Rv2924c - formamidopyrimidine-DNA glycosylase fpg

Expression: Most Significant Conditions for Rv2924c

Protein Domains

Gene Information
Locus	Rv2924c
Symbol	fpg
Gene Name	formamidopyrimidine-DNA glycosylase fpg
Location	3238601 - 3239470 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:870 bp Protein:290 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	28540
Related Genes	Acel_1573 CE1975 cg2272 DIP1543 jk1205 MAP2994c MAV_3782 Mkms_1996 ML1658 Mmcs_1950 MSMEG_2419 MT2994 MUL_2031 Mvan_2172 nfa41830 PPA1451 SAV2664
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2924c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2924c Transcript 1
MPELPEVEVVRRGLQAHVTGRTITEVRVHHPRAVRRHDAGPADLTARLRGARINGTDRRG
KYLWLTLNTAGVHRPTDTALVVHLGMSGQMLLGAVPCAAHVRISALLDDGTVLSFADQRT
FGGWLLADLVTVDGSVVPVPVAHLARDPLDPRFDCDAVVKVLRRKHSELKRQLLDQRVVS
GIGNIYADEALWRAKVNGAHVAATLRCRRLGAVLHAAADVMREALAKGGTSFDSLYVNVN
GESGYFERSLDAYGREGENCRRCGAVIRRERFMNRSSFYCPRCQPRPRK*

Genomic Sequence

>Rv2924c
ATGCCCGAGCTGCCCGAAGTCGAGGTGGTGCGGCGCGGCTTGCAGGCTCACGTGACCGGC
CGGACCATCACCGAGGTTCGGGTGCACCACCCCCGCGCTGTGCGCCGCCACGATGCCGGG
CCCGCGGATCTGACGGCGCGGCTGCGGGGAGCGCGGATCAACGGAACCGATCGGCGCGGC
AAGTACCTGTGGTTGACACTCAATACGGCTGGGGTCCATAGGCCGACGGACACCGCACTC
GTGGTGCACCTGGGCATGAGTGGGCAGATGCTGCTCGGGGCGGTGCCGTGTGCCGCTCAC
GTCCGGATTTCCGCGCTGCTCGACGACGGGACCGTGCTGAGCTTCGCTGACCAACGGACC
TTCGGAGGGTGGCTGCTTGCCGACCTGGTGACGGTGGACGGCAGCGTGGTACCGGTGCCG
GTCGCCCACCTGGCGCGCGACCCGCTTGACCCGCGGTTCGATTGTGACGCTGTAGTTAAA
GTGTTGCGGCGCAAGCATTCCGAACTCAAGCGCCAGCTGCTGGATCAGCGGGTGGTGTCG
GGAATCGGCAACATCTATGCCGATGAGGCGCTGTGGCGGGCCAAGGTGAACGGCGCCCAC
GTCGCCGCCACACTAAGGTGCCGGCGTCTGGGAGCGGTCCTGCATGCCGCCGCCGACGTG
ATGCGCGAAGCGCTGGCGAAAGGTGGCACCTCGTTCGACTCTTTGTATGTCAACGTCAAC
GGCGAGTCGGGCTACTTCGAGCGGTCGCTGGACGCTTATGGCCGCGAAGGCGAAAACTGT
CGGCGCTGCGGCGCGGTGATACGCCGGGAGAGGTTTATGAACCGCTCGTCGTTCTACTGC
CCGCGATGCCAGCCGCGGCCCCGAAAGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Other	TBPWY:Base excision repair (BER)	active	vmizrahi	2012-03-05
	Fpg1 has substrate specificity similar to that of E. coli Fpg. Is more efficient at removing spiroiminodihydantoin (Sp) than 7,8-dihydro-8-oxoguanine (8-oxoG). However, Mtb Fpg1 shows a substantially increased opposite base discrimination compared to E. coli Fpg
Other	TBPWY:Base excision repair (BER)	active	vmizrahi	2012-03-05
	Over-expressed, purified and biochemically characterised. The enzyme removed faPy and 5-hydroxycytosine lesions, as well as 8-oxo-7,8-dihydroguanine (8oxoG) opposite to C, T and G. Mtb-Fpg1 thus exhibited substrate specificities typical for Fpg enzymes.
Symbol	fpg1	active	vmizrahi	2012-03-05
	Over-expressed, purified and biochemically characterised. The enzyme removed faPy and 5-hydroxycytosine lesions, as well as 8-oxo-7,8-dihydroguanine (8oxoG) opposite to C, T and G. Mtb-Fpg1 thus exhibited substrate specificities typical for Fpg enzymes.