Rv0211 - iron-regulated phosphoenolpyruvate carboxykinase pckA

Expression: Most Significant Conditions for Rv0211

Protein Domains

Gene Information
Locus	Rv0211
Symbol	pckA
Gene Name	iron-regulated phosphoenolpyruvate carboxykinase pckA
Location	251782 - 253602 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1821 bp Protein:607 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	19008
Related Genes	CE2691 cg3169 DIP2180 jk0151 MAP3646 MAV_4963 Mkms_0185 ML2624 Mmcs_0176 MSMEG_0255 MT0221 MUL_1101 Mvan_0201 nfa54790 SAV3287
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0211
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0211 Transcript 1
MTSATIPGLDTAPTNHQGLLSWVEEVAELTQPDRVVFTDGSEEEFQRLCDQLVEAGTFIR
LNPEKHKNSYLALSDPSDVARVESRTYICSAKEIDAGPTNNWMDPGEMRSIMKDLYRGCM
RGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMTRMGKAALEKMGDDGFFVKAL
HSVGAPLEPGQKDVAWPCSETKYITHFPETREIWSYGSGYGGNALLGKKCYSLRIASAMA
HDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKTNLAMLQPTIPGWRAETLGDDIAWM
RFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMRTIAAGNTVFTNVALTDDGDVWWEGLE
GDPQHLIDWKGNDWYFRETETNAAHPNSRYCTPMSQCPILAPEWDDPQGVPISGILFGGR
RKTTVPLVTEARDWQHGVFIGATLGSEQTAAAEGKVGNVRRDPMAMLPFLGYNVGDYFQH
WINLGKHADESKLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWIVDRIEHKAGGATTPI
GTVPAVEDLDLDGLDVDAADVAAALAVDADEWRQELPLIEEWLQFVGEKLPTGVKDEFDA
LKERLG*

