Rv2428 - alkyl hydroperoxide reductase C protein ahpC
Protein Domains

Gene Information
LocusRv2428
SymbolahpC
Gene Namealkyl hydroperoxide reductase C protein ahpC
Location2726193 - 2726780 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:588 bp
Protein:196 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number33644
Related GenesDIP1420 jk0155 MAP1589c MAV_2839 ML2042 MSMEG_4891 MT2503 MUL_2999 Mvan_1420 nfa37890 PPA1989 SAV3232
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionActivation Rv2429activesinghpankaj21162012-10-05
Structural analysis
BG. Guimarães, H. Souchon et al. Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. J. Biol. Chem. 2005
InteractionActivation Rv2429activesinghpankaj21162012-10-05
Structural analysis
BG. Guimarães, H. Souchon et al. Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. J. Biol. Chem. 2005
InteractionPhysicalInteraction Rv0462activesourish102012-10-05
Gene Neighbourhood (Functional Linkage)
R. Bryk, CD. Lima et al. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 2002
InteractionPhysicalInteraction Rv0462activesourish102012-10-05
Gene Neighbourhood (Functional Linkage)
A. Argyrou & JS. Blanchard Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. Biochemistry 2001
InteractionPhysicalInteraction Rv0462activeahal47892012-10-05
Gene Neighbourhood (Functional Linkage)
R. Bryk, CD. Lima et al. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 2002
InteractionPhysicalInteraction Rv0462activeahal47892012-10-05
Gene Neighbourhood (Functional Linkage)
A. Argyrou & JS. Blanchard Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. Biochemistry 2001
InteractionRegulatedBy Rv0981activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
InteractionRegulatedBy Rv0117activeyamir.moreno2012-10-05
E.coli orthology based inference. Orthologous pair regulator-target found in E.coli.
G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
InteractionRegulatedBy Rv2711activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
GM. Rodriguez, MI. Voskuil et al. ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 2002
InteractionRegulatedBy Rv0117activeyamir.moreno2012-10-05
E.coli orthology based inference. Orthologous pair regulator-target found in E.coli.
authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
InteractionRegulatedBy Rv0491activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003