Rv1189 - alternative RNA polymerase sigma factor sigI

Expression: Most Significant Conditions for Rv1189

Protein Domains

Gene Information
Locus	Rv1189
Symbol	sigI
Gene Name	alternative RNA polymerase sigma factor sigI
Location	1332092 - 1332964 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:873 bp Protein:291 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	30499
Related Genes	MAP2573 MAP2581c MAV_1342 MAV_1348 Mkms_2750 Mkms_4083 Mmcs_2706 Mmcs_4009 MSMEG_3508 MSMEG_5088 MT1226 MT1228 MT1241 MT1242 MUL_0955 Mvan_2997 Mvan_4512 Rv1191 Rv1203c Rv1204c
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1189
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1189 Transcript 1
MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAEDMVQEAFSRLLRAPVGDIDDERGWLIV
VTSRLCLDHIKSASTRRERPQDIAAWHDGDASVSSVDPADRVTLDDEVRLALLIMLERLG
PAERVVFVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESRIAASVEPAQHRVVT
RAFIEACSNGDLDTLLEVLDPGVAGEIDARKGVVVVGADRVGPTILRHWSHPATVLVAQP
VCGQPAVLAFVNRALAGVLALSIEAGKITKIHVLVQPSTLDPLRAELGGG*

Genomic Sequence

>Rv1189
ATGTCGCAACACGACCCGGTAAGTGCGGCCTGGCGGGCGCATCGGGCCTACCTGGTGGAC
CTCGCGTTTCGTATGGTAGGTGACATCGGCGTGGCCGAAGACATGGTGCAAGAGGCATTT
TCCCGCTTGCTGCGGGCTCCGGTCGGCGACATCGACGACGAGCGTGGCTGGCTGATCGTG
GTCACCAGCCGGCTGTGCCTGGATCACATCAAGTCGGCGTCGACACGCCGGGAGCGCCCG
CAGGACATCGCCGCATGGCACGACGGTGACGCCAGCGTGTCATCGGTTGACCCGGCTGAC
CGGGTGACTCTCGACGACGAGGTCCGGCTGGCTTTGCTGATCATGCTCGAGCGCCTCGGC
CCCGCGGAGCGGGTGGTGTTCGTGCTGCACGAGATCTTTGGGCTGCCCTACCAGCAAATC
GCCACGACGATTGGCAGCCAGGCCTCCACATGCCGGCAGCTGGCTCATCGGGCCCGTCGC
AAGATCAACGAATCGCGCATTGCGGCCAGCGTGGAGCCAGCCCAGCATCGCGTCGTCACC
AGAGCTTTCATCGAAGCCTGCTCCAACGGAGACCTGGACACCCTGCTCGAGGTGCTGGAT
CCGGGTGTCGCCGGCGAGATCGACGCCCGCAAAGGCGTTGTCGTCGTGGGCGCGGATCGG
GTTGGCCCGACCATCCTGCGCCACTGGAGTCACCCCGCCACCGTCCTGGTAGCCCAGCCG
GTGTGCGGTCAACCGGCGGTGCTGGCCTTTGTCAACCGAGCGCTTGCCGGCGTGTTGGCC
CTGTCGATCGAGGCCGGCAAGATCACAAAAATCCATGTCTTAGTGCAGCCTTCAACATTG
GACCCGTTACGGGCCGAACTCGGCGGCGGTTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv3328c	active	dreamsbeyondinfinity	2012-10-05
	Co-expression (Functional linkage) R. Manganelli,E. Dubnau,S. Tyagi,FR. Kramer,I. Smith Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis. Mol. Microbiol. 1999
Interaction	Regulatory Rv3328c	active	dreamsbeyondinfinity	2012-10-05
	Co-expression (Functional linkage) A. Waagmeester, J. Thompson et al. Identifying sigma factors in Mycobacterium smegmatis by comparative genomic analysis. Trends Microbiol. 2005
Interaction	Regulatory Rv3328c	active	dreamsbeyondinfinity	2012-10-05
	Co-expression (Functional linkage) J. Pendzich, W. Maksymowicz-Mazur et al. [Quantitative analysis of sigma genes expression in Mycobacterium tuberculosis cultures exposed to rifampicin and isoniazid] Wiad. Lek. 2004
Interaction	Regulatory Rv3328c	active	dreamsbeyondinfinity	2012-10-05
	Co-expression (Functional linkage) D. Homerova, L. Halgasova et al. Cascade of extracytoplasmic function sigma factors in Mycobacterium tuberculosis: identification of a sigmaJ-dependent promoter upstream of sigI. FEMS Microbiol. Lett. 2008