Rv2380c - peptide synthetase mbtE

Expression: Most Significant Conditions for Rv2380c

Protein Domains

Gene Information
Locus	Rv2380c
Symbol	mbtE
Gene Name	peptide synthetase mbtE
Location	2662067 - 2667115 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:5049 bp Protein:1683 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	31581
Related Genes	MAP2172c MAP2173c MAV_2013 Mkms_3529 Mmcs_3466 MSMEG_4511 MT2448 MUL_3634 Mvan_3845 nfa7660
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2380c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2380c Transcript 1
MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT
VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL
LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM
ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL
VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA
FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL
PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER
DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW
LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV
LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF
KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI
TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET
VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR
RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA
IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML
PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA
DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT
RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI
LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL
STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA
LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA
VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND
LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ
DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD
WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG
DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER
LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD
GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ
WP*

Genomic Sequence

>Rv2380c
ATGTGGTTCGTGCAGATGGCCGACCCCAGCGGTGCGTTACTCAACATCTGTGTGTCCTAC
CGCATCACCGGTGACATCGATCTGGCCAGGTTGCGCGACGCAGTCAACGCCGTCGCCCGT
CGCCATCGGATACTGCGTACCACCTACCCTGTCGGCGACGACGGAGTCGCCCAGCCGACC
GTGCACGCGGATCTTCGCCCCGGCTGGACACAATACGACCTGACGGACCTGTCCCAACGC
GCCCAGCGGCTGCGCCTGGAGGTGTTGGCTCAGCGCGAATTCTGCGCTCCCTTCGAGCTT
TCCCGCGACGCGCCATTGCGAATCACGGTGGTGCGCACGGCTGCCGACGAACACGTGCTG
CTGTTGGTGGCCCACCACATCGCCTGGGATGATGGTTCGTGGCGGGTGTTCTTCACCGAT
CTCACCCAGGCGTACTCGCGAGCTGACCTAGGGGCCGATCTGGGGCCAGAACACCGTCCG
TCGGCCGCATCCGGACCCGACACTACCGAGGCCGACCTCAACTATTGGCGCGCGATCATG
GCCGATCCGCCAGAGCCGCTGGAACTTCCCGGCCCAGCCGGAACGTGTGTGCCGACCAGT
TGGCGTGCCGCGCGCGCCACGTTGCGGCTGCCCGCCGACACCGCTGCGCGGGTGGCCACG
ATGGCGAAGAACACCGGTTGCACTCCCTACATGGTGCTGCTGGCCGCGTTCGGTGCCCTG
GTGCATCGCTACACCCACAGTGACGACTTCCTCGTGGCGGCTCCGGTGCTCAACCGTGGC
GCCGGAACCGAAGATGCCATCGGCTATTTCGGCAACACGGTAGCGATGCGGCTGCGACCG
CAATCGGCGATGAGTTTCCGGGAGTTGCTGACCGCCACCCGCGACATCGCCAGCGGGGCG
TTCGCACACCAACGGATCAACCTCGACCGCGTGGTAAGGGAACTGAACCCCGATCGCCGG
CACGGTGCCGAGCGCATGACCCGGGTCAGCTTCGGTTTCCGGGAGCCCGACGGCGGCGGA
TTCAACCCGCCAGGCATCGAGTGCGAGCGCTACGACCTGCGCAGCAACATCACGCAGCTG
