Rv3534c - 4-hydroxy-2-oxovalerate aldolase

Expression: Most Significant Conditions for Rv3534c

Protein Domains

Gene Information
Locus	Rv3534c
Symbol
Gene Name	4-hydroxy-2-oxovalerate aldolase
Location	3972552 - 3973592 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1041 bp Protein:347 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	25433
Related Genes	MAP0533 MAV_0627 Mkms_4747 Mmcs_4659 MSMEG_5937 MT3638 MUL_4095 Mvan_5234 nfa4670
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3534c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3534c Transcript 1
MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPVIEVTHGDGLGGSSFNY
GFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVS
IQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVAD
RVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEAL
IGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKHAVRQA
ERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVTH*

Genomic Sequence

>Rv3534c
ATGACCGATATGTGGGACGTCCGCATCACGGACACCTCGCTGCGGGATGGGTCGCACCAC
AAACGCCACCAATTCACCAAGGACGAGGTCGGTGCCATCGTGGCCGCCCTAGACGCCGCT
GGCGTGCCGGTGATCGAGGTGACCCACGGCGACGGCCTGGGCGGCTCATCGTTCAACTAT
GGCTTCTCGAAAACCCCTGAGCAGGAGCTGATCAAGCTGGCCGCGGCGACCGCGAAAGAG
GCCCGGATCGCGTTTTTGATGTTGCCCGGTGTGGGCACCAAGGACGACATCAAAGAGGCG
CGGGACAACGGCGGGTCGATCTGCCGGATCGCCACCCACTGCACCGAGGCCGACGTGTCG
ATCCAGCATTTCGGGCTGGCCCGCGAACTGGGTCTGGAAACCGTCGGGTTTTTGATGATG
GCCCACACCATTGCGCCGGAGAAACTGGCCGCCCAGGCCCGCATCATGGCCGACGCCGGC
TGCCAGTGTGTCTACGTCGTCGACTCCGCCGGTGCCCTGGTGCTCGACGGCGTGGCCGAC
CGGGTGTCGGCCCTGGTCGCCGAGCTCGGCGAAGACGCCCAGGTGGGCTTTCATGGGCAC
GAGAACCTCGGTCTCGGGGTGGCCAATTCGGTGGCGGCGGTGCGCGCGGGCGCCAAGCAG
ATCGACGGGTCCTGCCGGCGTTTCGGCGCCGGGGCGGGTAACGCGCCGGTCGAGGCGCTG
ATCGGGGTGTTCGACAAGATCGGCGTCAAGACCGGCATTGATTTCTTCGACATTGCCGAC
GCCGCCGAGGACGTGGTGCGCCCGGCCATGCCGGCCGAATGTCTGCTCGACCGCAACGCG
TTGATCATGGGGTATTCCGGGGTCTACTCCAGCTTCCTCAAGCATGCGGTCCGCCAGGCC
GAGCGCTACGGCGTGCCGGCGTCGGCGCTGTTGCACCGGGCCGGTCAGCGCAAGCTCATC
GGTGGCCAGGAAGACCAGCTCATCGACATCGCGCTGGAAATCAAACGCGAGCTGGATAGC
GGTGCGGCCGTAACGCATTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	M.smegmatis orthology based inference. Orthologous pair regulator-target found in M.smegmatis. SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Term	EC:4.1.3.- Lyases. Carbon-carbon lyases. Oxo-acid-lyases. - NR	active	nsampson	2012-03-05
	Human inference of function by sequence orthology authors,R. Van der Geize,K. Yam,T. Heuser,MH. Wilbrink,H. Hara,MC. Anderton,E. Sim,L. Dijkhuizen,JE. Davies,WW. Mohn,LD. Eltis A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc. Natl. Acad. Sci. U.S.A. 2007