Rv1286 - bifunctional sulfate adenyltransferase/adenylylsulfate kinase cysN/cysC

Expression: Most Significant Conditions for Rv1286

Protein Domains

Gene Information
Locus	Rv1286
Symbol	cysN
Gene Name	bifunctional sulfate adenyltransferase/adenylylsulfate kinase cysN/cysC
Location	1438907 - 1440751 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1845 bp Protein:615 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33747
Related Genes	MAP2484c MAV_1437 Mkms_3992 ML1877 Mmcs_3918 MSMEG_4978 MT1324 MUL_3995 Mvan_4422
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1286
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1286 Transcript 1
MTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWASVEQTSKDRGHDYTDLALVTDGL
RAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLL
EQSRRHAFLASLLGIRHLVLAVNKMDLLGWDQEKFDAIRDEFHAFAARLDVQDVTSIPIS
ALHGDNVVTKSDQTPWYEGPSLLSHLEDVYIAGDRNMVDVRFPVQYVIRPHTLEHQDHRS
YAGTVASGVMRSGDEVVVLPIGKTTRITAIDGPNGPVAEAFPPMAVSVRLADDIDISRGD
MIARTHNQPRITQEFDATVCWMADNAVLEPGRDYVVKHTTRTVRARIAGLDYRLDVNTLH
RDKTATALKLNELGRVSLRTQVPLLLDEYTRNASTGSFILIDPDTNGTVAAGMVLRDVSA
RTPSPNTVRHRSLVTAQDRPPRGKTVWFTGLSGSGKSSVAMLVERKLLEKGISAYVLDGD
NLRHGLNADLGFSMADRAENLRRLSHVATLLADCGHLVLVPAISPLAEHRALARKVHADA
GIDFFEVFCDTPLQDCERRDPKGLYAKARAGEITHFTGIDSPYQRPKNPDLRLTPDRSID
EQAQEVIDLLESSS*

Genomic Sequence

>Rv1286
ATGACGACGCTATTGCGGCTGGCGACAGCGGGTTCCGTCGACGATGGCAAGTCCACGCTG
ATTGGGCGGCTACTCTACGACTCCAAGGCTGTGATGGAAGACCAGTGGGCGTCGGTGGAG
CAAACGTCCAAGGACCGGGGCCACGACTACACCGACCTGGCTCTGGTCACCGACGGCCTG
CGGGCCGAGCGGGAACAGGGCATCACCATCGACGTTGCCTACCGCTACTTCGCCACTCCC
AAGCGGAAATTCATCATTGCCGACACCCCGGGACACATCCAATACACCCGCAACATGGTG
ACCGGTGCGTCCACCGCCCAACTGGTGATCGTACTGGTGGATGCCCGGCACGGCTTGCTG
GAGCAATCCCGCCGGCACGCCTTCCTGGCGTCGCTGCTGGGCATCCGCCACCTGGTGCTC
GCGGTCAACAAGATGGACTTGCTTGGCTGGGACCAAGAGAAATTCGACGCGATTCGAGAC
GAATTCCACGCCTTCGCGGCCCGCCTCGACGTGCAGGACGTCACCTCCATCCCAATCTCC
GCGCTGCACGGCGACAACGTGGTGACCAAATCCGACCAGACGCCCTGGTACGAGGGACCG
TCGCTGCTGTCGCATCTCGAAGACGTCTACATCGCCGGTGACCGCAACATGGTCGACGTG
CGATTCCCGGTCCAGTACGTCATCCGGCCGCACACCCTCGAGCATCAAGACCACCGCAGC
TACGCGGGCACCGTGGCCAGTGGGGTAATGCGTTCAGGCGACGAAGTTGTCGTGCTGCCG
ATCGGTAAGACCACCCGGATCACCGCGATCGACGGCCCGAACGGCCCGGTGGCAGAAGCG
TTTCCGCCGATGGCGGTTTCGGTGCGGCTCGCCGACGACATCGATATCTCGCGTGGTGAC
ATGATCGCTCGCACCCACAACCAGCCCAGGATCACACAAGAATTCGACGCGACCGTGTGC
TGGATGGCCGACAACGCGGTGCTAGAGCCCGGCCGCGACTACGTTGTCAAGCACACCACC
CGAACCGTCCGCGCGAGGATAGCCGGGCTGGATTACCGGCTCGATGTCAACACCCTGCAT
CGCGACAAGACCGCAACGGCGTTGAAACTCAACGAACTGGGCCGTGTTTCGCTGCGCACC
CAGGTGCCGTTGCTGCTTGACGAGTACACCCGCAACGCTAGCACCGGCTCGTTCATCCTC
ATTGACCCCGACACCAACGGAACGGTGGCGGCGGGCATGGTGTTACGCGACGTCTCGGCC
CGCACGCCTAGCCCGAACACGGTGCGGCACAGATCGCTCGTCACTGCGCAAGATCGGCCG
CCCAGGGGCAAGACGGTGTGGTTTACCGGACTGTCCGGCTCCGGCAAGTCGTCGGTGGCC
ATGCTGGTTGAGCGGAAGCTACTCGAAAAGGGCATCTCCGCTTACGTTCTGGACGGCGAC
AACCTACGGCATGGCCTCAACGCCGACCTGGGCTTTTCCATGGCCGACCGCGCGGAGAAC
CTGCGCCGGCTGTCGCATGTGGCCACACTGCTCGCCGATTGTGGCCACCTGGTGCTGGTG
CCCGCGATCAGCCCCCTTGCTGAGCACCGTGCCCTGGCTCGTAAAGTGCACGCTGATGCG
GGAATCGACTTTTTCGAGGTGTTCTGTGACACCCCGCTGCAGGACTGTGAGAGGCGTGAT
CCCAAAGGGTTGTACGCCAAAGCGCGTGCGGGTGAGATCACGCACTTCACCGGGATCGAC
AGCCCATATCAGCGGCCCAAGAACCCAGACCTACGGCTTACGCCGGATCGCAGCATAGAC
GAGCAGGCGCAGGAGGTTATCGACCTGTTGGAGTCATCGTCTTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv1285	active	priti.priety	2012-10-05
	Co-expression Analysis R. Pinto, QX. Tang et al. The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex. Microbiology (Reading, Engl.) 2004
Interaction	PhysicalInteraction Rv1285	active	priti.priety	2012-10-05
	Co-expression Analysis authors,DP. Bhave,WB. Muse,KS. Carroll Drug targets in mycobacterial sulfur metabolism. Infect Disord Drug Targets 2007
Term	EC:2.7.1.25 Adenylyl-sulfate kinase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay R. Pinto, QX. Tang et al. The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex. Microbiology (Reading, Engl.) 2004