCTGGTGCTC
AAGCGGGTCGACGACGCCCGCCGCGACGGCGACGCGATCCTGGCCGTGATCGCCGGCAGC
GCGGTCAACCACGACGGCCGGTCCAACGGCCTGATCGCACCCAACCAGGACGCGCAGGCC
GACGTGCTGCGCCGGGCCTACAAGGACGCCGGCATCGATCCGCGCACCGTCGACTACATC
GAGGCGCACGGCACCGGCACCATCCTCGGCGACCCAATCGAGGCCGAGGCGCTGGGCCGG
GTGGTCGGTAGGGGCCGTCCGGCCGATCGGCCGGCGCTGCTGGGTGCGGTGAAAACCAAC
GTCGGGCACCTGGAATCGGCGGCCGGCGCGGCCAGCATGGCCAAGGTGGTGCTGGCGCTG
CAGCACGACAAACTGCCGCCGTCGATCAACTTCGCCGGCCCCAGCCCCTACATCGACTTC
GACGCGATGCGGTTGAAGATGATCACCACGCCCACCGACTGGCCGCGATACGGCGGCTAC
GCGCTGGCCGGGGTGTCCAGCTTCGGCTTCGGCGGCGCCAACGCGCACGTGGTGGTGCGC
GAGGTCCTGCCGCGTGACGTGGTGGAAAAGGAACCGGAACCCGAGCCGGAACCCAAGGCG
GCCGCCGAACCCGCCGAGGCGCCCACGTTGGCAGGCCACGCGCTGCGGTTCGACGAGTTC
GGCAACATCATCACCGACTCGGCGGTCGCCGAAGAGCCGGAGCCCGAACTGCCCGGAGTC
ACCGAGGAGGCGCTGCGGCTCAAGGAAGCCGCGTTGGAAGAGCTTGCGGCCCAAGAGGTT
ACGGCACCATTGGTCCCGTTGGCGGTGTCGGCGTTTCTGACGTCCCGCAAGAAGGCGGCG
GCCGCCGAGTTGGCGGACTGGATGCAAAGCCCGGAAGGCCAGGCCTCCTCGCTGGAATCG
ATCGGCAGGTCGTTGTCGCGGCGCAACCACGGCCGTTCCCGCGCGGTGGTGTTGGCCCAC
GACCACGACGAGGCCATCAAGGGCCTGCGCGCGGTCGCCGCGGGCAAGCAGGCGCCGAAC
GTGTTCAGCGTCGACGGGCCGGTGACCACCGGCCCGGTCTGGGTGCTCGCCGGATTCGGC
GCCCAGCATCGCAAGATGGGCAAGAGCCTGTACCTGCGCAACGAGGTGTTCGCGGCGTGG
ATCGAGAAGGTCGACGCCCTGGTCCAAGACGAGCTGGGCTACTCGGTGCTGGAGCTGATC
CTGGACGACGCGCAGGACTACGGCATCGAGACCACCCAGGTCACCATCTTCGCGATCCAG
ATCGCGCTGGGTGAGCTGCTGCGCCATCACGGCGCCAAACCGGCCGCGGTCATCGGCCAG
TCGCTGGGTGAGGCCGCGTCGGCCTACTTCGCCGGCGGGCTGTCGCTGCGGGATGCCACC
CGGGCGATCTGCTCGCGCTCGCACCTGATGGGCGAGGGTGAGGCGATGCTGTTCGGCGAG
TACATCCGGTTGATGGCGCTGGTGGAATACTCCGCCGACGAAATCAGAGAAGTGTTCTCC
GACTTCCCCGATCTGGAGGTGTGTGTCTACGCCGCGCCCACCCAGACGGTCATCGGCGGC
CCCCCCGAGCAGGTGGACGCGATCCTTGCCCGCGCCGAGGCCGAGGGCAAGTTCGCCCGC
AAATTCGCGACCAAGGGCGCCAGCCACACCTCGCAGATGGACCCGCTGCTGGGCGAGCTC
ACCGCGGAGCTGCAAGGCATCAAGCCGACGAGCCCGACGTGTGGGATCTTCTCGACGGTG
CACGAGGGCCGCTACATCAAACCCGGCGGCGAACCCATCCACGACGTCGAATACTGGAAG
AAGGGGCTGCGGCATTCCGTCTACTTCACCCACGGCATCCGCAACGCCGTCGACAGCGGG
CACACCACCTTCCTGGAGCTGGCACCCAATCCGGTGGCGCTGATGCAGGTCGCCCTGACC
ACCGCCGATGCCGGGCTGCATGACGCCCAGTTGATCCCGACGCTGGCCCGCAAGCAAGAC
GAGGTCTCCTCGATGGTCTCGACCATGGCGCAGCTGTATGTGTACGGCCACGACCTGGAC
ATACGCACGCTGTTTAGCCGCGCCAGTGGGCCGCAGGATTACGCGAACATTCCGCCGACC
CGGTTCAAGCGCAAGGAGCACTGGCTGCCCGCGCACTTCTCCGGCGACGGCTCGACGTAC
ATGCCGGGCACCCATGTCGCCCTGCCGGATGGGCGGCACGTCTGGGAGTACGCGCCGCGG
GACGGCAATGTGGACTTGGCCGCGTTGGTCAGGGCCGCCGCCGCCCACGTGCTTCCGGAC
GCGCAACTGACCGCCGCCGAGCAGCGCGCGGTGCCCGGCGACGGCGCCCGGCTGGTGACG
ACGATGACCCGTCACCCCGGCGGCGCCTCGGTGCAGGTGCACGCCCGCATCGACGAGTCC
TTCACGCTGGTCTACGACGCCCTGGTGTCCCGAGCGGGGTCCGAATCGGTGTTGCCCACC
GCGGTGGGTGCGGCGACGGCGATCGCGGTTGCGGACGGGGCGCCTGTCGCGCCGGAAACG
CCCGCCGAAGACGCGGACGCCGAGACGCTTTCGGACAGCCTGACCACCCGTTACATGCCG
TCCGGCATGACCCGATGGTCGCCTGATTCCGGTGAGACCATCGCCGAGCGGCTGGGCCTG
