Rv3370c - DNA polymerase III alpha chain dnaE2

Expression: Most Significant Conditions for Rv3370c

Protein Domains

Gene Information
Locus	Rv3370c
Symbol	dnaE2
Gene Name	DNA polymerase III alpha chain dnaE2
Location	3781501 - 3784740 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:3240 bp Protein:1080 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	256
Related Genes	Acel_0995 CE0632 cg0738 DIP0612 jk1709 MAP3476c MAV_4335 Mkms_1200 Mmcs_1183 MSMEG_1633 MT3480 MUL_0923 Mvan_1530 nfa9150 PPA1650 SAV6555
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3370c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3370c Transcript 1
MERVLNGKPRHAGVPAFDADGDVPRSRKRGAYQPPGRERVGSSVAYAELHAHSAYSFLDG
ASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGATARTER
PDPPGPHLLVLARGPEGYRRLSRQLAAAHLAGGEKGKPRYDFDALTEAAGGHWHILTGCR
KGHVRQALSQGGPAAAQRALADLVDRFTPSRVSIELTHHGHPLDDERNAALAGLAPRFGV
GIVATTGAHFADPSRGRLAMAMAAIRARRSLDSAAGWLAPLGGAHLRSGEEMARLFAWCP
EAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWLRSLVMAGARERYGPPKSAPRA
YSQIEHELKVIAQLRFPGYFLVVHDITRFCRDNDILCQGRGSAANSAVCYALGVTAVDPV
ANELLFERFLSPARDGPPDIDIDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAV
RDMARALGFSPGQQDAWSKQVSHWTGQADDVDGIPEQVIDLATQIRNLPRHLGIHSGGMV
ICDRPIADVCPVEWARMANRSVLQWDKDDCAAIGLVKFDLLGLGMLSALHYAKDLVAEHK
GIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRP
GPIQGGSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEA
DQLRRAMGSKRSTERMRRLRGRFYDGMRALHGAPDEVIDRIYEKLEAFANFGFPESHALS
FASLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHGVAVHGPCVNASLAHA
TCENAGTEVRLGLGAVRYLGAELAEKLVAERTANGPFTSLPDLTSRVQLSVPQVEALATA
GALGCFGMSRREALWAAGAAATGRPDRLPGVGSSSHIPALPGMSELELAAADVWATGVSP
DSYPTQFLRADLDAMGVLPAERLGSVSDGDRVLIAGAVTHRQRPATAQGVTFINLEDETG
MVNVLCTPGVWARHRKLAHTAPALLIRGQVQNASGAITVVAERMGRLTLAVGARSRDFR*