CCGTTGGGCTTCATGGTCGAATTCGACCGCGCGGGTGTGCTGGTCGAGGCCGAACACCTG
GTGGAGATCCTGGAACCCGCCCTGGCCAAGCAGATGCTTCGACACTTCGGTGTGCTGCTC
GACAATGCGCTGGCCGCCCCCGACAACACGTTGTCGGGGCTGGCGCTGATGGATGAGCGC
GACGCCGCCAGGCTGCGCGAGGTGTCGCGCGGCGAGCGGTTCGATACCCCTGTCAAAACC
CTCGTGGACCTGGTGAACGAGCAGACCACGCGGACTCCCGACGCCACCGCCGTGGTGTAT
GAGGGCCAACACTTCACCTACCACGACCTCAATGAGGCGTCGAACCGGTTGGGGCACTGG
CTGATCGAGCAGGGGATAGGCAGCGAAGACCGGGTCGCGGTACTTCTTGACAAATCGCCG
GACCTGATCGTCACGGCCTTGGGGGTGGTCAAGTCCGGGGCGGTGTATGTGCCCGTGGAT
CCCAGCTACCCGCAAGACCGGCTGGATTTCATCCTCGCCGACTGCGACGCGAAACTGGTG
CTGCGCACGCCAGTACGTGAGCTGGCCGGATACCGCAGCGACGACCCCACCGACGCCGAT
CGAATCCGGCCGCTACGGCCAGACAACACGGCCTATCTCATCTACACGTCCGGTACCACC
GGATTGCCCAAAGGTGTCGCGGTGCCACACCGCCCCGTCGCCGAGTACTTCGTCTGGTTC
AAGGGCGAATACGACGTCGACGACACCGACCGGCTACTGCAGGTCGCCTCACCCAGCTTC
GACGTCTCGATCGCCGAGATCTTCGGCACGCTGGCCTGTGGCGCGCGGATGGTGATACCA
CGCCCCGGGGGACTCACCGACATTGGATATCTCACCGCCCTGTTGCGCGACGAGGGCATC
ACGGCAATGCATTTCGTGCCGTCCCTACTCGGGCTGTTCCTGTCGCTGCCGGGTGTGAGC
CAGTGGCGGACGTTGCAGCGGGTACCCATCGGCGGGGAGCCGCTACCCGGTGAGGTGGCC
GACAAGTTCCACGCGACATTCGATGCGCTGCTGCACAACTTCTACGGTCCAACCGAAACC
GTGATCAACGCCAGCCGGTTTAAAGTGGTGGGCCCACAGGGCACCCGCATCGTGCCCATC
GGCCGGCCCAAGATCAACACCACCATGCACCTGCTCGACGATTCGTTGCAGCCGGTGCCG
ACCGGTGTGATCGGCGAGATCTATATTGGAGGGACGCATGTCGCATACGGATACCATCGC
CGCGCCGGGCTGACCGCGGAGCGATTCGTTGCCGACCCGTTTAATCCCGGTTCCCGCATG
TACCGGTCCGGGGATCTGGCGCGCCGCAATGCTGACGGTGACATCGAGTTCGTGGGCCGT
GCCGACGAGCAGGTCAAGATTCGCGGATTCCGAATCGAACTCGGTGACGTAGCAGCGGCC
ATCGCGGTCGACCCTACGGTCGGGCAGGCCGTTGTGGTGGTTAGCGACCTGCCGCGGCTG
GGCAAGAGTCTGGTGGGCTACGTGACACCCGCCGCGGGCGGCGACGGACCCGCCGATGTC
GGCGTCGATCTCGACCGCATCCGCGCCCGGGTGGCCGCGGCACTGCCTGAATATATGCTG
CCCGCGGCCTATGTTGTGCTGGATGAGATTCCGATCACCGCGCATGGCAAAATCGACCGC
GCCGCGCTGCCGGAACCGCAGATCGCGTCGGACACCGAGTTCCGCGCGCCGCAGACCGCC
ACCGAGCGGCGCCTTGCCCAACTGTTCGGTGAGCTGCTCGGCCGCGACCGAGTGGGTGCT
GACGACTCGTTCTTCGACCTCGGCGGTCACTCGCTGCTGGCAACCAAACTCGTTGCGGCC
GTGCGCAACGCGTTCGGCGTCGATGTCGGTGTGCGGGAGATCTTCGAATTCGCCACGGTG
ACCGCGTTGGCCGGACACATCGATACGTTGGATTCGGATTCGGCGAGGCCGCGGCTGACC
CGGGTGGATCATGACGGGCCAGTGCGATTGTCGTCGTCTCAAATGCGTAGCTGGTTCAAC
TATCGCTTCGACGGGCCCAACGCCGTCAACAACATTCCCTTCGCCGCGGCATTGCATGGG
CCCTGCGACACCAACGCGTTCGCGGCGGCCATCACCGATGTGGTGGCACGCCACGAGATC
CTGCGCACCGTCTACCGCGAGATCGGCGGCGTGCCACACCAGATCATCCAGCCGCCCGCC
GAGGTGCCGGTGCGGTGCGCCGCCGGGTCCGACGCCGCGTGGCTGCGAGCCGAACTGAAC
AACGAGCGAGGTTACGTTTTCGACCTGGAAACCGACTGGCCGATCCGGGCGGCGCTGCTG
AGCACGCCGGAGCAGACCGTGTTGTCGCTGGTGGTGCATCACATCGCCGGCGACCACTGG
TCGGCTGGGGTGTTGTTCACCGATCTGCTGACCGCATACCGGGCCCGCAGCACCGGACAA
CGGCCGTCGTGGGCACCGCTGCCGGTGCAGTACGCCGACTACAGCGTGTGGCAGTCGGCG
CTACTCGACGACGGTGCGGGCATCGTCGGTCCGCAACGCGACTACTGGATCCGCCAGCTG
GGGGGCCTGGCAGGCGAAACCGGTCTGCGCCCGGACTTCCCGCGCCCGGCCCTGCTCAGC
GGTGCCGGTGACGCGGTCGAATTTCGTCTCGGCGCCGCGATCCGCGACAAATTGGCTGCC
GTGAGCCGAGACCTCGGTGTCACCGAGTTCATGCTGCTACAGGCCGCCGTCGCGGTGGTG
TTACACAAGGCCGGCGGCGGGGTAGACGTCCCCATCGGCGCCCCGGTGGCCGGTCGCAGC
GAGGCCAACCTGGACCAGCTCATCGGGTTCTTCATCAACATCGTGGTGTTGCGCAACGAC
CTGCGCGGGAACCCCACGCTGCGCGAGGTGCTGCAGCGCACCAGGCAGATGGCGCTGGCA
GCGTATGCACATCAGGACCTGCCGTTCGACCAGGTGGTGGAGGCGGTCAACCCCCAGCGG
TCGCTGTCCCGCAATCCGTTGTTCGACATTGTTGTGCACGTTCGCGAACAAATGCCGCAA
GACCACGTCATCGACACCGGGCCCGACGGTGACACCACGTTGCGCGTGCTGGAGCCGACA
TTCGATGCCGCGCAAGCCGATCTATCGGTCAACTTCTTCGCCTGCGGCGACGAGTACCGC
