Rv3290c - L-lysine-epsilon aminotransferase lat

Expression: Most Significant Conditions for Rv3290c

Protein Domains

Gene Information
Locus	Rv3290c
Symbol	lat
Gene Name	L-lysine-epsilon aminotransferase lat
Location	3670445 - 3671794 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1350 bp Protein:450 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	34751
Related Genes	Acel_0230 MAP3410c MAV_4262 Mkms_1289 Mmcs_1272 MSMEG_1764 MT3389 MUL_2644 Mvan_1652 nfa9840 SAV1645
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3290c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3290c Transcript 1
MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMF
TFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALP
HLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNT
KPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPI
QGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGK
KTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQH
GKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADT
VRFRPPLTVSTAEIDAAIAAVRSALPVVT*

Genomic Sequence

>Rv3290c
ATGGCCGCCGTCGTGAAGTCCGTCGCTCTTGCCGGTAGACCAACAACACCAGACCGGGTT
CATGAGGTGCTAGGGCGCAGCATGCTGGTCGACGGTCTGGACATAGTGCTCGATCTGACC
CGTTCGGGCGGTTCATATCTGGTCGACGCTATAACGGGTCGGCGCTACCTGGACATGTTC
ACATTCGTTGCCTCCTCGGCACTGGGTATGAATCCCCCGGCGCTGGTGGACGACCGGGAG
TTCCATGCCGAACTCATGCAGGCCGCGCTGAACAAGCCCAGCAATTCCGACGTGTACTCG
GTGGCGATGGCCCGCTTCGTCGAGACCTTCGCCCGTGTCTTGGGCGACCCGGCGCTGCCG
CATCTGTTCTTCGTCGAAGGGGGCGCCCTGGCGGTGGAGAACGCGCTCAAAGCCGCGTTC
GACTGGAAGAGTCGGCACAACCAAGCCCATGGGATCGACCCGGCGCTGGGCACTCAAGTG
CTCCACCTGCGCGGGGCATTTCACGGCCGCAGCGGCTATACCCTGTCGCTGACCAACACC
AAGCCGACCATTACCGCCCGGTTCCCGAAATTCGACTGGCCACGCATCGATGCGCCGTAC
ATGCGGCCCGGCCTGGATGAGCCCGCTATGGCCGCGCTAGAGGCCGAGGCGCTACGCCAG
GCCCGCGCGGCATTCGAGACCCGCCCGCACGACATCGCGTGTTTTGTGGCCGAACCCATC
CAGGGCGAGGGTGGCGACCGCCATTTCCGCCCGGAGTTTTTCGCTGCGATGCGCGAGCTG
TGCGACGAGTTTGATGCACTGCTGATCTTCGACGAAGTACAGACCGGCTGCGGGTTGACC
GGAACCGCCTGGGCATACCAGCAGTTGGATGTCGCACCCGACATCGTGGCGTTCGGCAAG
AAGACGCAGGTATGCGGAGTGATGGCCGGTCGGCGGGTGGACGAGGTCGCCGACAATGTG
TTCGCGGTCCCATCACGGCTCAACTCGACATGGGGTGGCAATCTTACCGACATGGTGCGC
GCCCGCCGCATCTTGGAGGTCATCGAAGCCGAGGGCCTGTTCGAGCGGGCGGTGCAGCAC
GGTAAGTATCTGCGCGCCCGGCTTGACGAACTCGCCGCGGACTTCCCGGCAGTGGTTCTC
GATCCGCGCGGCCGCGGGCTGATGTGTGCGTTTAGCCTGCCGACCACCGCCGACCGTGAC
GAGTTGATCCGCCAGCTGTGGCAACGTGCGGTGATTGTGTTGCCGGCCGGTGCAGACACC
GTGCGATTCCGTCCACCGCTGACGGTTTCAACCGCCGAGATCGACGCCGCGATAGCCGCG
GTGCGCAGCGCGTTACCGGTGGTGACGTAA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:ABTA 4-aminobutyrate transaminase - ISS	active	njamshidi	2012-10-05
	No strong evidence - at present inferred. This view is supported/argued for in PMID: 16027371 J. Tian, R. Bryk et al. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 2005
Term	EC:2.6.1.19 4-aminobutyrate transaminase. - ISS	active	njamshidi	2012-10-05
	No strong evidence - at present inferred. This view is supported/argued for in PMID: 16027371 J. Tian, R. Bryk et al. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 2005
Interaction	PhysicalInteraction Rv3291c	active	vijayachitra	2012-10-05
	Structural Analysis MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
Interaction	PhysicalInteraction Rv3291c	active	vijayachitra	2012-10-05
	Structural Analysis T. Shrivastava & R. Ramachandran Mechanistic insights from the crystal structures of a feast/famine regulatory protein from Mycobacterium tuberculosis H37Rv. Nucleic Acids Res. 2007
Interaction	PhysicalInteraction Rv3291c	active	vijayachitra	2012-10-05
	Spectrophotometric MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
Interaction	PhysicalInteraction Rv3291c	active	vijayachitra	2012-10-05
	Spectrophotometric T. Shrivastava & R. Ramachandran Mechanistic insights from the crystal structures of a feast/famine regulatory protein from Mycobacterium tuberculosis H37Rv. Nucleic Acids Res. 2007
Interaction	Regulatory Rv3289c	active	vashishtrv	2012-10-05
	Operon (Functional linkage) MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
Interaction	Regulatory Rv3289c	active	shahanup86	2012-10-05
	Operon (Functional linkage) MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
Interaction	Regulatory Rv3288c	active	vashishtrv	2012-10-05
	Operon (Functional linkage) MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
Interaction	Regulatory Rv3288c	active	shahanup86	2012-10-05
	Operon (Functional linkage) MC. Reddy, K. Gokulan et al. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Sci. 2008
Interaction	RegulatedBy Rv0182c	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. JH. Lee, DE. Geiman et al. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J. Bacteriol. 2008
Interaction	RegulatedBy Rv3286c	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. EP. Williams, JH. Lee et al. Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1. J. Bacteriol. 2007