Rv3878 - conserved alanine rich protein

Expression: Most Significant Conditions for Rv3878

Protein Domains

Gene Information
Locus	Rv3878
Symbol
Gene Name	conserved alanine rich protein
Location	4356693 - 4357535 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:843 bp Protein:281 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	11569
Related Genes	Mkms_2513 Mmcs_2468 MSMEG_0069 MT3992 Mvan_0082
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3878
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3878 Transcript 1
MAEPLAVDPTGLSAAAAKLAGLVFPQPPAPIAVSGTDSVVAAINETMPSIESLVSDGLPG
VKAALTRTASNMNAAADVYAKTDQSLGTSLSQYAFGSSGEGLAGVASVGGQPSQATQLLS
TPVSQVTTQLGETAAELAPRVVATVPQLVQLAPHAVQMSQNASPIAQTISQTAQQAAQSA
QGGSGPMPAQLASAEKPATEQAEPVHEVTNDDQGDQGDVQPAEVVAAARDEGAGASPGQQ
PGGGVPAQAMDTGAGARPAASPLAAPVDPSTPAPSTTTTL*

Genomic Sequence

>Rv3878
ATGGCTGAACCGTTGGCCGTCGATCCCACCGGCTTGAGCGCAGCGGCCGCGAAATTGGCC
GGCCTCGTTTTTCCGCAGCCTCCGGCGCCGATCGCGGTCAGCGGAACGGATTCGGTGGTA
GCAGCAATCAACGAGACCATGCCAAGCATCGAATCGCTGGTCAGTGACGGGCTGCCCGGC
GTGAAAGCCGCCCTGACTCGAACAGCATCCAACATGAACGCGGCGGCGGACGTCTATGCG
AAGACCGATCAGTCACTGGGAACCAGTTTGAGCCAGTATGCATTCGGCTCGTCGGGCGAA
GGCCTGGCTGGCGTCGCCTCGGTCGGTGGTCAGCCAAGTCAGGCTACCCAGCTGCTGAGC
ACACCCGTGTCACAGGTCACGACCCAGCTCGGCGAGACGGCCGCTGAGCTGGCACCCCGT
GTTGTTGCGACGGTGCCGCAACTCGTTCAGCTGGCTCCGCACGCCGTTCAGATGTCGCAA
AACGCATCCCCCATCGCTCAGACGATCAGTCAAACCGCCCAACAGGCCGCCCAGAGCGCG
CAGGGCGGCAGCGGCCCAATGCCCGCACAGCTTGCCAGCGCTGAAAAACCGGCCACCGAG
CAAGCGGAGCCGGTCCACGAAGTGACAAACGACGATCAGGGCGACCAGGGCGACGTGCAG
CCGGCCGAGGTCGTTGCCGCGGCACGTGACGAAGGCGCCGGCGCATCACCGGGCCAGCAG
CCCGGCGGGGGCGTTCCCGCGCAAGCCATGGATACCGGAGCCGGTGCCCGCCCAGCGGCG
AGTCCGCTGGCGGCCCCCGTCGATCCGTCGACTCCGGCACCCTCAACAACCACAACGTTG
TAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3864	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,M. Sani,EN. Houben,J. Geurtsen,J. Pierson,K. de Punder,M. van Zon,B. Wever,SR. Piersma,CR. Jiménez,M. Daffé,BJ. Appelmelk,W. Bitter,N. van der Wel,PJ. Peters Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 2010
Interaction	PhysicalInteraction Rv3864	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3864	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, K. Eiglmeier et al. Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect. Immun. 2002
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006