ATTGTCGGGTCTGCGATGGGCTATGAGCCCGAGGACCTGCCGTGGGAGGTGCCGCTGATC
GAGCTTGGCCTGGACTCGCTGATGGCGGTGCGCATCAAAAACCGCGTCGAGTACGACTTC
GACCTGCCACCGATCCAGCTGACCGCGGTGCGCGACGCCAACCTCTACAACGTGGAGAAG
CTGATCGAATACGCGGTCGAGCACCGTGACGAGGTGCAGCAGCTGCACGAGCACCAGAAA
ACCCAGACCGCTGAGGAGATCGCGCGGGCCCAGGCCGAATTGCTGCATGGCAAGGTGGGC
AAGACCGAGCCGGTCGACTCGGAAGCCGGGGTTGCGCTCCCGTCGCCGCAAAACGGCGAG
CAGCCAAACCCGACAGGGCCCGCGCTCAACGTCGACGTGCCGCCGCGGGACGCTGCCGAG
CGGGTCACCTTCGCCACCTGGGCGATCGTCACCGGCAAGTCCCCGGGCGGCATCTTCAAC
GAGCTGCCCAGGCTGGACGACGAGGCCGCGGCCAAGATTGCGCAGCGGCTTTCCGAGCGC
GCCGAAGGCCCGATCACCGCCGAGGACGTGCTGACGTCGTCGAACATCGAGGCGCTGGCC
GACAAGGTGCGCACGTATTTGGAGGCCGGGCAGATCGATGGGTTCGTCCGCACCCTGCGG
GCGCGGCCCGAAGCAGGCGGGAAGGTGCCGGTGTTCGTGTTTCATCCGGCCGGCGGCTCG
ACGGTGGTGTACGAGCCGCTGCTGGGCCGGCTGCCGGCGGACACCCCAATGTATGGCTTC
GAACGGGTCGAGGGGTCGATCGAAGAGCGTGCACAGCAGTACGTGCCGAAGCTGATCGAG
ATGCAGGGCGACGGGCCCTATGTCCTGGTGGGTTGGTCGCTGGGCGGTGTGCTGGCCTAC
GCGTGCGCGATCGGTTTGCGGCGGCTGGGCAAGGACGTGCGGTTCGTCGGGCTGATCGAC
GCGGTGCGCGCCGGTGAGGAGATCCCGCAGACCAAGGAGGAGATCCGCAAGCGCTGGGAC
CGCTACGCCGCCTTCGCCGAGAAGACGTTCAACGTGACCATCCCGGCGATCCCGTACGAG
CAGCTCGAGGAGCTCGACGACGAGGGCCAGGTCCGGTTCGTGCTGGACGCCGTCAGCCAG
TCCGGTGTGCAGATCCCGGCCGGGATCATCGAACACCAACGCACGTCGTATCTGGACAAC
CGGGCGATCGACACCGCCCAGATCCAGCCGTACGACGGGCATGTCACCCTCTACATGGCC
GATCGCTACCATGACGACGCGATCATGTTCGAGCCCCGCTACGCCGTGCGCCAGCCGGAC
GGCGGGTGGGGCGAGTACGTTTCCGACCTCGAGGTGGTGCCGATCGGTGGCGAGCACATT
CAGGCCATCGACGAGCCGATCATCGCCAAGGTGGGCGAACACATGAGCCGCGCGTTGGGG
CAGATCGAGGCCGATCGAACAAGTGAGGTAGGCAAGCAGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3801c	active	sourish10	2012-10-05
	Affinity purification (Physical interaction) SK. Parker, RM. Barkley et al. Mycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatin. PLoS ONE 2009
Interaction	ActivatedBy Rv2794c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) C. Chalut, L. Botella et al. The nonredundant roles of two 4'-phosphopantetheinyl transferases in vital processes of Mycobacteria. Proc. Natl. Acad. Sci. U.S.A. 2006
Name	polyketide synthase 13	active	mjackson	2012-10-05
	Claisen-type condensation
Name	polyketide synthase 13	active	mjackson	2012-10-05
	Claisen-type condensation
Term	EC:2.1.1.- Transferases. Transferring one-carbon groups. Methyltransferases. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005
Term	EC:2.1.1.- Transferases. Transferring one-carbon groups. Methyltransferases. - NR	active	extern:JZUCKER	2012-03-06
	Inferred from experiment OA. Trivedi,P. Arora,V. Sridharan,R. Tickoo,D. Mohanty,RS. Gokhale Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria. Nature 2004
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay K. Takayama, C. Wang et al. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin. Microbiol. Rev. 2005