Rv2981c - D-alanine-D-alanine ligase ddlA

Expression: Most Significant Conditions for Rv2981c

Protein Domains

Gene Information
Locus	Rv2981c
Symbol	ddl
Gene Name	D-alanine-D-alanine ligase ddlA
Location	3336796 - 3337917 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1122 bp Protein:374 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	32886
Related Genes	Acel_1586 BL0345 CE1431 cg1493 DIP1131 jk1217 MAP3019c MAV_3830 Mkms_1975 ML1678 Mmcs_1929 MSMEG_2395 MT3059 MUL_1976 Mvan_2143 nfa42050 PPA1359 SAV2679
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2981c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2981c Transcript 1
MSANDRRDRRVRVAVVFGGRSNEHAISCVSAGSILRNLDSRRFDVIAVGITPAGSWVLTD
ANPDALTITNRELPQVKSGSGTELALPADPRRGGQLVSLPPGAGEVLESVDVVFPVLHGP
YGEDGTIQGLLELAGVPYVGAGVLASAVGMDKEFTKKLLAADGLPVGAYAVLRPPRSTLH
RQECERLGLPVFVKPARGGSSIGVSRVSSWDQLPAAVARARRHDPKVIVEAAISGRELEC
GVLEMPDGTLEASTLGEIRVAGVRGREDSFYDFATKYLDDAAELDVPAKVDDQVAEAIRQ
LAIRAFAAIDCRGLARVDFFLTDDGPVINEINTMPGFTTISMYPRMWAASGVDYPTLLAT
MIETTLARGVGLH*

Genomic Sequence

>Rv2981c
GTGAGTGCTAACGACCGGCGTGATCGGCGTGTCCGCGTTGCCGTCGTGTTCGGCGGGCGC
AGCAACGAGCACGCCATCTCGTGTGTGTCCGCCGGCAGCATCCTGCGCAACCTGGACTCG
CGGCGGTTCGACGTGATCGCGGTGGGTATCACCCCGGCAGGTTCGTGGGTGCTCACCGAC
GCCAACCCCGACGCCCTGACGATCACCAACCGGGAGCTTCCTCAGGTCAAATCAGGATCG
GGCACCGAGCTGGCGCTGCCGGCCGATCCGCGGCGTGGTGGCCAGTTGGTGTCGCTGCCG
CCCGGGGCCGGCGAGGTTCTGGAGTCGGTCGACGTGGTGTTCCCGGTACTGCACGGCCCG
TACGGCGAGGACGGCACGATCCAGGGACTGCTCGAACTCGCCGGGGTGCCCTACGTGGGC
GCCGGTGTGCTGGCCAGTGCCGTCGGCATGGACAAGGAGTTCACCAAGAAGCTGCTCGCC
GCCGATGGACTTCCGGTGGGTGCGTACGCGGTGCTGCGTCCGCCGCGGTCGACACTGCAC
CGCCAGGAGTGCGAACGGCTGGGCTTACCGGTGTTCGTCAAACCCGCCCGAGGCGGCTCG
TCGATCGGTGTTAGCCGGGTGTCGAGTTGGGATCAACTGCCCGCCGCGGTCGCGCGGGCC
CGCCGGCATGACCCTAAGGTCATCGTCGAGGCCGCGATCAGCGGCCGCGAGCTGGAATGC
GGTGTGCTCGAAATGCCGGACGGCACACTGGAAGCCAGCACGCTGGGGGAGATCCGGGTG
GCCGGGGTGCGGGGACGCGAGGACTCTTTCTACGACTTCGCAACCAAGTATCTCGACGAC
GCAGCCGAATTGGACGTGCCCGCCAAGGTCGATGACCAGGTCGCAGAGGCGATTCGTCAG
CTGGCGATCCGGGCGTTCGCGGCTATCGACTGCCGGGGTCTGGCCAGGGTGGACTTCTTC
CTCACCGACGACGGTCCGGTGATCAACGAGATCAACACGATGCCGGGATTCACCACGATC
TCGATGTACCCGCGGATGTGGGCGGCCAGCGGTGTCGACTATCCGACCCTGCTGGCGACG
ATGATCGAGACGACATTGGCCCGCGGCGTGGGCCTGCACTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Name	D-alanine-D-alanine ligase A	active	mjackson	2012-10-05
	Peptidoglycan precursor synthesis
Term	EC:6.3.2.4 D-alanine--D-alanine ligase. - NR	active	extern:JZUCKER	2012-03-06
	Inferred from direct assay Z. Feng & RG. Barletta Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine. Antimicrob. Agents Chemother. 2003
Term	EC:6.3.2.4 D-alanine--D-alanine ligase. - NR	active	jjmcfadden	2012-03-05
	Inferred from direct assay Z. Feng & RG. Barletta Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine. Antimicrob. Agents Chemother. 2003