Rv0018c - serine/threonine phosphatase ppp

Expression: Most Significant Conditions for Rv0018c

Protein Domains

Gene Information
Locus	Rv0018c
Symbol	ppp
Gene Name	serine/threonine phosphatase ppp
Location	21637 - 23181 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1545 bp Protein:515 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33366
Related Genes	Acel_0022 BL0585 CE0037 cg0062 DIP0057 jk0041 MAP0021c MAV_0022 Mkms_0027 ML0020 Mmcs_0019 MSMEG_0033 MT0021 MUL_0022 Mvan_0027 nfa840 PPA0187 SAV4341
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0018c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0018c Transcript 1
MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHL
DDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSR
GYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIMRALTGHEVEPTLTMREA
RAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVD
YDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRR
LAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCL
SPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLPAGTLDDAIGQLRELAANSL
LPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSAPAPTGTTPAIPTSASPAA
PASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA*

Genomic Sequence

>Rv0018c
GTGGCGCGCGTGACCCTGGTCCTGCGATACGCGGCGCGCAGCGATCGCGGCTTGGTACGC
GCCAACAACGAAGACTCGGTCTACGCTGGGGCACGGCTATTGGCCCTGGCCGACGGCATG
GGTGGGCATGCGGCCGGCGAGGTGGCGTCCCAGTTGGTGATTGCCGCATTGGCCCATCTC
GATGACGACGAGCCCGGTGGCGATCTGCTGGCCAAGCTGGATGCCGCGGTGCGCGCCGGC
AACTCGGCTATCGCAGCGCAAGTCGAGATGGAGCCCGATCTCGAAGGCATGGGTACCACG
CTCACCGCAATCCTGTTCGCGGGCAACCGGCTCGGCCTGGTGCATATCGGTGACTCGCGC
GGTTACCTGCTGCGCGACGGTGAGCTGACGCAGATCACCAAGGACGACACGTTTGTCCAA
ACGCTGGTCGACGAAGGCCGGATCACCCCGGAGGAGGCGCACAGCCACCCGCAACGCTCG
TTGATCATGCGGGCGTTGACCGGCCATGAGGTCGAACCGACGCTGACCATGCGAGAAGCC
CGCGCCGGTGATCGTTACCTGCTGTGCTCGGACGGGTTGTCCGATCCGGTTAGCGATGAA
ACTATCCTCGAGGCCCTGCAGATCCCCGAGGTTGCCGAGAGCGCTCACCGCCTCATTGAA
CTGGCGCTGCGCGGCGGCGGCCCCGACAACGTCACTGTCGTCGTCGCCGACGTCGTCGAC
TACGACTACGGCCAGACCCAACCGATTCTGGCCGGGGCGGTCTCAGGCGACGACGACCAA
CTGACCCTGCCCAACACCGCCGCCGGCCGGGCCTCTGCCATCAGCCAGCGCAAGGAGATC
GTTAAACGCGTTCCGCCACAGGCCGATACATTCAGTCGGCCACGGTGGTCGGGCCGACGG
CTAGCATTCGTTGTCGCACTGGTGACCGTGCTGATGACTGCGGGCCTGCTCATTGGTCGC
GCGATCATCCGCAGCAACTACTACGTAGCGGACTACGCCGGCAGCGTGTCCATCATGCGG
GGGATTCAAGGGTCGCTACTGGGCATGTCCCTGCACCAGCCTTACCTGATGGGCTGCCTC
AGCCCGCGTAACGAGCTGTCGCAGATCAGCTACGGACAGTCTGGGGGCCCTCTCGACTGC
CATCTGATGAAACTGGAGGATCTGCGACCGCCGGAGCGCGCACAGGTTCGGGCCGGTCTC
CCGGCCGGCACTCTCGATGACGCCATCGGGCAGTTGCGCGAACTGGCGGCCAACTCCCTG
CTGCCGCCTTGCCCGGCGCCGCGTGCCACGTCCCCGCCCGGGCGCCCGGCCCCACCCACC
ACCAGCGAGACAACCGAACCAAACGTCACCTCCTCGCCAGCCTCTCCATCACCCACCACC
TCCGCGCCGGCCCCCACCGGAACTACTCCTGCCATCCCCACGAGTGCCTCCCCGGCAGCG
CCCGCGTCGCCGCCGACGCCTTGGCCCGTCACCAGCTCGCCGACGATGGCCGCACTTCCG
CCACCCCCGCCTCAGCCGGGCATCGACTGCCGGGCGGCGGCATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Activates Rv1222	active	harsharohiratruefriend	2012-10-05
	mass spectrometry R. Manganelli,R. Provvedi,S. Rodrigue,J. Beaucher,L. Gaudreau,I. Smith,R. Proveddi Sigma factors and global gene regulation in Mycobacterium tuberculosis. J. Bacteriol. 2004
Interaction	Activates Rv1222	active	harsharohiratruefriend	2012-10-05
	mass spectrometry S. Barik, K. Sureka et al. RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. Mol. Microbiol. 2010
Interaction	Signaling Rv0014c	active	vmevada102	2012-10-05
	Spectrophotometric Analysis B. Boitel, M. Ortiz-Lombardía et al. PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol. Microbiol. 2003
Interaction	Signaling Rv0015c	active	vmevada102	2012-10-05
	Spectrophotometric Analysis B. Boitel, M. Ortiz-Lombardía et al. PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol. Microbiol. 2003
Interaction	Signaling Rv0014c	active	vmevada102	2012-10-05
	Spectrophotometric Analysis P. Chopra, B. Singh et al. Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine-threonine kinases PknA and PknB. Biochem. Biophys. Res. Commun. 2003
Interaction	Signaling Rv0015c	active	vmevada102	2012-10-05
	Spectrophotometric Analysis P. Chopra, B. Singh et al. Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine-threonine kinases PknA and PknB. Biochem. Biophys. Res. Commun. 2003
Name	phosphoserine/threonine phosphatase, known to dephosphorylate KasA, KasB, FabH, InhA and Pks13	active	mjackson	2012-10-05
	Regulatory proteins
Symbol	pstP	active	mjackson	2012-10-05
	Regulatory proteins