Rv3869 - conserved membrane protein

Expression: Most Significant Conditions for Rv3869

Protein Domains

Gene Information
Locus	Rv3869
Symbol
Gene Name	conserved membrane protein
Location	4345039 - 4346481 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1443 bp Protein:481 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	19569
Related Genes	Mkms_0074 ML0054 Mmcs_0065 MSMEG_0060 MT3982 Mvan_0073
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3869
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3869 Transcript 1
MGLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSIALGIVVAVLILAGAAL
LAYFKPQGKLGGTSLFTDRATNQLYVLLSGQLHPVYNLTSARLVLGNPANPATVKSSELS
KLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTSPVVQTAVIAMPLEIDASIDP
LQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMGIPVTARPTPISEGMFNALPDMG
PWQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGPQYYVVLPDGIAQVNATTAAALRAT
QAHGLVAPPAMVPSLVVRIAERVYPSPLPDEPLKIVSRPQDPALCWSWQRSAGDQSPQST
VLSGRHLPISPSAMNMGIKQIHGTATVYLDGGKFVALQSPDPRYTESMYYIDPQGVRYGV
PNAETAKSLGLSSPQNAPWEIVRLLVDGPVLSKDAALLEHDTLPADPSPRKVPAGASGAP
*

Genomic Sequence

>Rv3869
ATGGGGCTTCGCCTCACCACCAAGGTTCAGGTTAGCGGCTGGCGTTTTCTGCTGCGCCGG
CTCGAACACGCCATCGTGCGCCGGGACACCCGGATGTTTGACGACCCGCTGCAGTTCTAC
AGCCGCTCGATCGCTCTTGGCATCGTCGTCGCGGTCCTGATTCTGGCGGGTGCCGCGCTG
CTGGCGTACTTCAAACCACAAGGCAAACTCGGCGGCACCAGCCTGTTCACCGACCGCGCG
ACCAACCAGCTTTACGTGCTGCTGTCCGGACAGTTGCATCCGGTCTACAACCTGACTTCG
GCGCGGCTGGTGCTGGGCAATCCGGCCAACCCGGCCACCGTGAAGTCCTCCGAACTGAGC
AAGCTGCCGATGGGCCAGACCGTTGGAATCCCCGGCGCCCCCTACGCCACGCCTGTTTCG
GCGGGCAGCACCTCGATCTGGACCCTATGCGACACCGTCGCCCGAGCCGACTCCACTTCC
CCGGTAGTGCAGACCGCGGTCATCGCGATGCCGTTGGAGATCGATGCTTCGATCGATCCG
CTCCAGTCACACGAAGCGGTGCTGGTGTCCTACCAGGGCGAAACCTGGATCGTCACAACT
AAGGGACGCCACGCCATAGATCTGACCGACCGCGCCCTCACCTCGTCGATGGGGATACCG
GTGACGGCCAGGCCAACCCCGATCTCGGAGGGCATGTTCAACGCGCTGCCTGATATGGGG
CCCTGGCAGCTGCCGCCGATACCGGCGGCGGGCGCGCCCAATTCGCTTGGCCTACCTGAT
GATCTAGTGATCGGATCGGTCTTCCAGATCCACACCGACAAGGGCCCGCAATACTATGTG
GTGCTGCCCGACGGCATCGCGCAGGTCAACGCGACAACCGCTGCGGCGCTGCGCGCCACC
CAGGCGCACGGGCTGGTCGCGCCACCGGCAATGGTGCCCAGTCTGGTCGTCAGAATCGCC
GAACGGGTATACCCCTCACCGCTACCCGATGAACCGCTCAAGATCGTGTCCCGGCCGCAG
GATCCCGCGCTGTGCTGGTCATGGCAACGCAGCGCCGGCGACCAGTCGCCGCAGTCAACG
GTGCTGTCCGGCCGGCATCTGCCGATATCGCCCTCAGCGATGAACATGGGGATCAAGCAG
ATCCACGGGACGGCGACCGTTTACCTCGACGGCGGAAAATTCGTGGCACTGCAATCCCCC
GATCCTCGATACACCGAATCGATGTACTACATCGATCCACAGGGCGTGCGTTATGGGGTG
CCTAACGCGGAGACAGCCAAGTCGCTGGGCCTGAGTTCACCCCAAAACGCGCCCTGGGAG
ATCGTTCGTCTCCTGGTCGACGGTCCGGTGCTGTCGAAAGATGCCGCACTGCTCGAGCAC
GACACGCTGCCCGCTGACCCTAGCCCCCGAAAAGTTCCCGCCGGAGCCTCCGGAGCCCCC
TGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3871	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
Interaction	PhysicalInteraction Rv3871	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3871	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
Interaction	PhysicalInteraction Rv3870	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3870	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) PA. Champion, SA. Stanley et al. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 2006
Interaction	PhysicalInteraction Rv3877	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
Interaction	PhysicalInteraction Rv3871	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
Interaction	PhysicalInteraction Rv3870	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) A. Luthra, A. Mahmood et al. Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis. J. Biol. Chem. 2008
Interaction	PhysicalInteraction Rv3877	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3871	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3870	active	shahanup86	2012-10-05
	Co-expression (Functional linkage) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006