Rv3297 - endonuclease VIII nei

Expression: Most Significant Conditions for Rv3297

Protein Domains

Gene Information
Locus	Rv3297
Symbol	nei
Gene Name	endonuclease VIII nei
Location	3681320 - 3682087 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:768 bp Protein:256 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	25198
Related Genes	MAP3416 Mkms_1282 Mmcs_1265 MSMEG_1756 MT3396 MUL_2650 Mvan_1631 nfa9770 SAV2501
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3297
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3297 Transcript 1
MPEGDTVWHTAATLRRHLAGRTLTRCDIRVPRFAAVDLTGEVVDEVISRGKHLFIRTGTA
SIHSHLQMDGSWRVGNRPVRVDHRARIILEANQQEQAIRVVGVDLGLLEVIDRHNDGAVV
AHLGPDLLADDWDPQRAAANLIVAPDRPIAEALLDQRVLAGIGNVYCNELCFVSGVLPTA
PVSAVADPRRLVTRARDMLWVNRFRWNRCTTGDTRAGRRLWVYGRAGQGCRRCGTLIAYD
TTDERVRYWCPACQR*

Genomic Sequence

>Rv3297
ATGCCCGAGGGCGACACCGTCTGGCACACCGCGGCCACGTTGCGGCGGCATCTGGCCGGT
CGCACGTTGACACGTTGCGACATCCGAGTGCCACGGTTTGCCGCCGTCGACCTCACCGGC
GAGGTAGTGGACGAGGTGATCAGTCGGGGCAAGCACCTGTTCATCCGAACCGGGACAGCC
AGCATTCATTCGCATCTGCAGATGGACGGCAGCTGGCGGGTCGGCAACAGGCCGGTGCGG
GTGGATCATCGGGCGCGAATCATTTTGGAAGCCAACCAGCAAGAACAGGCCATCCGGGTG
GTCGGCGTCGACCTAGGCCTGTTGGAGGTCATCGACCGGCACAACGACGGCGCCGTCGTC
GCACACCTAGGACCTGATCTGCTGGCCGACGATTGGGACCCGCAGCGTGCAGCCGCCAAC
CTGATCGTTGCCCCGGACCGGCCCATCGCCGAGGCACTGCTCGACCAGCGGGTGCTCGCC
GGGATCGGCAACGTGTATTGCAACGAACTGTGCTTCGTCAGCGGAGTATTGCCGACGGCC
CCGGTGAGCGCGGTCGCCGACCCGCGCCGCCTGGTCACCCGCGCCCGAGACATGCTGTGG
GTCAACCGCTTCCGCTGGAATCGGTGCACCACTGGCGATACCCGGGCCGGCCGGCGACTG
TGGGTCTACGGGCGGGCCGGGCAGGGTTGCCGCCGCTGCGGCACGCTCATCGCCTACGAC
ACTACCGACGAGCGGGTGCGGTATTGGTGCCCGGCCTGCCAGCGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Other	TBPWY:Base excision repair (BER)	active	vmizrahi	2012-03-05
	Over-expressed at high level using a novel bicistronic expression vector
Other	TBPWY:Base excision repair (BER)	active	vmizrahi	2012-03-05
	Nei2 did not demonstrate activity in vitro as a recombinant protein. However, like Nei1 when expressed in E. coli, it decreased the spontaneous mutation frequency of both the fpg mutY nei triple and nei nth double mutants, suggesting that Nei2 is functionally active in vivo recognizing both guanine and cytosine oxidation products
Symbol	nei2	active	vmizrahi	2012-03-05
	Nei2 did not demonstrate activity in vitro as a recombinant protein. However, like Nei1 when expressed in E. coli, it decreased the spontaneous mutation frequency of both the fpg mutY nei triple and nei nth double mutants, suggesting that Nei2 is functionally active in vivo recognizing both guanine and cytosine oxidation products