Rv2394 - gamma-glutamyltranspeptidase precursor ggtB

Expression: Most Significant Conditions for Rv2394

Protein Domains

Gene Information
Locus	Rv2394
Symbol	ggtB
Gene Name	gamma-glutamyltranspeptidase precursor ggtB
Location	2688010 - 2689941 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1932 bp Protein:644 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	24850
Related Genes	CE1029 cg1090 MAP0607c MAV_0717 Mkms_0889 Mkms_2441 Mmcs_0872 Mmcs_2394 MSMEG_1463 MSMEG_1615 MSMEG_3076 MT0797 MT2464 MUL_0486 Mvan_1330 nfa35970 Rv0773c SAV1957
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2394
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2394 Transcript 1
MSVWLRAGALVAAVMLSLSGCGGFHAGAPSTAGPCEIVPNGTPAPKTPPATVPSSRNLAT
NPEIATGYRRDMTVVRTAHYAAATANPLATQVACRVLRDGGTAADAVVAAQAVLGLVEPQ
SSGIGGGGYLVYFDARTGSVQAYDGREVAPAAATENYLRWVSDVDRSAPRPNARASGRSI
GVPGILRMLEMVHNEHGRTPWRDLFGPAVTLADGGFDISARMGAAISDAAPQLRDDPEAR
KYFLNPDGSPKPAGTRLTNPAYSKTLSAIASAGANAFYSGDIAHDIVAAASDTSNGRTPG
LLTIEDLAGYLAKRRQPLCTTYRGREICGMPSSGGVAVAATLGILEHFPMSDYAPSKVDL
NGGRPTVMGVHLIAEAERLAYADRDQYIADVDFVRLPGGSLTTLVDPGYLAARAALISPQ
HSMGSARPGDFGAPTAVAPPVPEHGTSHLSVVDSYGNAATLTTTVESSFGSYHLVDGFIL
NNQLSDFSAEPHATDGSPVANRVEPGKRPRSSMAPTLVFDHSSAGRGALYAVLGSPGGSM
IIQFVVKTLVAMLDWGLNPQQAVSLVDFGAANSPHTNLGGENPEINTSDDGDHDPLVQGL
RALGHRVNLAEQSSGLSAITRSEAGWAGGADPRREGAVMGDDA*

