Rv0594 - MCE-family protein mce2F

Expression: Most Significant Conditions for Rv0594

Protein Domains

Gene Information
Locus	Rv0594
Symbol	mce2F
Gene Name	MCE-family protein mce2F
Location	693237 - 694787 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1551 bp Protein:517 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	20981
Related Genes	MAP3609 MAP4089 MAV_4546 MAV_5010 Mkms_0132 ML2594 Mmcs_0123 MSMEG_0139 MT0183 MT0624 MUL_1067 Mvan_0139 Rv0174
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0594
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0594 Transcript 1
MLTRAIKTQLVLLTVLAVIAVVVLGWYFLRIPSLVGIGRYTLYAELPRSGGLYRTANVTY
RGITIGKVTGVEPTERGARATMSIDNGYQIPTDASANVHSVSAVGEQFVDLVSTRTSGPY
LRHGQTITTTTVPSQIGPALDAANRGLAVLPKDRVASVLHEASEAVGGLGSSLNRLIEAT
QAIAHDVRGSLEDIDDIIERSAPIIDSQVNSGNEIARWAANLNTLAAQTAQTDPAVRSIL
ANAAPTADQVNATFSDVRESLPQTLANLEVVIDMLKRYHNGVEQALVFLPQSGAIAQSVT
TEFPGQAGLGVGGLALNQPPPCLTGFLPASEWRSPADTSTAPLPKGTYCRIPMDASNVVR
GARNNPCVDVPGKRAATPRECRSNEAYVPGGTNPWYGDPNQMLSCPAPAARCDQPVKPGQ
VIPAPSVNNGINPLPADQLPGTPPPVNDPLQRPGSGTVQCNGQQPNPCVYTPSTFPTTIY
DVQSGKVVAPDGVVYSVEASTHAGADGWKVMLAPTG*

Genomic Sequence

>Rv0594
ATGCTGACTCGCGCTATCAAGACCCAGCTGGTGTTGTTGACGGTGTTGGCGGTCATCGCG
GTGGTGGTCCTTGGTTGGTATTTCCTGCGGATACCCAGCCTGGTCGGCATCGGTCGATAC
ACGCTTTATGCCGAATTGCCTCGGTCCGGGGGTCTATACCGAACAGCCAACGTCACATAT
CGGGGCATCACCATAGGGAAGGTCACCGGCGTCGAACCAACCGAGCGGGGCGCGCGAGCA
ACCATGAGCATCGACAATGGCTACCAGATCCCCACCGACGCCTCGGCCAATGTGCACTCA
GTGTCGGCGGTCGGCGAGCAGTTCGTTGACCTGGTGTCGACCCGCACCAGCGGTCCGTAT
CTGCGGCATGGGCAGACGATCACCACGACTACGGTCCCCAGCCAGATTGGCCCGGCGCTG
GACGCCGCCAACCGTGGATTGGCAGTGCTGCCCAAAGACCGGGTCGCGTCGGTGCTGCAC
GAGGCGTCGGAGGCCGTGGGCGGGCTGGGATCCTCACTGAATCGCCTCATCGAAGCCACC
CAGGCAATCGCCCACGATGTCAGGGGCAGCCTCGAGGACATCGACGACATCATCGAGCGT
TCGGCGCCTATCATCGATAGCCAGGTCAATTCCGGCAACGAGATCGCCCGCTGGGCCGCC
AACCTCAACACGCTGGCCGCTCAGACCGCGCAGACCGATCCGGCGGTGCGAAGCATTCTG
GCCAACGCGGCACCGACTGCCGATCAGGTCAACGCCACGTTCAGCGACGTGCGGGAGTCG
TTGCCGCAGACGCTGGCCAATCTCGAGGTCGTAATCGATATGCTCAAGCGCTACCACAAC
GGCGTCGAGCAGGCGTTGGTGTTCTTGCCGCAGTCCGGCGCGATCGCCCAGTCGGTTACT
ACAGAGTTCCCCGGCCAGGCCGGACTGGGTGTCGGCGGCCTGGCGCTCAACCAACCACCG
CCGTGCCTGACCGGCTTCCTGCCGGCGTCGGAGTGGCGGTCACCTGCTGACACCAGCACC
GCACCGCTACCCAAGGGCACCTACTGCAGGATTCCGATGGACGCGAGCAATGTGGTTCGT
GGAGCACGCAACAACCCGTGTGTAGACGTGCCCGGCAAGCGGGCGGCGACCCCGCGGGAA
TGCCGCAGCAATGAAGCTTATGTGCCCGGGGGCACCAATCCCTGGTATGGGGACCCCAAC
CAGATGCTCAGCTGTCCCGCGCCGGCCGCGCGTTGTGACCAGCCGGTGAAGCCAGGCCAG
GTGATCCCGGCGCCGTCAGTTAACAATGGCATCAACCCGCTGCCCGCCGATCAGCTGCCA
GGCACACCTCCACCGGTCAACGATCCTTTGCAGCGACCTGGGTCAGGCACCGTCCAGTGC
AATGGGCAACAACCCAACCCGTGCGTCTACACCCCGAGCACATTTCCTACAACCATTTAC
GACGTGCAGAGCGGCAAAGTCGTAGCACCCGACGGTGTGGTGTATTCCGTTGAGGCTTCG
ACTCATGCCGGAGCCGACGGATGGAAGGTGATGCTGGCACCAACCGGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0591	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0591	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0591	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0593	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,M. Alonso-Hearn,TM. Eckstein,S. Sommer,LE. Bermudez A Mycobacterium avium subsp. paratuberculosis LuxR regulates cell envelope and virulence. Innate Immun 2010
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0592	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0591	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0591	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0591	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0590A	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0590	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) AK. Das, D. Mitra et al. Predicted molecular structure of the mammalian cell entry protein Mce1A of Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 2003
Interaction	Operon Rv0589	active	kholia.trupti	2012-10-05
	Co-expression (Functional linkage) D. Mitra, B. Saha et al. Correlating sequential homology of Mce1A, Mce2A, Mce3A and Mce4A with their possible functions in mammalian cell entry of Mycobacterium tuberculosis performing homology modeling. Tuberculosis (Edinburgh, Scotland) null
Interaction	Regulatory Rv0586	active	sourish10	2012-10-05
	Physical Interaction MD. Santangelo, F. Blanco et al. Mce2R from Mycobacterium tuberculosis represses the expression of the mce2 operon repressor from M. tuberculosis. Tuberculosis (Edinburgh, Scotland) 2008
Interaction	Regulatory Rv0586	active	sourish10	2012-10-05
	Physical Interaction authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Regulatory Rv0586	active	ahal4789	2012-10-05
	Physical Interaction MD. Santangelo, F. Blanco et al. Mce2R from Mycobacterium tuberculosis represses the expression of the mce2 operon repressor from M. tuberculosis. Tuberculosis (Edinburgh, Scotland) 2008
Interaction	Regulatory Rv0586	active	ahal4789	2012-10-05
	Physical Interaction authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	RegulatedBy Rv0586	active	yamir.moreno	2012-10-05
	LacZ-promoter fusion. expression levels of LacZ- regulated promoter fusion measured and compared between wild-type and trans-element mutation (knockout, over expression etc.). MD. Santangelo, F. Blanco et al. Mce2R from Mycobacterium tuberculosis represses the expression of the mce2 operon repressor from M. tuberculosis. Tuberculosis (Edinburgh, Scotland) 2008