Rv2108 - PPE family protein

Expression: Most Significant Conditions for Rv2108

Protein Domains

Gene Information
Locus	Rv2108
Symbol	PPE36
Gene Name	PPE family protein
Location	2367711 - 2368442 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:732 bp Protein:244 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	13640
Related Genes	MAP2600 MAP2601 MAV_1322 MAV_1324 ML0411 MT2167
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2108
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2108 Transcript 1
MPNFWALPPEINSTRIYLGPGSGPILAAAQGWNALASELEKTKVGLQSALDTLLESYRGQ
SSQALIQQTLPYVQWLTTTAEHAHKTAIQLTAAANAYEQARAAMVPPAMVRANRVQTTVL
KAINWFGQFSTRIADKEADYEQMWFQDALVMENYWEAVQEAIQSTSHFEDPPEMADDYDE
AWMLNTVFDYHNENAKEEVIHLVPDVNKERGPIELVTKVDKEGTIRLVYDGEPTFSYKEH
PKF*

Genomic Sequence

>Rv2108
ATGCCCAATTTCTGGGCGTTGCCGCCCGAGATCAACTCCACCCGGATATATCTCGGCCCG
GGTTCTGGCCCGATACTGGCCGCCGCCCAGGGATGGAACGCTCTGGCCAGTGAGCTGGAA
AAGACGAAGGTGGGGTTGCAGTCAGCGCTCGACACGTTGCTGGAGTCGTATAGGGGTCAG
TCGTCGCAGGCTTTGATACAGCAGACCTTGCCGTATGTGCAGTGGCTGACCACGACCGCC
GAGCACGCCCATAAGACCGCGATCCAGCTCACGGCAGCGGCGAACGCCTACGAGCAGGCT
AGAGCGGCGATGGTGCCGCCGGCGATGGTGCGCGCGAACCGCGTGCAGACCACAGTGTTG
AAGGCAATCAACTGGTTCGGGCAATTCTCCACCAGGATCGCCGACAAGGAGGCCGACTAC
GAACAGATGTGGTTCCAAGACGCGCTAGTGATGGAGAACTATTGGGAAGCCGTGCAAGAG
GCGATACAGTCGACGTCGCATTTTGAGGATCCACCGGAGATGGCCGACGACTACGACGAG
GCCTGGATGCTCAACACCGTGTTCGACTATCACAACGAGAACGCAAAAGAGGAGGTCATC
CATCTCGTGCCCGACGTGAACAAGGAGAGGGGGCCCATCGAACTCGTAACCAAGGTAGAC
AAAGAGGGGACCATCAGACTCGTCTACGATGGGGAGCCCACGTTTTCATACAAGGAACAT
CCTAAGTTTTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv2107	active	kholia.trupti	2012-10-05
	Neighbourhood (Functional linkage) authors,M. Strong,MR. Sawaya,S. Wang,M. Phillips,D. Cascio,D. Eisenberg Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006
Interaction	PhysicalInteraction Rv2107	active	kholia.trupti	2012-10-05
	Neighbourhood (Functional linkage) S. Tundup, Y. Akhter et al. Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: evidence that PE Rv2431c is co-transcribed with PPE Rv2430c and their gene products interact with each other. FEBS Lett. 2006
Interaction	PhysicalInteraction Rv2107	active	kholia.trupti	2012-10-05
	Neighbourhood (Functional linkage) authors,M. Strong,MR. Sawaya,S. Wang,M. Phillips,D. Cascio,D. Eisenberg Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006
Interaction	PhysicalInteraction Rv2107	active	kholia.trupti	2012-10-05
	Neighbourhood (Functional linkage) S. Tundup, Y. Akhter et al. Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: evidence that PE Rv2431c is co-transcribed with PPE Rv2430c and their gene products interact with each other. FEBS Lett. 2006
Symbol	PPE36, p27	active	jlew	2012-03-07
	Mouse immune response to p27 V. Le Moigne, G. Robreau et al. Flagellin as a good carrier and potent adjuvant for Th1 response: study of mice immune response to the p27 (Rv2108) Mycobacterium tuberculosis antigen. Mol. Immunol. 2008
Symbol	p27	active	jlew	2012-03-07
	Western blot and immunoelectron microscopic analysis of BCG strain indicated that the p27 protein is localized in the membrane of the cell. V. Le Moigne, G. Robreau et al. Expression, immunochemical characterization and localization of the Mycobacterium tuberculosis protein p27. Tuberculosis (Edinburgh, Scotland) 2005