GGCCACGTCATCTACCGCACCGAGTTGTATGAGCGCGCCACCGCACAACGCTTCGCCGAC
TGGCTAGTCCGTGTCGTCGAGGCGTTCGCCGACCGTCCGGACCAACCGCTGCGCGAGGTC
GAGATGGTCAGCGCGCAAGCCAGACGGCGCATTTTGGACCGGTCCAATGCGGGCGCCGGA
ACGGCCCGGGTGTACCTGCTTGACGACGCACTTAAGCCCGTTCCGGTAGGCGTGGTGGGT
GACGTTTATTACGGTGGCGGTCCCGCCGTCGGTGCCCGGTTGGCCCGGCCATCGGAGACC
GCGACCCGATTCGTTGCCGATCCGTTCGCCGCGCAACCGGGTTCTCGGCTCTACCGCAAC
GGCGAGCGCGGAGTGTGGAAGGCCGACGGCCAACTGGAGCTGCTGGCCGAAATCGAACGG
CTGCCAACGGCGCAGGCGGCACCGGTGCCGGCCGAGCCCGCCGACACCGAAACCGAGCGC
GCGCTGGCTGCCATCCTCGCCGACGTGCTCGAGGTGGGGGAGGTCGGACGCTACGACGAC
TTCTTCAACCTCGGCGGCGACAGCATCCTCGCGACTCAGGTGGCTGCCCGGGCTCGAGAT
GGCGGGATACCGCTGACCGCGCGGATGGTTTTCGAGCATCCCGTTTTGTGTGAGCTCGCC
GCCGCGGTCGACGCCAAGCCTCACGTCGAGGCCGAGCCGGACGACAAGCATCACGCGCCG
ATGAGCACATCAGGGCTTTCCCCAGACGAACTGTCGGCCCTGACCGCGTCATGGGACCAG
TGGCCGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:MCBTS3 carboxymycobactin synthesis - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	TBRXN:MCBTS3 carboxymycobactin synthesis - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,J. Gobin,CH. Moore,JR. Reeve,DK. Wong,BW. Gibson,MA. Horwitz Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc. Natl. Acad. Sci. U.S.A. 1995
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - IDA	active	njamshidi	2012-10-05
	For carboxymycobactin see PMID: 7761471, also Cole et al text: Tuberculosis and the Tubercle Bacillus - R group length varies from 2-9 carbons - cmcbtt has 8C tail w/ last carbon fully oxidized to carboxyl group. Will add methyl ester form for current version. See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,J. Gobin,CH. Moore,JR. Reeve,DK. Wong,BW. Gibson,MA. Horwitz Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc. Natl. Acad. Sci. U.S.A. 1995
Term	TBRXN:MCBTS2 mycobactin synthesis - IPI	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - IPI	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	TBRXN:MCBTS2 mycobactin synthesis - ISS	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Term	EC:6.2.1.13 Acetate--CoA ligase (ADP-forming). - ISS	active	njamshidi	2012-10-05
	See PMID: 14670352. Mycobactin T is commonly found in Mtb authors,C. Ratledge Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 2004
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) GM. Rodriguez & I. Smith Mechanisms of iron regulation in mycobacteria: role in physiology and virulence. Mol. Microbiol. 2003
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) LE. Quadri, J. Sello et al. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. Chem. Biol. 1998
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) authors,JJ. De Voss,K. Rutter,BG. Schroeder,CE. Barry Iron acquisition and metabolism by mycobacteria. J. Bacteriol. 1999
Interaction	Regulatory Rv2711	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) GM. Rodriguez, MI. Voskuil et al. ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 2002
Interaction	RegulatedBy Rv2711	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. GM. Rodriguez, MI. Voskuil et al. ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 2002
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,JJ. De Voss,K. Rutter,BG. Schroeder,CE. Barry Iron acquisition and metabolism by mycobacteria. J. Bacteriol. 1999