Rv3494c - MCE-family protein mce4F

Expression: Most Significant Conditions for Rv3494c

Protein Domains

Gene Information
Locus	Rv3494c
Symbol	mce4F
Gene Name	MCE-family protein mce4F
Location	3911675 - 3913369 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1695 bp Protein:565 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	22737
Related Genes	MAP0569 Mkms_4700 Mmcs_4612 MSMEG_5895 MT3598 MUL_4057 Mvan_5197 nfa5420
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3494c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3494c Transcript 1
MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSADFVAGGGLYKNANVTY
RGVAVGRVESVGLNPNGVTAHMRLNSGTAIPSNVTATVRSVSAIGEQYIDLVPPENPSST
KLRNGFRIQRQNTRIGQDVADLLRQAETLLGSLGDTRLRELLHEAFIATNGAGPELARLI
ESARLLVDEANANYPQVSQLIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLR
DTLADAPDAIDEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALFAAII
TSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPPLVRSPADESVREIPRDMYCKTAQNDP
STVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTNPWRGPPIPYGTEVTDGRNILPPN
KFPYIPPGADPDPGVPIVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGY
PPEPPQVPYPATIPPPPPPEGTGPPPGPAPGPQPQASGPAYTIYDQLSGAFADPAGGTGI
FAPGMTGASSAENWVDLMRDPRQL*

Genomic Sequence

>Rv3494c
ATGATCGACCGACTCGCCAAGATCCAGTTGTCCATTTTTGCGGTGATCACCGTCATCACC
CTGAGCGTGATGGCGATCTTTTATCTGCGTCTGCCCGCCACGTTCGGCATCGGAACCTAC
GGCGTGAGTGCCGACTTCGTCGCGGGCGGTGGCCTGTACAAGAACGCCAACGTCACCTAC
CGCGGTGTCGCGGTCGGGCGGGTGGAGTCGGTGGGGCTAAATCCCAATGGCGTTACCGCG
CACATGCGACTGAACAGTGGCACCGCCATTCCGTCGAACGTCACCGCCACCGTACGCAGC
GTTTCGGCCATCGGTGAGCAGTACATCGACCTAGTGCCGCCGGAGAACCCGTCGTCGACC
AAGTTGCGCAACGGCTTCCGGATCCAGCGGCAGAACACCCGAATCGGGCAAGACGTCGCC
GACCTGTTGCGTCAGGCCGAGACGCTGCTCGGCAGCCTTGGCGACACCCGGCTGCGGGAG
CTGCTGCACGAGGCGTTCATCGCGACCAATGGCGCCGGTCCGGAACTGGCCCGGCTGATC
GAGTCGGCCCGGTTGCTGGTGGATGAGGCCAACGCCAACTATCCACAGGTTTCGCAGTTG
ATCGATCAGGCCGGCCCGTTCCTGCAAGCCCAGATCCGCGCCGGCGGGGACATCAAGTCA
CTCGCCGATGGGCTGGCGCGGTTCACCTGGCAGCTCCGTGCGGCAGACCCGCGGCTGCGC
GACACGTTGGCCGACGCCCCGGATGCGATCGACGAGGCCAACACCGCGTTCTCCGGGATT
CGTCCTTCGTTTCCCGCGCTGGCGGCCAGTCTGGCCAACCTGGGCCGGGTGGGCGTGATC
TATCACAAGTCGATCGAACAGCTCCTGGTGGTTTTCCCGGCGCTGTTCGCCGCGATCATC
ACCTCGGCGGGCGGCGTACCCCAGGACGAGGGCGCCAAGCTGGACTTCAAGATCGACCTG
CACGACCCGCCGCCCTGCATGACCGGGTTCTTGCCCCCGCCGCTGGTCCGGTCGCCGGCC
GACGAGTCGGTACGCGAGATTCCCCGGGACATGTACTGCAAGACCGCGCAGAACGACCCG
AGCACGGTGCGCGGCGCTCGCAACTACCCGTGCCAGGAATTCCCCGGTAAGCGGGCACCG
ACGGTGCAGTTATGTCGGGATCCGCGTGGCTATGTGCCAGTTGGAACCAACCCGTGGCGC
GGTCCGCCGATCCCGTACGGCACCGAGGTGACGGATGGGCGAAACATTCTGCCGCCCAAC
AAGTTCCCTTACATCCCGCCGGGCGCGGATCCCGACCCGGGCGTGCCCATCGTCGGACCG
CCGCCACCCGGCCAGGTGGCCGGCCCCGGGCCGGCGCCGCACCAGCCGGCGCAGCCTGCG
CCGCCGCCCAACGACAACGGTCCGCCTCCACCGTTCACGTCATGGATGCCGCCCGGGTAC
CCGCCGGAGCCACCCCAGGTGCCATACCCGGCGACCATTCCGCCGCCGCCACCACCGGAA
GGCACCGGGCCTCCGCCCGGGCCGGCGCCTGGCCCCCAACCGCAGGCCAGCGGTCCGGCC
TACACCATCTATGACCAACTCAGCGGAGCCTTCGCGGACCCGGCCGGCGGCACTGGTATC
TTCGCGCCCGGGATGACGGGCGCATCCAGCGCCGAGAATTGGGTGGATCTCATGCGCGAT
CCGAGGCAGCTGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	Regulatory Rv3574	active	akankshajain.21	2012-10-05
	Co-expression (Functional linkage) authors,R. Van der Geize,K. Yam,T. Heuser,MH. Wilbrink,H. Hara,MC. Anderton,E. Sim,L. Dijkhuizen,JE. Davies,WW. Mohn,LD. Eltis A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc. Natl. Acad. Sci. U.S.A. 2007
Interaction	Regulatory Rv3574	active	akankshajain.21	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	M.smegmatis orthology based inference. Orthologous pair regulator-target found in M.smegmatis. SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008