Rv3197 - ABC transporter ATP-binding protein

Expression: Most Significant Conditions for Rv3197

Protein Domains

Gene Information
Locus	Rv3197
Symbol
Gene Name	ABC transporter ATP-binding protein
Location	3567024 - 3568367 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1344 bp Protein:448 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	33987
Related Genes	Acel_1769 MAP3295 MAV_4141 Mkms_1429 ML0640 Mmcs_1411 MSMEG_1954 MT3290 MUL_2510 Mvan_1810 nfa45310 SAV3068
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3197
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3197 Transcript 1
MDDGSVSDIKRGRAARNAKLASIPVGFAGRAALGLGKRLTGKSKDEVTAELMEKAANQLF
TVLGELKGGAMKVGQALSVMEAAIPDEFGEPYREALTKLQKDAPPLPASKVHRVLDGQLG
TKWRERFSSFNDTPVASASIGQVHKAIWSDGREVAVKIQYPGADEALRADLKTMQRMVGV
LKQLSPGADVQGVVDELVERTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVV
IQEWIEGVPMAEIIRHGTTEQRDLIGTLLAELTFDAPRRLGLMHGDAHPGNFMLLPDGRM
GIIDFGAVAPMPGGFPIELGMTIRLAREKNYDLLLPTMEKAGLIQRGRQVSVREIDEMLR
QYVEPIQVEVFHYTRKWLQKMTVSQIDRSVAQIRTARQMDLPAKLAIPMRVIASVGAILC
QLDAHVPIKALSEELIPGFAEPDAIVV*

Genomic Sequence

>Rv3197
ATGGATGATGGGAGTGTGTCAGATATCAAACGGGGCCGCGCCGCGCGCAATGCGAAGCTG
GCCAGCATCCCGGTCGGCTTCGCCGGTCGGGCGGCGCTCGGGCTCGGCAAGCGACTGACC
GGTAAGTCAAAAGACGAGGTTACCGCCGAGCTGATGGAGAAGGCCGCCAATCAGTTGTTT
ACCGTCCTCGGCGAACTCAAGGGTGGCGCGATGAAGGTCGGCCAGGCGCTGTCGGTGATG
GAGGCCGCCATTCCCGACGAGTTCGGCGAACCCTACCGGGAAGCACTGACCAAGCTGCAG
AAGGACGCCCCACCGCTGCCCGCCAGTAAGGTGCACCGGGTACTCGACGGACAGCTGGGC
ACCAAATGGCGGGAGCGGTTCAGCTCGTTCAACGACACCCCAGTGGCATCTGCCAGCATC
GGCCAGGTGCACAAAGCAATCTGGTCGGACGGCCGAGAAGTGGCCGTCAAGATCCAGTAT
CCCGGCGCCGACGAGGCGCTGCGCGCGGACCTCAAGACCATGCAGCGCATGGTCGGCGTG
CTCAAACAGCTCTCACCCGGCGCCGACGTCCAAGGGGTGGTCGACGAACTGGTTGAACGC
ACCGAAATGGAACTCGACTACCGGCTGGAGGCCGCCAACCAGCGCGCCTTCGCCAAGGCG
TACCACGACCACCCGCGCTTCCAGGTGCCTCACGTCGTGGCAAGCGCACCGAAGGTGGTG
ATCCAGGAGTGGATCGAAGGTGTGCCGATGGCAGAGATCATCCGTCACGGGACCACCGAG
CAGCGTGATCTGATCGGTACGCTGCTCGCCGAGCTCACCTTCGACGCACCACGGCGGCTG
GGGTTGATGCACGGCGACGCCCACCCCGGTAATTTCATGCTGCTGCCCGACGGCCGGATG
GGCATCATCGACTTCGGTGCCGTGGCACCGATGCCCGGCGGCTTCCCGATAGAGCTCGGG
ATGACGATTCGACTGGCCCGCGAGAAGAACTACGACCTCCTGTTGCCGACGATGGAGAAG
GCCGGGTTGATCCAGCGAGGACGACAGGTGTCGGTTCGCGAGATCGACGAGATGCTGCGC
CAATACGTCGAGCCCATCCAGGTCGAGGTCTTCCACTACACCCGCAAGTGGTTACAGAAA
ATGACCGTCAGTCAGATCGACCGCTCGGTTGCGCAGATCAGAACGGCGCGCCAGATGGAC
CTGCCGGCCAAGCTCGCGATTCCGATGCGGGTTATCGCATCGGTGGGCGCGATCCTATGC
CAGCTGGACGCGCATGTGCCGATCAAGGCCCTGTCGGAGGAGCTGATCCCGGGTTTCGCC
GAGCCCGACGCGATCGTCGTCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	RegulatedBy Rv2711	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008