Genomic Sequence

>Rv3370c
ATGGAACGGGTGCTTAACGGCAAGCCGCGCCATGCCGGGGTGCCGGCGTTCGACGCGGAT
GGGGACGTCCCACGGTCCCGCAAGCGCGGGGCGTACCAGCCGCCGGGCCGGGAACGGGTC
GGATCGTCCGTCGCGTATGCCGAGCTGCATGCGCATTCGGCGTACAGCTTCCTCGACGGG
GCCAGCACGCCCGAGGAGTTGGTCGAGGAGGCCGCCCGGCTGGGCCTGTGTGCCCTGGCG
CTGACCGACCACGACGGCCTGTACGGGGCGGTGCGGTTCGCCGAAGCGGCCGCGGAACTC
GACGTGCGCACGGTCTTCGGCGCCGAGCTGTCACTGGGCGCCACGGCTCGCACCGAGCGG
CCGGATCCGCCCGGCCCGCACCTGCTGGTGTTGGCCCGCGGCCCGGAAGGCTACCGGCGG
TTGTCGCGGCAACTGGCGGCGGCGCATCTGGCCGGCGGCGAAAAGGGTAAGCCGCGCTAC
GACTTCGACGCGCTAACCGAGGCCGCCGGCGGGCACTGGCACATCCTGACTGGCTGCCGC
AAAGGCCATGTGCGCCAAGCGCTTTCCCAGGGTGGCCCGGCCGCGGCGCAGCGGGCGCTG
GCCGATCTGGTGGACCGGTTCACCCCCAGCCGGGTCAGCATCGAGCTGACCCATCATGGT
CACCCGCTCGACGACGAACGCAACGCCGCGCTGGCCGGACTGGCGCCGCGCTTCGGTGTC
GGCATCGTCGCCACCACCGGGGCGCACTTCGCGGATCCGTCACGTGGGCGGCTGGCGATG
GCGATGGCGGCCATCCGGGCCCGGCGGTCGCTGGACTCCGCGGCCGGGTGGCTGGCTCCG
CTGGGTGGGGCGCACCTGCGGTCCGGGGAGGAGATGGCCCGGTTGTTCGCGTGGTGCCCC
GAGGCGGTGACCGCGGCCGCCGAGCTCGGCGAGCGGTGCGCCTTTGGCCTACAGCTCATC
GCGCCGCGGCTGCCGCCGTTCGATGTTCCCGACGGGCACACCGAGGACAGCTGGCTGCGG
TCGTTGGTCATGGCGGGCGCCCGCGAGCGTTACGGGCCGCCCAAGAGCGCGCCCCGGGCG
TACTCCCAGATCGAGCATGAGCTGAAAGTCATTGCCCAACTGAGATTTCCGGGCTACTTC
CTGGTGGTGCACGACATCACCCGGTTTTGCCGGGACAACGACATCCTGTGTCAGGGCAGG
GGATCGGCGGCCAACTCCGCGGTCTGCTATGCCCTGGGCGTCACCGCCGTCGACCCGGTG
GCCAACGAGCTGTTGTTCGAGCGCTTCTTATCGCCCGCCCGCGACGGGCCACCCGACATC
GACATCGACATCGAGTCGGATCAGCGCGAAAAGGTCATCCAGTACGTCTACCACAAATAC
GGCCGCGACTACGCCGCCCAGGTCGCCAACGTCATCACCTACCGGGGGCGCAGCGCGGTG
CGTGACATGGCCCGCGCCCTGGGCTTCTCGCCGGGCCAGCAGGACGCGTGGAGCAAGCAG
GTCAGCCACTGGACCGGGCAGGCCGACGACGTTGACGGCATCCCCGAGCAGGTGATCGAC
CTGGCCACCCAGATCCGCAACCTGCCGCGGCACCTAGGCATCCACTCCGGCGGCATGGTC
ATCTGCGACCGCCCGATCGCCGACGTGTGCCCGGTGGAATGGGCGCGCATGGCCAACCGC
AGCGTCCTGCAATGGGACAAAGACGACTGCGCGGCAATCGGCTTGGTGAAATTCGACCTA
CTCGGGCTGGGCATGCTCTCGGCGCTGCACTATGCGAAAGACCTGGTGGCCGAGCACAAG
GGCATCGAGGTGGACCTGGCCCGCCTCGACCTCTCCGAGCCGGCGGTGTATGAGATGCTG
GCCCGCGCCGATTCCGTCGGCGTGTTCCAGGTGGAGTCACGTGCGCAGATGGCCACCCTG
CCGCGCCTTAAGCCGCGAGTGTTCTACGACCTGGTGGTGGAGGTGGCGCTGATCCGCCCC
GGGCCCATCCAGGGCGGATCGGTGCACCCCTACATCCGGCGGCGCAACGGCGTCGACCCG
GTCATCTACGAGCACCCGTCGATGGCGCCGGCATTGCGAAAGACGCTGGGAGTGCCGCTG
TTTCAGGAGCAGCTGATGCAGTTGGCGGTCGACTGCGCCGGCTTTTCCGCCGCCGAGGCC
GACCAGCTGCGCCGCGCCATGGGGTCCAAACGCTCCACCGAACGCATGCGCCGGCTGCGC
GGCCGGTTCTACGACGGCATGCGCGCGCTGCACGGCGCCCCCGACGAGGTGATCGACCGG
ATCTACGAAAAGCTGGAGGCGTTTGCCAATTTCGGCTTCCCCGAGAGCCACGCACTGAGT
TTCGCGTCGCTGGTGTTCTACTCGGCGTGGTTCAAGCTGCACCACCCGGCGGCGTTCTGT
GCGGCGCTGCTGCGCGCCCAGCCGATGGGTTTCTATTCGCCGCAGTCGCTGGTGGCCGAC
GCCCGCCGGCACGGCGTGGCGGTGCACGGCCCGTGTGTCAATGCCAGCCTGGCGCACGCC
ACGTGTGAGAACGCCGGAACGGAGGTGCGTTTGGGCTTGGGCGCCGTCCGCTACCTCGGC
GCCGAGCTGGCCGAGAAGCTGGTCGCGGAGCGAACAGCCAACGGCCCGTTCACCTCCCTG
CCGGACTTGACGTCGCGGGTGCAGCTTTCCGTGCCGCAGGTCGAAGCGCTGGCGACGGCC
GGGGCGCTGGGCTGCTTCGGCATGTCTCGGCGGGAGGCGCTGTGGGCGGCCGGGGCCGCG
GCCACGGGCCGGCCGGACCGGTTACCCGGGGTGGGCTCGTCGTCGCACATCCCGGCGCTG
CCGGGGATGAGCGAGCTGGAGCTGGCCGCCGCCGACGTGTGGGCCACCGGCGTCTCCCCG
GACAGCTATCCGACCCAGTTCCTGCGGGCGGACCTGGACGCGATGGGGGTGCTGCCCGCC
GAGAGGCTGGGATCGGTGTCCGACGGCGACCGCGTGCTGATCGCCGGCGCGGTGACTCAT
CGGCAGCGACCCGCCACGGCCCAGGGGGTGACGTTCATCAACCTCGAAGACGAGACCGGG
ATGGTCAACGTGCTCTGCACGCCCGGGGTGTGGGCGCGACACCGCAAGCTCGCGCACACG
GCGCCGGCGCTGCTGATCCGCGGCCAGGTCCAAAACGCCAGCGGCGCAATCACCGTCGTC
GCCGAACGGATGGGCCGCCTCACCCTGGCGGTCGGCGCGCGCTCGCGCGACTTCCGGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv2720	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Other	TBPWY:Translesion synthesis	active	vmizrahi	2012-03-05
Other	TBPWY:Translesion synthesis	active	vmizrahi	2012-03-05
	Part of imuA-imuB-dnaE2-type mutagenic cassette. Mutation of catalytic aspartates reproduces dnaE2 deletion phenotype (abrogation of damage-induced mutagenesis and enhances sensitivity to DNA damaging agents)