Rv1638 - excinuclease ABC subunit A uvrA

Expression: Most Significant Conditions for Rv1638

Protein Domains

Gene Information
Locus	Rv1638
Symbol	uvrA
Gene Name	excinuclease ABC subunit A uvrA
Location	1843741 - 1846659 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2919 bp Protein:973 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	602
Related Genes	Acel_1109 BL0702 CE1507 cg1560 DIP1159 jk0832 MAP1341 MAV_3135 Mkms_3032 ML1392 Mmcs_2988 MSMEG_3808 MT1675 MUL_1622 Mvan_3339 nfa19110 PPA0807 SAV6286
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1638
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1638 Transcript 1
MADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSA
YARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITEVYDYLRLLYARAGTPH
CPTCGERVARQTPQQIVDQVLAMPEGTRFLVLAPVVRTRKGEFADLFDKLNAQGYSRVRV
DGVVHPLTDPPKLKKQEKHDIEVVVDRLTVKAAAKRRLTDSVETALNLADGIVVLEFVDH
ELGAPHREQRFSEKLACPNGHALAVDDLEPRSFSFNSPYGACPECSGLGIRKEVDPELVV
PDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEALGFDVDTPWRKLPAKARKAILEGADE
QVHVRYRNRYGRTRSYYADFEGVLAFLQRKMSQTESEQMKERYEGFMRDVPCPVCAGTRL
KPEILAVTLAGESKGEHGAKSIAEVCELSIADCADFLNALTLGPREQAIAGQVLKEIRSR
LGFLLDVGLEYLSLSRAAATLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRR
LIETLTRLRDLGNTLIVVEHDEDTIEHADWIVDIGPGAGEHGGRIVHSGPYDELLRNKDS
ITGAYLSGRESIEIPAIRRSVDPRRQLTVVGAREHNLRGIDVSFPLGVLTSVTGVSGSGK
STLVNDILAAVLANRLNGARQVPGRHTRVTGLDYLDKLVRVDQSPIGRTPRSNPATYTGV
FDKIRTLFAATTEAKVRGYQPGRFSFNVKGGRCEACTGDGTIKIEMNFLPDVYVPCEVCQ
GARYNRETLEVHYKGKTVSEVLDMSIEEAAEFFEPIAGVHRYLRTLVDVGLGYVRLGQPA
PTLSGGEAQRVKLASELQKRSTGRTVYILDEPTTGLHFDDIRKLLNVINGLVDKGNTVIV
IEHNLDVIKTSDWIIDLGPEGGAGGGTVVAQGTPEDVAAVPASYTGKFLAEVVGGGASAA
TSRSNRRRNVSA*