Genomic Sequence

>Rv0211
ATGACCTCAGCGACCATCCCCGGTCTGGATACCGCGCCGACGAATCACCAGGGGTTGCTG
TCCTGGGTCGAAGAGGTCGCCGAGCTCACCCAGCCGGACCGGGTGGTCTTCACTGACGGC
TCGGAAGAAGAGTTCCAGCGGCTCTGCGATCAGCTAGTCGAGGCCGGCACGTTCATCAGG
CTCAACCCCGAGAAGCACAAGAACTCCTACCTGGCATTGTCGGATCCGTCCGATGTCGCG
CGGGTGGAGTCGCGGACGTACATCTGCTCGGCGAAAGAGATCGACGCCGGCCCCACCAAC
AACTGGATGGATCCCGGCGAAATGCGGTCCATCATGAAAGACCTGTACCGGGGTTGCATG
CGCGGGCGCACCATGTATGTGGTGCCGTTCTGTATGGGACCGCTGGGCGCCGAGGACCCC
AAACTTGGTGTGGAGATCACCGACTCCGAGTACGTCGTCGTCTCCATGCGCACCATGACC
CGGATGGGCAAGGCCGCGCTGGAGAAAATGGGCGACGACGGTTTCTTTGTCAAGGCGCTG
CACTCGGTCGGCGCGCCGCTGGAACCGGGCCAAAAGGACGTGGCCTGGCCCTGCAGCGAA
ACCAAGTACATCACCCACTTCCCGGAGACCCGGGAGATCTGGAGCTACGGCTCGGGCTAC
GGCGGCAACGCGTTGCTGGGCAAGAAGTGCTACTCACTGCGTATCGCGTCGGCGATGGCC
CACGATGAGGGCTGGCTGGCCGAGCACATGCTGATCCTCAAGCTGATTTCGCCGGAGAAC
AAGGCTTACTACTTCGCGGCCGCATTCCCGTCGGCGTGTGGCAAGACCAACCTGGCGATG
CTGCAGCCAACCATCCCCGGCTGGCGTGCGGAGACACTCGGAGACGACATCGCATGGATG
CGATTTGGCAAGGACGGTCGCCTGTACGCCGTCAACCCGGAATTCGGCTTCTTCGGGGTG
GCGCCGGGCACCAACTGGAAGTCGAACCCTAACGCCATGCGCACCATTGCCGCCGGCAAC
ACGGTGTTCACCAATGTCGCACTCACCGACGACGGCGACGTGTGGTGGGAGGGCCTGGAA
GGCGACCCGCAGCACCTGATCGACTGGAAGGGCAACGACTGGTACTTCCGCGAGACGGAA
ACCAATGCGGCACACCCGAACTCCCGGTACTGCACACCGATGTCGCAGTGCCCGATCCTG
GCCCCCGAGTGGGATGACCCGCAGGGCGTCCCGATCTCGGGGATCCTGTTCGGCGGCCGC
CGCAAGACCACGGTTCCGCTGGTCACCGAGGCGCGCGACTGGCAGCACGGGGTGTTCATC
GGTGCGACCCTGGGTAGCGAGCAGACCGCCGCGGCCGAGGGCAAGGTCGGCAATGTGCGC
CGCGACCCGATGGCCATGCTGCCGTTTTTGGGCTACAACGTTGGGGACTACTTCCAGCAC
TGGATCAACCTGGGCAAGCACGCCGATGAGTCCAAGCTGCCCAAGGTGTTCTTCGTCAAC
TGGTTCCGTCGCGGTGACGACGGTCGCTTCCTGTGGCCGGGCTTCGGCGAGAACAGCCGG
GTGCTGAAGTGGATCGTCGATCGCATCGAGCACAAGGCCGGCGGTGCGACCACCCCGATC
GGCACCGTTCCCGCCGTGGAGGACTTGGACCTGGACGGACTGGACGTCGACGCCGCCGAT
GTAGCCGCGGCGCTGGCAGTCGATGCCGATGAATGGCGTCAGGAACTGCCGCTGATCGAA
GAATGGCTGCAGTTCGTCGGCGAGAAGCTGCCGACCGGTGTCAAAGATGAGTTCGACGCC
CTGAAGGAGCGCCTAGGTTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:PPCKr phosphoenolpyruvate carboxykinase - ISS	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,SW. Park,EH. Hwang,H. Park,JA. Kim,J. Heo,KH. Lee,T. Song,E. Kim,YT. Ro,SW. Kim,YM. Kim Growth of mycobacteria on carbon monoxide and methanol. J. Bacteriol. 2003
Term	EC:4.1.1.49 Phosphoenolpyruvate carboxykinase (ATP). - ISS	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,SW. Park,EH. Hwang,H. Park,JA. Kim,J. Heo,KH. Lee,T. Song,E. Kim,YT. Ro,SW. Kim,YM. Kim Growth of mycobacteria on carbon monoxide and methanol. J. Bacteriol. 2003
Term	TBRXN:PPCKr phosphoenolpyruvate carboxykinase - ISS	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,V. Srinivasan,HJ. Morowitz Ancient genes in contemporary persistent microbial pathogens. Biol. Bull. 2006
Term	EC:4.1.1.49 Phosphoenolpyruvate carboxykinase (ATP). - ISS	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,V. Srinivasan,HJ. Morowitz Ancient genes in contemporary persistent microbial pathogens. Biol. Bull. 2006
Term	TBRXN:PEPCK_re phosphoenolpyruvate carboxykinase (GTP) - IPI	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,SW. Park,EH. Hwang,H. Park,JA. Kim,J. Heo,KH. Lee,T. Song,E. Kim,YT. Ro,SW. Kim,YM. Kim Growth of mycobacteria on carbon monoxide and methanol. J. Bacteriol. 2003
Term	EC:4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP). - IPI	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,SW. Park,EH. Hwang,H. Park,JA. Kim,J. Heo,KH. Lee,T. Song,E. Kim,YT. Ro,SW. Kim,YM. Kim Growth of mycobacteria on carbon monoxide and methanol. J. Bacteriol. 2003
Term	TBRXN:PEPCK_re phosphoenolpyruvate carboxykinase (GTP) - IPI	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,V. Srinivasan,HJ. Morowitz Ancient genes in contemporary persistent microbial pathogens. Biol. Bull. 2006
Term	EC:4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP). - IPI	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,V. Srinivasan,HJ. Morowitz Ancient genes in contemporary persistent microbial pathogens. Biol. Bull. 2006
Term	TBRXN:PEPCK_re phosphoenolpyruvate carboxykinase (GTP) - ISS	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,SW. Park,EH. Hwang,H. Park,JA. Kim,J. Heo,KH. Lee,T. Song,E. Kim,YT. Ro,SW. Kim,YM. Kim Growth of mycobacteria on carbon monoxide and methanol. J. Bacteriol. 2003
Term	EC:4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP). - ISS	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,SW. Park,EH. Hwang,H. Park,JA. Kim,J. Heo,KH. Lee,T. Song,E. Kim,YT. Ro,SW. Kim,YM. Kim Growth of mycobacteria on carbon monoxide and methanol. J. Bacteriol. 2003
Term	TBRXN:PEPCK_re phosphoenolpyruvate carboxykinase (GTP) - ISS	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,V. Srinivasan,HJ. Morowitz Ancient genes in contemporary persistent microbial pathogens. Biol. Bull. 2006
Term	EC:4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP). - ISS	active	njamshidi	2012-10-05
	Made rev due to suggestions in lit for mtb to carry out carbon fixation. PMID: 16501059, 12486050 authors,V. Srinivasan,HJ. Morowitz Ancient genes in contemporary persistent microbial pathogens. Biol. Bull. 2006
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	RegulatedBy Rv0182c	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. JH. Lee, DE. Geiman et al. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J. Bacteriol. 2008
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
Term	EC:4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP). - NR	active	extern:JZUCKER	2012-03-06
	Inferred from mutant phenotype J. Marrero,KY. Rhee,D. Schnappinger,K. Pethe,S. Ehrt Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection. Proceedings of the National Academy of Sciences of the United States of America 2010
Term	EC:4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP). - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011