Rv3457c - DNA-directed RNA polymerase alpha chain rpoA

Expression: Most Significant Conditions for Rv3457c

Protein Domains

Gene Information
Locus	Rv3457c
Symbol	rpoA
Gene Name	DNA-directed RNA polymerase alpha chain rpoA
Location	3877464 - 3878507 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1044 bp Protein:348 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	32704
Related Genes	Acel_0334 BL1606 CE0572 cg0655 DIP0549 jk1758 MAP4233 MAV_4398 Mkms_1130 ML1957 Mmcs_1113 MSMEG_1524 MT3564 MUL_0848 Mvan_1436 nfa8370 PPA1826 SAV4953
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3457c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3457c Transcript 1
MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVL
HEFTTVPGVKEDVTEIILNLKSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHN
PGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIGRIPVDSIYSPVLKVTYKVDA
TRVEQRTDFDKLILDVETKNSISPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAE
ADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIK
LHQLGLSLKDSPPSFDPSEVAGYDVATGTWSTEGAYDEQDYAETEQL*

Genomic Sequence

>Rv3457c
ATGCTGATCTCACAGCGCCCCACCCTGTCCGAGGACGTCCTCACCGACAACCGATCCCAG
TTCGTGATCGAACCGCTGGAGCCGGGATTCGGCTACACCCTGGGCAATTCGCTGCGTCGC
ACCCTGCTGTCGTCGATTCCCGGAGCGGCCGTCACCAGCATTCGCATCGATGGTGTACTG
CACGAATTCACCACGGTGCCCGGGGTCAAAGAAGATGTCACCGAGATCATCCTGAATCTC
AAGAGCCTGGTGGTGTCCTCGGAGGAGGACGAGCCGGTCACCATGTACCTACGCAAGCAG
GGTCCGGGTGAGGTTACCGCCGGCGACATCGTGCCGCCGGCCGGCGTCACCGTGCACAAC
CCCGGCATGCACATCGCCACGCTGAACGATAAGGGCAAGCTGGAAGTCGAGCTCGTCGTC
GAGCGTGGCCGCGGCTATGTCCCGGCGGTGCAAAACCGGGCTTCGGGTGCCGAAATTGGG
CGCATTCCAGTCGATTCCATCTACTCACCGGTGCTCAAAGTGACCTACAAGGTGGACGCC
ACCCGGGTCGAGCAGCGCACCGACTTCGACAAGCTGATCCTGGACGTGGAGACCAAGAAT
TCAATCAGCCCGCGCGACGCGCTGGCGTCGGCTGGCAAGACGCTGGTCGAGTTGTTCGGC
CTGGCACGGGAACTCAACGTCGAGGCCGAAGGCATCGAGATCGGGCCGTCGCCGGCCGAG
GCCGATCACATTGCGTCATTCGCCCTGCCGATCGACGACCTGGATCTGACGGTGCGGTCC
TACAACTGCCTCAAGCGCGAGGGGGTGCACACCGTGGGCGAACTGGTGGCGCGCACCGAA
TCCGACCTGCTTGACATCCGCAACTTCGGTCAGAAGTCCATCGACGAGGTGAAGATCAAG
CTGCACCAGCTGGGCCTGTCACTCAAGGACAGCCCGCCGAGCTTCGACCCCTCGGAGGTC
GCGGGCTACGACGTCGCCACCGGCACCTGGTCGACCGAGGGCGCGTACGACGAGCAGGAC
TACGCCGAAACCGAACAGCTTTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv0668	active	prabhakarsmail	2012-10-05
	Kinetic Assays LP. Miller, JT. Crawford et al. The rpoB gene of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 1994
Interaction	PhysicalInteraction Rv0667	active	prabhakarsmail	2012-10-05
	Kinetic Assays LP. Miller, JT. Crawford et al. The rpoB gene of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 1994
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009