Rv0843 - dehydrogenase

Expression: Most Significant Conditions for Rv0843

Protein Domains

Gene Information
Locus	Rv0843
Symbol
Gene Name	dehydrogenase
Location	939388 - 940392 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1005 bp Protein:335 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	29159
Related Genes	MAP0688 MAP1487c MAP1488c MAV_0873 MAV_2947 MAV_2948 Mkms_1108 Mkms_1109 Mmcs_1091 Mmcs_1092 MSMEG_2165 MSMEG_2166 MT0865 Mvan_1408 Mvan_1409 nfa32320 nfa32330 PPA2093 PPA2094
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0843
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0843 Transcript 1
MTRTSEGLAAFVVDQLEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAA
AALGEGDVIITTHRPHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADPRAGLPAA
IRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNEAADLAAVWQLPVVILVE
NIRGALSVHLDRYTHEPRVYRRAVAYGMPGVSVDGNDVEAVRDCVANAVVRARAGGGPTL
VQAITYRTTDFSGSDRGGYRDLAGSEQFLDPLIFARRRLIAAGTTRGRLDEQERAACQQV
ADAVAFAKARARPNGGGPISRPTSGWHQQPKTRF*

Genomic Sequence

>Rv0843
GTGACTCGTACCAGTGAAGGGTTGGCTGCGTTCGTGGTCGATCAGCTGGAGGAGCTGTAT
CGCCGGATGTGGGTGTTGCGACTGCTCGATATGGCGTTGGAGCAGTTGCGCATCGAAGGC
CTGATCAACGGGCCGCTGCAGGGTGGCTTCGGCCAGGAAGCAGTAAGTGTCGGTGCCGCG
GCGGCGCTGGGCGAAGGCGATGTCATCATCACCACCCATCGTCCGCATGCCCAACACGTT
GGTACTGACGCTCCGCTGGGCCCGGTGATCGCCGACATGCTGGGTGCGACCGCAGGCGAT
CTAGAAGGCGCTGACGAGGATGCGCACATTGCCGATCCTCGGGCCGGGCTACCGGCTGCA
ATACGCGTGGTCAAGCAATCGCCGCTGTTGGCTATCGGACACGCCTACGCCCTGTGGCTG
CGCGACACCGGACGGGTCACACTCTGCGTGACCCAAGACTGTGATGTTGATGCCGATGCC
TTCAACGAGGCCGCGGACCTAGCGGCCGTGTGGCAACTTCCGGTGGTGATTCTCGTCGAA
AACATTCGTGGTGCCCTAAGTGTGCACCTGGACAGGTACACGCACGAGCCTCGGGTTTAT
CGCCGGGCTGTGGCCTACGGAATGCCGGGGGTATCGGTGGACGGCAACGACGTCGAAGCG
GTCCGTGACTGTGTGGCCAACGCGGTGGTTCGGGCTCGCGCTGGTGGCGGCCCCACGCTG
GTCCAAGCCATCACCTACCGCACCACCGATTTCTCTGGATCTGACCGCGGCGGCTATCGC
GACCTGGCCGGATCCGAGCAGTTTCTGGATCCGCTGATCTTCGCGAGAAGGCGGCTGATT
GCTGCTGGCACGACCCGCGGTCGGCTCGACGAGCAGGAGCGGGCGGCATGCCAACAGGTG
GCCGATGCCGTGGCGTTCGCCAAGGCCAGGGCGCGGCCCAACGGCGGTGGGCCAATCAGC
CGACCAACATCCGGCTGGCACCAACAACCAAAGACCCGGTTCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:PDH pyruvate dehydrogenase - ISS	active	njamshidi	2012-10-05
	previous annotations with sequence based annotations of pdhA, pdhB, pdhC (Rv2497c, Rv2496c,Rv2495c) were found to be incorrect and removed - this is the appropriate annotation for PDH according to PMID: 16045627. J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Term	TBRXN:PDH pyruvate dehydrogenase - IDA	active	njamshidi	2012-10-05
	previous annotations with sequence based annotations of pdhA, pdhB, pdhC (Rv2497c, Rv2496c,Rv2495c) were found to be incorrect and removed - this is the appropriate annotation for PDH according to PMID: 16045627. J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006