Rv0469 - mycolic acid synthase umaA

Expression: Most Significant Conditions for Rv0469

Protein Domains

Gene Information
Locus	Rv0469
Symbol	umaA
Gene Name	mycolic acid synthase umaA
Location	559888 - 560748 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:861 bp Protein:287 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	34018
Related Genes	MAP3963 MAP3964c MAV_4679 MAV_4680 ML2459 MSMEG_0902 MSMEG_0913 MT0486 MT0673 MUL_4538 MUL_4539 Mvan_0803 Rv0470c Rv0645c
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0469
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0469 Transcript 1
MTELRPFYEESQSIYDVSDEFFSLFLDPTMAYTCAYFEREDMTLEEAQNAKFDLALDKLH
LEPGMTLLDIGCGWGGGLQRAIENYDVNVIGITLSRNQFEYSKAKLAKIPTERSVQVRLQ
GWDEFTDKVDRIVSIGAFEAFKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQMHEMG
VKVTMSDVRFMKFIGEEIFPGGQLPAQEDIFKFAQAADFSVEKVQLLQQHYARTLNIWAA
NLEANKDRAIALQSEEIYNKYMHYLTGCEHFFRKGISNVGQFTLTK*

Genomic Sequence

>Rv0469
ATGACTGAGTTAAGGCCCTTTTACGAAGAGTCGCAATCGATTTACGACGTTTCCGACGAG
TTTTTCTCACTGTTTCTAGACCCCACGATGGCTTACACCTGCGCGTACTTCGAGCGTGAG
GACATGACTCTCGAAGAAGCGCAAAACGCGAAGTTCGATTTGGCGCTGGACAAGTTGCAT
CTTGAGCCCGGGATGACGCTGCTCGATATTGGCTGCGGCTGGGGTGGTGGGCTGCAACGA
GCGATCGAGAACTACGATGTGAACGTCATCGGTATCACGCTCAGTCGCAATCAGTTCGAG
TACAGCAAAGCGAAATTGGCGAAAATTCCCACCGAACGCAGCGTCCAGGTGCGGCTGCAG
GGCTGGGATGAGTTCACGGACAAGGTCGACCGTATTGTCAGCATCGGTGCCTTCGAAGCA
TTCAAAATGGAGCGTTATGCGGCATTCTTTGAGCGTTCCTACGACATACTTCCAGATGAC
GGCCGGATGCTGCTGCACACAATTCTGACCTATACGCAGAAGCAGATGCATGAGATGGGC
GTCAAGGTGACGATGAGCGATGTGCGGTTTATGAAATTCATCGGCGAAGAAATTTTTCCG
GGCGGACAGTTACCGGCGCAGGAAGACATCTTCAAATTTGCGCAGGCGGCGGACTTTTCG
GTGGAGAAGGTGCAATTGCTGCAGCAGCATTACGCTCGGACGCTAAACATCTGGGCGGCG
AATCTGGAGGCTAACAAGGACCGCGCCATTGCTCTTCAGTCCGAGGAGATTTACAACAAA
TACATGCACTATCTGACCGGATGTGAGCACTTCTTCCGCAAGGGCATCAGCAACGTGGGA
CAGTTCACACTGACCAAGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	RegulatedBy Rv3833	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv3416	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv2175c	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Name	POSSIBLE MYCOLIC ACID SYNTHASE UmaA, KO of the TB gene shows no phenotype, whereas KO of the M. smegmatis gene results in altered mycolates: still controversial	active	mjackson	2012-10-05
	S-adenosyl-methionine-dependent mycolic acid methyltransferases
Symbol	umaA1	active	mjackson	2012-10-05
	S-adenosyl-methionine-dependent mycolic acid methyltransferases
Name	POSSIBLE MYCOLIC ACID SYNTHASE UmaA, KO of the TB gene shows no phenotype, whereas KO of the M. smegmatis gene results in altered mycolates: still controversial	active	mjackson	2012-10-05
	S-adenosyl-methionine-dependent mycolic acid methyltransferases
Symbol	umaA1	active	mjackson	2012-10-05
	S-adenosyl-methionine-dependent mycolic acid methyltransferases