Rv3822 - conserved hypothetical protein

Expression: Most Significant Conditions for Rv3822

Protein Domains

Gene Information
Locus	Rv3822
Symbol
Gene Name	conserved hypothetical protein
Location	4286721 - 4287935 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1215 bp Protein:405 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	12704
Related Genes	Mkms_0258 Mmcs_0248 MSMEG_0412 MT3930 Mvan_0276
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3822
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3822 Transcript 1
MKCPGVSDCVATVRHDNVFAIAAGLRWSAAVPPLHKGDAVTKLLVGAIAGGMLACAAILG
DGIASADTALIVPGTAPSPYGPLRSLYHFNPAMQPQIGANYYNPTATRHVVSYPGSFWPV
TGLNSPTVGSSVSAGTNNLDAAIRSTDGPIFVAGLSQGTLVLDREQARLANDPTAPPPGQ
LTFIKAGDPNNLLWRAFRPGTHVPIIDYTVPAPAESQYDTINIVGQYDIFSDPPNRPGNL
LADLNAIAAGGYYGHSATAFSDPARVAPRDITTTTNSLGATTTTYFIRTDQLPLVRALVD
MAGLPPQAAGTVDAALRPIIDRAYQPGPAPAVNPRDLVQGIRGIPAIAPAIAIPIGSTTG
ASAATSTAAATAAATNALRGANVGPGANKALSMVRGLLPKGKKH*

Genomic Sequence

>Rv3822
ATGAAATGTCCAGGCGTCTCCGACTGCGTTGCGACCGTAAGGCACGATAACGTGTTTGCT
ATTGCTGCTGGTTTGCGTTGGTCGGCCGCTGTACCGCCGCTACACAAAGGGGACGCTGTG
ACCAAACTGCTCGTCGGGGCCATCGCGGGCGGAATGCTAGCTTGCGCAGCTATATTGGGC
GACGGAATCGCTTCGGCCGATACTGCGTTGATAGTACCCGGTACCGCACCGTCCCCGTAC
GGGCCACTCAGGTCGCTCTATCATTTCAATCCCGCGATGCAGCCTCAGATCGGCGCGAAT
TACTACAACCCCACCGCTACCCGCCACGTCGTTTCATATCCAGGCAGCTTTTGGCCTGTC
ACAGGCTTGAATTCGCCCACCGTCGGCAGTTCTGTCAGTGCCGGGACGAACAATCTCGAT
GCGGCGATCCGCAGCACTGACGGACCAATCTTCGTGGCCGGGTTATCACAGGGCACGCTC
GTGCTTGACCGCGAGCAGGCACGGTTAGCGAATGACCCGACGGCTCCTCCCCCTGGGCAA
CTCACATTCATCAAGGCCGGCGACCCTAACAATCTTCTTTGGCGGGCGTTTAGGCCGGGA
ACCCACGTGCCGATCATCGACTACACCGTTCCGGCCCCAGCGGAAAGCCAGTACGACACA
ATCAATATCGTGGGCCAGTACGACATTTTTTCTGACCCGCCTAATCGTCCGGGCAACCTA
CTCGCTGACCTCAATGCGATTGCCGCGGGCGGATACTACGGCCACAGCGCCACCGCATTC
TCGGACCCAGCTCGCGTTGCGCCTAGGGACATTACGACGACAACGAACAGTTTGGGTGCG
ACGACCACGACCTACTTCATCCGGACCGATCAGCTACCTCTGGTGCGGGCGCTGGTGGAC
ATGGCGGGCCTGCCCCCGCAGGCGGCGGGAACAGTTGATGCCGCACTGCGGCCCATAATT
GACAGGGCTTATCAGCCCGGACCAGCACCCGCTGTGAACCCGCGTGATTTGGTCCAGGGC
ATCCGCGGTATCCCCGCCATCGCCCCTGCCATCGCCATCCCTATCGGCAGCACCACCGGG
GCCAGTGCCGCCACCAGCACCGCTGCCGCCACGGCAGCAGCAACAAATGCGCTCCGCGGG
GCCAACGTGGGCCCGGGCGCCAACAAGGCGTTGTCGATGGTCCGGGGTTTGCTACCCAAA
GGGAAGAAGCACTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Transcription Rv0757	active	sourish10	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Transcription Rv0757	active	sourish10	2012-10-05
	Co-expression (Functional linkage) authors,S. Adindla,L. Guruprasad Sequence analysis corresponding to the PPE and PE proteins in Mycobacterium tuberculosis and other genomes. J. Biosci. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
Name	Membrane-associated acyltransferase responsible for the synthesis of the tri- and tetra-acylated forms of sulfolipids	active	mjackson	2012-10-05
	Polymethyl-branched acyltrehaloses
Symbol	chp1	active	mjackson	2012-10-05
	Polymethyl-branched acyltrehaloses
Name	Membrane-associated acyltransferase responsible for the synthesis of the tri- and tetra-acylated forms of sulfolipids	active	mjackson	2012-10-05
	Polymethyl-branched acyltrehaloses
Symbol	chp1	active	mjackson	2012-10-05
	Polymethyl-branched acyltrehaloses
Other	TBPWY:Polymethyl-branched acyltrehaloses	active	mjackson	2012-03-05
	Membrane-associated acyltransferase responsible for the synthesis of the tri- and tetra-acylated forms of sulfolipids (phenotypic [mycobacterial recombinant strains]; enzymatic) authors,JC. Seeliger,CM. Holsclaw,MW. Schelle,Z. Botyanszki,SA. Gilmore,SE. Tully,M. Niederweis,BF. Cravatt,JA. Leary,CR. Bertozzi Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis. The Journal of biological chemistry 2011
Symbol	chp1	active	mjackson	2012-03-05
	Membrane-associated acyltransferase responsible for the synthesis of the tri- and tetra-acylated forms of sulfolipids (phenotypic [mycobacterial recombinant strains]; enzymatic) authors,JC. Seeliger,CM. Holsclaw,MW. Schelle,Z. Botyanszki,SA. Gilmore,SE. Tully,M. Niederweis,BF. Cravatt,JA. Leary,CR. Bertozzi Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis. The Journal of biological chemistry 2011