Rv2697c - deoxyuridine 5-triphosphate nucleotidohydrolase dut

Expression: Most Significant Conditions for Rv2697c

Protein Domains

Gene Information
Locus	Rv2697c
Symbol	dut
Gene Name	deoxyuridine 5-triphosphate nucleotidohydrolase dut
Location	3013683 - 3014147 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:465 bp Protein:155 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	721
Related Genes	Acel_1402 BL1438 CE1799 cg2086 DIP1400 jk1082 MAP2814c MAV_3589 Mkms_2237 ML1028 Mmcs_2191 MSMEG_2765 MT2771 MUL_3335 Mvan_2467 nfa37530 PPA1054 SAV2399
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2697c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2697c Transcript 1
MSTTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRALVRTGVAVAVPFGMVGL
VHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAAPIVVHRGDRIAQLLVQRVE
LVELVEVSSFDEAGLASTSRGDGGHGSSGGHASL*

Genomic Sequence

>Rv2697c
GTGTCGACCACTCTGGCGATCGTCCGCCTCGACCCCGGGCTCCCGCTGCCCAGCCGCGCT
CACGACGGCGACGCCGGCGTTGATCTCTACAGCGCCGAAGACGTCGAGCTGGCACCTGGG
CGCCGCGCCCTGGTACGGACGGGTGTTGCGGTCGCCGTCCCGTTCGGCATGGTCGGGCTG
GTCCATCCGCGCTCCGGGTTGGCCACGCGGGTGGGGCTTTCGATCGTCAACAGTCCGGGC
ACCATCGACGCGGGTTATCGTGGGGAGATCAAGGTGGCCCTGATCAACTTGGACCCAGCC
GCGCCCATCGTGGTACATCGCGGTGACCGAATCGCCCAGTTGCTAGTGCAACGGGTTGAG
TTGGTCGAGCTGGTCGAGGTCTCGTCGTTCGACGAGGCCGGGCTGGCCTCGACATCCCGC
GGCGACGGTGGCCACGGTTCCTCCGGCGGACATGCGAGTTTGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Other	TBPWY:Nucleotide pool	active	vmizrahi	2012-03-05
	K(d) for alpha,beta-imido-dUTP binding to Mtb dUTPase is 10-fold less than for human dUTPase
Other	TBPWY:Nucleotide pool	active	vmizrahi	2012-03-05
	Crystal structure of the mycobacterial enzyme in complex with the isosteric substrate analog, alpha,beta-imido-dUTP and Mg(2+) at 1.5A resolution was determined that visualizes the full-length C-terminus. Interactions of a conserved motif important in catalysis, the Mycobacterium-specific five-residue-loop insert and C-terminal tetrapeptide described.
Term	EC:3.6.1.23 dUTP diphosphatase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay authors,S. Chan,B. Segelke,T. Lekin,H. Krupka,US. Cho,MY. Kim,M. So,CY. Kim,CM. Naranjo,YC. Rogers,MS. Park,GS. Waldo,I. Pashkov,D. Cascio,JL. Perry,MR. Sawaya Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. J. Mol. Biol. 2004