Genomic Sequence

>Rv2394
GTGAGTGTTTGGTTGCGAGCGGGCGCCTTGGTGGCTGCAGTGATGCTGTCGCTGAGCGGA
TGTGGCGGCTTCCACGCGGGTGCGCCAAGCACGGCCGGTCCGTGCGAGATCGTCCCCAAT
GGCACGCCGGCGCCCAAGACACCCCCGGCTACCGTGCCTTCGTCGCGCAACCTCGCGACC
AACCCCGAGATCGCCACCGGCTACCGCCGGGACATGACCGTGGTGCGGACCGCCCACTAT
GCGGCAGCCACCGCCAATCCGCTGGCCACTCAGGTGGCCTGCCGAGTATTGCGCGACGGT
GGTACCGCCGCCGATGCCGTCGTGGCCGCCCAGGCGGTGCTGGGGTTGGTCGAACCGCAA
TCCTCCGGGATCGGCGGCGGCGGATATCTGGTGTACTTCGACGCCCGCACGGGCTCAGTG
CAGGCCTACGACGGCCGTGAGGTGGCCCCAGCGGCCGCCACCGAGAACTACCTTCGCTGG
GTCAGCGACGTCGACCGCAGCGCGCCCAGGCCCAACGCCCGAGCCTCGGGACGGTCGATC
GGAGTACCGGGCATCCTGCGAATGCTGGAGATGGTGCACAACGAGCACGGGCGCACACCC
TGGCGCGACCTCTTCGGCCCCGCGGTAACGCTGGCCGATGGCGGTTTTGACATCAGCGCC
AGGATGGGCGCGGCCATCTCCGACGCTGCGCCGCAACTGCGAGACGACCCGGAGGCTCGC
AAGTATTTCCTCAATCCCGACGGCAGCCCGAAACCCGCGGGAACCCGGCTGACGAACCCC
GCGTACTCAAAAACCCTGTCCGCCATCGCCTCCGCCGGCGCCAACGCCTTCTATTCCGGC
GACATTGCCCACGACATCGTGGCGGCGGCGAGCGACACATCGAATGGCCGCACGCCGGGC
CTGTTGACCATTGAGGACCTGGCGGGTTACCTCGCCAAGAGACGCCAACCGTTGTGCACG
ACCTATCGCGGCCGGGAGATCTGCGGCATGCCATCGTCGGGTGGCGTCGCCGTGGCCGCA
ACCTTGGGCATCCTCGAGCACTTCCCGATGAGCGACTACGCGCCCAGCAAGGTCGACCTC
AACGGCGGTCGCCCGACCGTGATGGGGGTTCACCTGATAGCGGAGGCCGAACGGCTGGCC
TATGCCGACCGCGACCAATATATCGCTGACGTCGATTTTGTCCGGCTGCCCGGCGGCTCG
CTCACCACGCTGGTTGACCCGGGCTACTTGGCAGCACGCGCCGCGCTAATCTCGCCGCAA
CACAGCATGGGCAGCGCCAGACCGGGGGACTTCGGCGCACCGACGGCCGTCGCCCCGCCA
GTGCCTGAGCATGGCACCAGCCACCTCAGCGTCGTCGATTCGTACGGCAATGCGGCCACG
TTGACGACGACGGTGGAATCTTCGTTCGGCTCCTACCACCTGGTGGACGGATTCATCCTC
AACAACCAGCTGAGCGATTTCAGCGCCGAGCCACACGCTACTGACGGATCACCGGTGGCT
AACCGGGTCGAGCCTGGGAAGCGACCGCGCAGTTCGATGGCACCGACGTTGGTGTTCGAT
CACTCGTCGGCGGGGCGCGGTGCGCTGTACGCGGTGCTCGGTTCTCCGGGCGGCTCCATG
ATCATCCAGTTCGTCGTGAAAACACTTGTGGCGATGCTGGATTGGGGTCTGAATCCGCAG
CAGGCGGTTTCCCTGGTCGATTTCGGCGCCGCGAACTCGCCGCACACTAACCTCGGCGGT
GAGAATCCCGAGATCAACACTTCCGACGATGGTGATCATGACCCGCTGGTGCAAGGCCTG
CGCGCGCTGGGGCATCGAGTTAATCTTGCCGAGCAATCCAGTGGGCTCTCGGCGATCACC
CGCAGCGAGGCGGGTTGGGCCGGCGGCGCCGACCCACGCCGCGAAGGCGCGGTCATGGGC
GACGATGCCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:GTMLT g-glutamyltransferase - IPI	active	njamshidi	2012-10-05
	see PMID: 16452418, 8095770 authors,MJ. Penninckx,MT. Elskens Metabolism and functions of glutathione in micro-organisms. Adv. Microb. Physiol. 1993
Term	EC:2.3.2.2 Gamma-glutamyltransferase. - IPI	active	njamshidi	2012-10-05
	see PMID: 16452418, 8095770 authors,MJ. Penninckx,MT. Elskens Metabolism and functions of glutathione in micro-organisms. Adv. Microb. Physiol. 1993
Term	TBRXN:GTMLT g-glutamyltransferase - IPI	active	njamshidi	2012-10-05
	see PMID: 16452418, 8095770 authors,YK. Dayaram,MT. Talaue,ND. Connell,V. Venketaraman Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione. J. Bacteriol. 2006
Term	EC:2.3.2.2 Gamma-glutamyltransferase. - IPI	active	njamshidi	2012-10-05
	see PMID: 16452418, 8095770 authors,YK. Dayaram,MT. Talaue,ND. Connell,V. Venketaraman Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione. J. Bacteriol. 2006
Term	TBRXN:GTMLT g-glutamyltransferase - ISS	active	njamshidi	2012-10-05
	see PMID: 16452418, 8095770 authors,MJ. Penninckx,MT. Elskens Metabolism and functions of glutathione in micro-organisms. Adv. Microb. Physiol. 1993
Term	EC:2.3.2.2 Gamma-glutamyltransferase. - ISS	active	njamshidi	2012-10-05
	see PMID: 16452418, 8095770 authors,MJ. Penninckx,MT. Elskens Metabolism and functions of glutathione in micro-organisms. Adv. Microb. Physiol. 1993
Term	TBRXN:GTMLT g-glutamyltransferase - ISS	active	njamshidi	2012-10-05
	see PMID: 16452418, 8095770 authors,YK. Dayaram,MT. Talaue,ND. Connell,V. Venketaraman Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione. J. Bacteriol. 2006
Term	EC:2.3.2.2 Gamma-glutamyltransferase. - ISS	active	njamshidi	2012-10-05
	see PMID: 16452418, 8095770 authors,YK. Dayaram,MT. Talaue,ND. Connell,V. Venketaraman Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione. J. Bacteriol. 2006
Interaction	RegulatedBy Rv0485	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique. RM. Goldstone, SD. Goonesekera et al. The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence. Infect. Immun. 2009
Interaction	RegulatedBy Rv0485	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. qRT-PCR. mRNA expression levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using qRT-PCR technique. RM. Goldstone, SD. Goonesekera et al. The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence. Infect. Immun. 2009