Genomic Sequence

>Rv1638
GTGGCTGACCGCCTGATCGTCAAGGGTGCGCGCGAACACAATCTGCGCAGCGTCGACCTC
GACCTGCCCCGCGACGCGCTGATCGTCTTCACCGGGTTATCCGGATCGGGCAAGTCCTCG
CTCGCGTTCGACACCATCTTCGCCGAGGGGCAGCGGCGTTACGTGGAGTCGCTGTCGGCC
TACGCCCGCCAATTTCTCGGGCAGATGGACAAGCCGGACGTCGACTTCATCGAGGGGCTG
TCTCCGGCGGTGTCCATCGACCAGAAGTCGACCAACCGCAACCCACGATCGACGGTCGGG
ACCATCACCGAGGTGTACGACTACCTGCGGCTGTTGTATGCGCGCGCGGGCACGCCGCAC
TGCCCGACCTGCGGGGAGCGAGTCGCGCGCCAAACCCCGCAACAAATCGTCGATCAGGTG
CTGGCCATGCCGGAGGGCACTCGGTTTCTGGTGCTGGCCCCGGTGGTGCGTACCCGCAAG
GGCGAGTTCGCCGATCTGTTCGATAAGCTCAACGCCCAGGGCTACAGCCGGGTGCGGGTC
GACGGTGTGGTGCATCCGCTGACCGATCCGCCGAAGCTGAAAAAGCAGGAAAAGCACGAC
ATCGAGGTGGTGGTGGACCGTCTCACCGTCAAGGCCGCCGCCAAGCGGCGGCTCACCGAT
TCGGTGGAAACCGCGCTGAATTTGGCCGACGGGATCGTGGTGCTCGAATTCGTCGATCAT
GAACTGGGTGCACCGCATCGCGAGCAGCGGTTCTCCGAGAAGCTGGCCTGCCCCAACGGG
CACGCGCTGGCCGTCGACGACCTGGAGCCGCGGTCGTTCTCGTTCAACTCGCCCTACGGC
GCCTGCCCCGAATGCAGTGGTCTGGGCATCCGCAAGGAGGTCGACCCGGAGCTGGTGGTG
CCCGATCCGGATCGCACCCTGGCGCAGGGTGCGGTGGCGCCGTGGTCGAACGGCCACACC
GCGGAGTACTTCACCCGGATGATGGCCGGCCTTGGCGAGGCGCTCGGGTTCGACGTCGAC
ACGCCCTGGCGCAAGCTGCCGGCCAAGGCCCGCAAGGCGATTCTGGAAGGCGCCGACGAG
CAGGTGCACGTGCGCTACCGCAACCGCTACGGACGCACCCGGTCGTATTACGCCGATTTC
GAGGGTGTGCTGGCGTTCCTGCAACGCAAGATGTCCCAAACCGAGTCCGAGCAGATGAAG
GAGCGCTACGAGGGTTTCATGCGGGACGTGCCCTGCCCGGTGTGTGCGGGCACCCGGCTC
AAGCCCGAGATTCTGGCGGTGACGCTGGCTGGGGAGTCCAAGGGGGAGCACGGCGCCAAG
TCCATCGCCGAGGTGTGTGAGCTGTCGATCGCCGACTGCGCGGACTTCCTGAACGCGCTC
ACGCTGGGTCCGCGCGAGCAAGCGATCGCCGGGCAGGTGCTCAAGGAGATCCGGTCGCGG
CTCGGGTTTCTGCTCGACGTCGGGCTGGAGTACCTGTCGCTGTCCCGGGCGGCGGCCACG
CTGTCCGGCGGTGAGGCACAACGTATCCGGCTGGCCACCCAGATCGGCTCCGGCCTGGTG
GGTGTGCTCTACGTGCTCGACGAGCCGTCCATCGGGCTGCACCAGCGCGACAACCGTCGT
CTTATCGAAACCCTCACCCGGTTACGGGATTTGGGGAACACTTTGATCGTCGTCGAGCAC
GACGAGGACACCATCGAGCATGCGGACTGGATCGTCGACATCGGCCCGGGGGCCGGTGAG
CACGGTGGCCGCATCGTGCACAGCGGGCCCTACGATGAACTGCTACGCAACAAGGATTCG
ATCACCGGCGCCTACCTGTCCGGCCGGGAAAGCATTGAGATACCGGCGATTCGGCGTTCC
GTCGACCCCCGTCGTCAACTCACCGTCGTCGGCGCCCGCGAGCACAACTTGCGCGGGATC
GATGTGTCTTTCCCGCTGGGTGTGCTGACCTCGGTGACCGGTGTCTCGGGTTCGGGCAAG
TCGACGTTGGTCAACGACATCCTGGCCGCGGTGCTGGCCAACCGCCTCAACGGCGCCCGG
CAGGTCCCCGGCCGGCACACCCGGGTCACCGGGCTGGACTATCTGGACAAGCTGGTGCGG
GTGGACCAATCGCCGATCGGGCGCACACCGCGATCCAACCCGGCCACCTACACCGGTGTG
TTCGACAAGATCCGCACCCTGTTCGCCGCCACCACCGAGGCCAAGGTCCGCGGCTATCAA
CCCGGACGATTCTCGTTCAACGTCAAGGGCGGTCGCTGCGAGGCCTGCACCGGCGACGGC
ACCATCAAGATCGAGATGAACTTCCTGCCCGACGTGTACGTGCCGTGCGAGGTCTGCCAG
GGGGCCCGGTACAACCGCGAAACCCTCGAGGTGCACTACAAGGGCAAGACCGTCTCGGAA
GTGCTGGACATGTCCATCGAGGAAGCGGCGGAGTTCTTCGAGCCGATCGCCGGCGTCCAT
CGCTATCTACGCACCCTGGTCGACGTGGGCCTGGGCTACGTGCGGCTCGGCCAGCCCGCG
CCCACGCTGTCCGGCGGTGAGGCCCAGCGGGTCAAGCTGGCCTCGGAGCTGCAGAAGCGC
TCCACCGGGCGCACCGTCTACATCCTCGACGAGCCGACGACGGGACTGCACTTCGACGAC
ATACGCAAGCTGCTCAACGTGATCAACGGCCTGGTCGACAAGGGCAATACGGTGATCGTC
ATCGAACATAACCTGGACGTGATCAAGACATCGGATTGGATCATCGACCTGGGCCCGGAG
GGCGGTGCCGGCGGCGGAACCGTTGTCGCCCAAGGCACTCCGGAGGACGTTGCCGCGGTG
CCGGCGAGCTACACCGGGAAGTTTCTCGCTGAGGTCGTCGGCGGCGGTGCCTCGGCCGCC
ACATCGCGGTCGAACAGACGGCGCAACGTCAGCGCCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv2840c	active	akvsangli	2012-10-05
	authors,L. Cabusora,E. Sutton,A. Fulmer,CV. Forst Differential network expression during drug and stress response. Bioinformatics 2005
Interaction	Activation Rv1633	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometric Analysis P. Singh, KN. Patil et al. Mycobacterium tuberculosis UvrD1 and UvrA Proteins Suppress DNA Strand Exchange Promoted by Cognate and Non-cognate RecA Proteins. Biochemistry 2010
Interaction	Activation Rv1633	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometric Analysis K. Kurthkoti, P. Kumar et al. Important role of the nucleotide excision repair pathway in Mycobacterium smegmatis in conferring protection against commonly encountered DNA-damaging agents. Microbiology (Reading, Engl.) 2008
Interaction	Activation Rv1633	active	priyadarshinipriyanka2001	2012-10-05
	Spectrophotometric Analysis K. Kurthkoti, P. Kumar et al. Important role of the nucleotide excision repair pathway in Mycobacterium smegmatis in conferring protection against commonly encountered DNA-damaging agents. Microbiology (Reading, Engl.) 2008
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Other	TBPWY:NER and related	active	vmizrahi	2012-03-05
	Experimental evidence for a physical interaction RecA and UvrA
Other	TBPWY:NER and related	active	vmizrahi	2012-03-05
	Small molecule inhibitor of UvrABC complex identified
Other	TBPWY:NER and related	active	vmizrahi	2012-03-05
	Biochemically and structurally characterized recombinant M. tuberculosis UvrA. Structural investigation reveals an unprecedented conformation of the UvrB-binding domain proposed to be of functional relevance.