Rv3825c - polyketide synthase pks2
Protein Domains

Gene Information
LocusRv3825c
Symbolpks2
Gene Namepolyketide synthase pks2
Location4293225 - 4299605 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:6381 bp
Protein:2127 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number30229
Related GenesMT3933
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv3825c
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionTranscription Rv0757activesourish102012-10-05
Co-expression (Functional linkage)
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
InteractionTranscription Rv0757activesourish102012-10-05
Co-expression (Functional linkage)
authors,S. Adindla,L. Guruprasad Sequence analysis corresponding to the PPE and PE proteins in Mycobacterium tuberculosis and other genomes. J. Biosci. 2003
InteractionOperon Rv3824cactivesourish102012-10-05
Structural Analysis
P. Kumar, MW. Schelle et al. PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc. Natl. Acad. Sci. U.S.A. 2007
InteractionOperon Rv3824cactivesourish102012-10-05
Spectrophotometric
P. Kumar, MW. Schelle et al. PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc. Natl. Acad. Sci. U.S.A. 2007
InteractionSignaling Rv1571activerazeeth.new2012-10-05
Co-expression
AH. Li, WL. Lam et al. Bacterial artificial chromosome fingerprint arrays for the differentiation of transcriptomic differences in mycobacteria. J. Microbiol. Methods 2008
InteractionSignaling Rv1571activerazeeth.new2012-10-05
Co-expression
AH. Li, WL. Lam et al. Characterization of genes differentially expressed within macrophages by virulent and attenuated Mycobacterium tuberculosis identifies candidate genes involved in intracellular growth. Microbiology (Reading, Engl.) 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
InteractionRegulatory Rv0757activesinghpankaj21162012-10-05
Co-expression (Functional linkage)
J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
InteractionRegulatedBy Rv3911activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
S. Raman, X. Puyang et al. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J. Bacteriol. 2006
InteractionRegulatedBy Rv0348activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
NamePolyketide synthase involved in the synthesis of phthioceranic and hydroxyphthioceranic acidsactivemjackson2012-10-05
Polymethyl-branched acyltrehaloses
OtherTBPWY:Polymethyl-branched acyltrehalosesactivemjackson2012-03-05
Polyketide synthase involved in the synthesis of phthioceranic and hydroxyphthioceranic acids (phenotypic [mycobacterial recombinant strains])
TD. Sirakova, AK. Thirumala et al. The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesis. J. Biol. Chem. 2001
OtherEC:activejjmcfadden2012-03-05
Inferred from direct assay
TD. Sirakova, AK. Thirumala et al. The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesis. J. Biol. Chem. 2001