Rv3824c - polyketide synthase associated protein papA1
Protein Domains

Gene Information
LocusRv3824c
SymbolpapA1
Gene Namepolyketide synthase associated protein papA1
Location4291639 - 4293174 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1536 bp
Protein:512 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number19830
Related GenesMAP3721 MAP3763c MAV_2005 MAV_4883 Mkms_3178 Mmcs_3118 MSMEG_4728 MT3928 MT3932 nfa30230 Rv3820c
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
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Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionTranscription Rv0757activesourish102012-10-05
Co-expression (Functional linkage)
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
InteractionTranscription Rv0757activesourish102012-10-05
Co-expression (Functional linkage)
authors,S. Adindla,L. Guruprasad Sequence analysis corresponding to the PPE and PE proteins in Mycobacterium tuberculosis and other genomes. J. Biosci. 2003
InteractionOperon Rv3825cactivesourish102012-10-05
Structural Analysis
P. Kumar, MW. Schelle et al. PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc. Natl. Acad. Sci. U.S.A. 2007
InteractionOperon Rv3825cactivesourish102012-10-05
Spectrophotometric
P. Kumar, MW. Schelle et al. PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc. Natl. Acad. Sci. U.S.A. 2007
InteractionRegulatedBy Rv0348activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
InteractionRegulatedBy Rv0757activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
InteractionRegulatedBy Rv1221activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
NameAcyltransferase responsible for the transfer of (hydroxy-)phthioceranic acids to the 3'-position of trehalose-2-sulfate-2'-palmitate to form a diacylated precursor of sulfolipid-Iactivemjackson2012-10-05
Polymethyl-branched acyltrehaloses
NameAcyltransferase responsible for the transfer of (hydroxy-)phthioceranic acids to the 3'-position of trehalose-2-sulfate-2'-palmitate to form a diacylated precursor of sulfolipid-Iactivemjackson2012-10-05
Polymethyl-branched acyltrehaloses
OtherTBPWY:Polymethyl-branched acyltrehalosesactivemjackson2012-03-05
Acyltransferase responsible for the transfer of (hydroxy-)phthioceranic acids to the 3'-position of trehalose-2-sulfate-2'-palmitate to form a diacylated precursor of sulfolipid-I (phenotypic [mycobacterial recombinant strains]; enzymatic)
P. Kumar, MW. Schelle et al. PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc. Natl. Acad. Sci. U.S.A. 2007