Rv2952 - methyltransferase/methylase
Protein Domains

Gene Information
LocusRv2952
Symbol
Gene Namemethyltransferase/methylase
Location3304441 - 3305253 (+)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:813 bp
Protein:271 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number26431
Related GenesMAP3760c ML0130 MSMEG_0393 MT3026 MUL_2009 MUL_2377
Transcriptional Regulation
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Regulatory Network
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Expression Correlation Genes with Correlated Expression
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Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
NameSAM-dependent O-methyltransferase involved in the formation of (phenol)phthiocerol dimycocerosates from (phenol)phthiodiolone dimycocerosates. Catalyzes the transfer of a methyl group to the third hydroxyl group of (phenol)phthiotriol in phthiocerol dimycocerosates and glycosylated phenolphthiotriol dimycocerosatesactivemjackson2012-10-05
Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
OtherTBPWY:Phthiocerol dimycocerosates, PGL & pHBADactivemjackson2012-03-05
SAM-dependent O-methyltransferase involved in the formation of (phenol)phthiocerol dimycocerosates from (phenol)phthiodiolone dimycocerosates. Catalyzes the transfer of a methyl group to the third hydroxyl group of (phenol)phthiotriol in phthiocerol dimycocerosates and glycosylated phenolphthiotriol dimycocerosates (phenotypic [mycobacterial recombinant strains])
R. Siméone, P. Constant et al. Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis. FEBS J. 2007
OtherTBPWY:Phthiocerol dimycocerosates, PGL & pHBADactivemjackson2012-03-05
SAM-dependent O-methyltransferase involved in the formation of (phenol)phthiocerol dimycocerosates from (phenol)phthiodiolone dimycocerosates. Catalyzes the transfer of a methyl group to the third hydroxyl group of (phenol)phthiotriol in phthiocerol dimycocerosates and glycosylated phenolphthiotriol dimycocerosates (phenotypic [mycobacterial recombinant strains])
E. Pérez, P. Constant et al. Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex. J. Biol. Chem. 2004
TermEC:2.1.1.- Transferases. Transferring one-carbon groups. Methyltransferases. - NRactivejjmcfadden2012-03-05
Inferred from direct assay
E. Pérez, P. Constant et al. Characterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complex. J. Biol. Chem. 2004