Rv3864 - conserved hypothetical protein

Expression: Most Significant Conditions for Rv3864

Protein Domains

Gene Information
Locus	Rv3864
Symbol
Gene Name	conserved hypothetical protein
Location	4340270 - 4341478 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1209 bp Protein:403 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	10697
Related Genes	MT3978
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3864
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3864 Transcript 1
MASGSGLCKTTSNFIWGQLLLLGEGIPDPGDIFNTGSSLFKQISDKMGLAIPGTNWIGQA
AEAYLNQNIAQQLRAQVMGDLDKLTGNMISNQAKYVSDTRDVLRAMKKMIDGVYKVCKGL
EKIPLLGHLWSWELAIPMSGIAMAVVGGALLYLTIMTLMNATNLRGILGRLIEMLTTLPK
FPGLPGLPSLPDIIDGLWPPKLPDIPIPGLPDIPGLPDFKWPPTPGSPLFPDLPSFPGFP
GFPEFPAIPGFPALPGLPSIPNLFPGLPGLGDLLPGVGDLGKLPTWTELAALPDFLGGFA
GLPSLGFGNLLSFASLPTVGQVTATMGQLQQLVAAGGGPSQLASMGSQQAQLISSQAQQG
GQQHATLVSDKKEDEEGVAEAERAPIDAGTAASQRGQEGTVL*

Genomic Sequence

>Rv3864
ATGGCATCGGGTAGCGGTCTTTGCAAGACGACGAGTAACTTTATTTGGGGCCAGTTACTC
TTGCTTGGAGAGGGAATCCCCGACCCAGGCGACATTTTCAACACCGGTTCGTCGCTGTTC
AAACAAATCAGCGACAAAATGGGACTCGCCATTCCGGGCACCAACTGGATCGGCCAAGCG
GCGGAAGCTTACCTAAACCAGAACATCGCGCAACAACTTCGCGCACAGGTGATGGGCGAT
CTCGACAAATTAACCGGCAACATGATCTCGAATCAGGCCAAATACGTCTCCGATACGCGC
GACGTCCTGCGGGCCATGAAGAAGATGATTGACGGTGTCTACAAGGTTTGTAAGGGCCTC
GAAAAGATTCCGCTGCTCGGCCACTTGTGGTCGTGGGAGCTCGCAATCCCTATGTCCGGC
ATCGCGATGGCCGTTGTCGGCGGCGCATTGCTCTATCTAACGATTATGACGCTGATGAAT
GCGACCAACCTGAGGGGAATTCTCGGCAGGCTGATCGAGATGTTGACGACCTTGCCAAAG
TTCCCCGGCCTGCCCGGGTTGCCCAGCCTGCCCGACATCATCGACGGCCTCTGGCCGCCG
AAGTTGCCCGACATTCCGATCCCCGGCCTGCCCGACATCCCGGGCCTACCCGACTTCAAA
TGGCCGCCCACCCCCGGCAGCCCGTTGTTCCCCGACCTCCCGTCGTTCCCAGGGTTCCCC
GGGTTCCCGGAGTTCCCCGCCATCCCCGGGTTCCCCGCACTGCCCGGGTTGCCCAGCATT
CCCAACTTGTTCCCCGGCTTGCCGGGTCTGGGCGACCTGCTGCCCGGCGTAGGCGATTTG
GGCAAGTTACCCACCTGGACTGAGCTGGCCGCTTTGCCTGACTTCTTGGGCGGCTTCGCC
GGCCTGCCCAGCTTGGGTTTTGGCAATCTGCTCAGCTTTGCCAGTTTGCCCACCGTGGGT
CAGGTGACCGCCACCATGGGTCAGCTGCAACAGCTCGTGGCGGCCGGCGGTGGCCCCAGC
CAACTGGCCAGCATGGGCAGCCAACAAGCGCAACTGATCTCGTCGCAGGCCCAGCAAGGA
GGCCAGCAGCACGCCACCCTCGTGAGCGACAAGAAGGAAGACGAGGAAGGCGTGGCCGAG
GCGGAGCGTGCACCCATCGACGCTGGCACCGCGGCCAGCCAACGGGGGCAGGAGGGGACC
GTCCTTTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3879c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,M. Sani,EN. Houben,J. Geurtsen,J. Pierson,K. de Punder,M. van Zon,B. Wever,SR. Piersma,CR. Jiménez,M. Daffé,BJ. Appelmelk,W. Bitter,N. van der Wel,PJ. Peters Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 2010
Interaction	PhysicalInteraction Rv3878	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,M. Sani,EN. Houben,J. Geurtsen,J. Pierson,K. de Punder,M. van Zon,B. Wever,SR. Piersma,CR. Jiménez,M. Daffé,BJ. Appelmelk,W. Bitter,N. van der Wel,PJ. Peters Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 2010
Interaction	PhysicalInteraction Rv3876	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,M. Sani,EN. Houben,J. Geurtsen,J. Pierson,K. de Punder,M. van Zon,B. Wever,SR. Piersma,CR. Jiménez,M. Daffé,BJ. Appelmelk,W. Bitter,N. van der Wel,PJ. Peters Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 2010
Interaction	PhysicalInteraction Rv3873	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,M. Sani,EN. Houben,J. Geurtsen,J. Pierson,K. de Punder,M. van Zon,B. Wever,SR. Piersma,CR. Jiménez,M. Daffé,BJ. Appelmelk,W. Bitter,N. van der Wel,PJ. Peters Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 2010
Interaction	PhysicalInteraction Rv3867	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,M. Sani,EN. Houben,J. Geurtsen,J. Pierson,K. de Punder,M. van Zon,B. Wever,SR. Piersma,CR. Jiménez,M. Daffé,BJ. Appelmelk,W. Bitter,N. van der Wel,PJ. Peters Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 2010
Interaction	PhysicalInteraction Rv3879c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3878	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3876	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3873	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3867	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3879c	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, K. Eiglmeier et al. Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect. Immun. 2002
Interaction	PhysicalInteraction Rv3878	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, K. Eiglmeier et al. Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect. Immun. 2002
Interaction	PhysicalInteraction Rv3876	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, K. Eiglmeier et al. Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect. Immun. 2002
Interaction	PhysicalInteraction Rv3873	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, K. Eiglmeier et al. Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect. Immun. 2002
Interaction	PhysicalInteraction Rv3867	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, K. Eiglmeier et al. Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect. Immun. 2002
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006