Rv3086 - zinc-type alcohol dehydrogenase adhD

Expression: Most Significant Conditions for Rv3086

Protein Domains

Gene Information
Locus	Rv3086
Symbol	adhD
Gene Name	zinc-type alcohol dehydrogenase adhD
Location	3451781 - 3452887 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1107 bp Protein:369 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	30797
Related Genes	MT3171
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3086
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3086 Transcript 1
MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPRFPIVGG
HEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYCCTGRQNLCDMGATILEGCMPDGS
FRFHSQGTDFGAMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAG
NLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASA
AAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTD
LTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGK
NIRGVIVH*

Genomic Sequence

>Rv3086
ATGAAAACCACCGCGGCGGTACTGTTCGAGGCGGGCAAACCGTTCGAGCTGATGGAGCTC
GATCTCGACGGGCCGGGTCCGGGCGAGGTGTTGGTCAAATACACCGCCGCCGGGCTGTGC
CATTCCGACCTGCACCTCACCGATGGTGATTTACCACCGCGGTTCCCGATCGTGGGCGGC
CACGAAGGGTCCGGGGTCATCGAGGAGGTGGGTGCCGGCGTCACCAGGGTCAAGCCCGGA
GACCACGTGGTGTGCAGCTTCATCCCGAACTGCGGGACTTGCCGCTACTGCTGCACCGGC
CGGCAGAACCTGTGCGACATGGGGGCCACCATCCTGGAGGGCTGCATGCCGGACGGCAGT
TTCCGATTCCATTCCCAGGGAACAGATTTCGGCGCCATGTGCATGCTGGGCACGTTCGCC
GAGCGGGCCACCGTCTCGCAGCATTCGGTGGTGAAGGTGGACGACTGGCTGCCACTGGAA
ACCGCGGTGCTGGTGGGCTGCGGCGTGCCGTCCGGTTGGGGCACCGCGGTCAATGCCGGA
AACCTGCGGGCCGGCGACACCGCCGTCATCTACGGCGTCGGCGGCCTGGGCATCAACGCG
GTCCAGGGCGCGACCGCCGCCGGCTGTAAGTACGTCGTGGTGGTGGACCCGGTGGCTTTC
AAGCGCGAGACCGCGCTCAAGTTCGGCGCCACCCATGCCTTCGCCGACGCCGCCAGCGCG
GCGGCCAAGGTCGACGAACTCACCTGGGGGCAGGGCGCCGACGCGGCGCTGATCCTGGTG
GGCACCGTCGACGACGAGGTGGTCTCGGCCGCGACCGCGGTGATCGGCAAGGGCGGCACC
GTCGTCATCACCGGGCTGGCGGACCCGGCCAAACTCACCGTGCACGTCTCCGGAACCGAT
TTGACGCTGCACGAGAAAACGATCAAGGGCTCGCTGTTCGGTTCCTGCAATCCGCAATAC
GACATCGTGCGGCTGCTGCGCCTCTACGACGCCGGCCAGCTGATGCTGGACGAACTCGTG
ACCACCACCTACAACCTCGAACAGGTGAACCAGGGCTACCAGGATCTGCGGGACGGCAAG
AACATTCGGGGCGTGATCGTGCACTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Transcription Rv3088	active	sourish10	2012-10-05
	Operon (Functional linkage) A. Singh, S. Jain et al. mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol. Lett. 2003
Interaction	Transcription Rv3082c	active	ilamathi.raja	2012-10-05
	Operon (Functional linkage) A. Singh, S. Jain et al. mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol. Lett. 2003
Interaction	Transcription Rv3082c	active	ilamathi.raja	2012-10-05
	Operon (Functional linkage) R. Singh, A. Singh et al. Deciphering the genes involved in pathogenesis of Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland) null
Interaction	Transcription Rv3085	active	sourish10	2012-10-05
	Co-expression (Functional linkage) A. Singh, S. Jain et al. mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol. Lett. 2003
Interaction	Transcription Rv3084	active	sourish10	2012-10-05
	Co-expression (Functional linkage) A. Singh, S. Jain et al. mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol. Lett. 2003
Interaction	Transcription Rv3083	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) A. Singh, S. Jain et al. mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol. Lett. 2003
Interaction	Transcription Rv3082c	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) A. Singh, S. Jain et al. mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol. Lett. 2003
Interaction	Transcription Rv3082c	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) P. Kumar, D. Kumar et al. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. J. Biol. Chem. 2009
Interaction	Transcription Rv3082c	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) A. Singh, R. Gupta et al. Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs. J. Bacteriol. 2005
Interaction	RegulatedBy Rv3082c	active	yamir.moreno	2012-10-05
	LacZ-promoter fusion. expression levels of LacZ- regulated promoter fusion measured and compared between wild-type and trans-element mutation (knockout, over expression etc.). Gfp-promoter fusion. expression levels of gfp-regulated promoter fusion measured and compared between wild-type and trans-element mutation (knockout, over expression etc.). A. Singh, S. Jain et al. mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol. Lett. 2003
Interaction	RegulatedBy Rv3082c	active	yamir.moreno	2012-10-05
	LacZ-promoter fusion. expression levels of LacZ- regulated promoter fusion measured and compared between wild-type and trans-element mutation (knockout, over expression etc.). Gfp-promoter fusion. expression levels of gfp-regulated promoter fusion measured and compared between wild-type and trans-element mutation (knockout, over expression etc.). A. Singh, S. Jain et al. mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol. Lett. 2003