Rv0054 - single-strand binding protein ssb

Expression: Most Significant Conditions for Rv0054

Protein Domains

Gene Information
Locus	Rv0054
Symbol	ssb
Gene Name	single-strand binding protein ssb
Location	58586 - 59080 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:495 bp Protein:165 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	36997
Related Genes	CE2819 cg3307 DIP2290 jk2065 MAP0068 Mkms_5458 ML2684 Mmcs_5369 MSMEG_6896 MT0060 MUL_0072 Mvan_6033 nfa55730
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0054
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0054 Transcript 1
MAGDTTITIVGNLTADPELRFTPSGAAVANFTVASTPRIYDRQTGEWKDGEALFLRCNIW
REAAENVAESLTRGARVIVSGRLKQRSFETREGEKRTVIEVEVDEIGPSLRYATAKVNKA
SRSGGFGSGSRPAPAQTSSASGDDPWGSAPASGSFGGGDDEPPF*

Genomic Sequence

>Rv0054
GTGGCTGGTGACACCACCATCACCATCGTCGGAAATCTGACCGCTGACCCCGAGCTGCGG
TTCACCCCGTCCGGTGCGGCCGTGGCGAATTTCACCGTGGCGTCAACGCCCCGGATCTAT
GACCGTCAGACCGGCGAATGGAAAGACGGCGAAGCGCTGTTCCTCCGGTGCAATATCTGG
CGGGAGGCGGCCGAGAACGTGGCCGAGAGCCTCACCCGGGGGGCACGAGTCATCGTTAGC
GGGCGGCTTAAGCAGCGGTCGTTTGAAACCCGTGAGGGCGAGAAGCGCACCGTCATCGAG
GTCGAGGTCGATGAGATTGGGCCTTCGCTTCGGTACGCCACCGCCAAGGTCAACAAGGCC
AGCCGCAGCGGCGGGTTTGGCAGCGGATCCCGTCCGGCGCCGGCGCAGACCAGCAGCGCC
TCGGGAGATGACCCGTGGGGCAGCGCACCGGCGTCGGGTTCGTTCGGCGGCGGCGATGAC
GAACCGCCATTCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv0182c	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) JH. Lee, DE. Geiman et al. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J. Bacteriol. 2008
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Other	TBPWY:General/ regulation	active	vmizrahi	2012-03-05
	Structure determined
Other	TBPWY:General/ regulation	active	vmizrahi	2012-03-05
	Over-expressed and biochemically characterized
Other	TBPWY:General/ regulation	active	vmizrahi	2012-03-05
	Characterization of amino acid residues essential for tetramer formation and DNA-binding activity. E62G, D104N, E94G/T137N, and S130P/G153N were found to totally or partially lose their ability to form tetramer. E62G, D104N, and E94G/T134N found to have a much lower ssDNA-binding activity, and F21L found to have a significantly higher activity