Rv3876 - conserved alanine and proline rich protein

Expression: Most Significant Conditions for Rv3876

Protein Domains

Gene Information
Locus	Rv3876
Symbol
Gene Name	conserved alanine and proline rich protein
Location	4353010 - 4355010 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2001 bp Protein:667 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	27532
Related Genes	MAP0163 MAV_0156 ML0048 MT3990 MT4003 Rv3888c
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3876
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3876 Transcript 1
MAADYDKLFRPHEGMEAPDDMAAQPFFDPSASFPPAPASANLPKPNGQTPPPTSDDLSER
FVSAPPPPPPPPPPPPPTPMPIAAGEPPSPEPAASKPPTPPMPIAGPEPAPPKPPTPPMP
IAGPEPAPPKPPTPPMPIAGPAPTPTESQLAPPRPPTPQTPTGAPQQPESPAPHVPSHGP
HQPRRTAPAPPWAKMPIGEPPPAPSRPSASPAEPPTRPAPQHSRRARRGHRYRTDTERNV
GKVATGPSIQARLRAEEASGAQLAPGTEPSPAPLGQPRSYLAPPTRPAPTEPPPSPSPQR
NSGRRAERRVHPDLAAQHAAAQPDSITAATTGGRRRKRAAPDLDATQKSLRPAAKGPKVK
KVKPQKPKATKPPKVVSQRGWRHWVHALTRINLGLSPDEKYELDLHARVRRNPRGSYQIA
VVGLKGGAGKTTLTAALGSTLAQVRADRILALDADPGAGNLADRVGRQSGATIADVLAEK
ELSHYNDIRAHTSVNAVNLEVLPAPEYSSAQRALSDADWHFIADPASRFYNLVLADCGAG
FFDPLTRGVLSTVSGVVVVASVSIDGAQQASVALDWLRNNGYQDLASRACVVINHIMPGE
PNVAVKDLVRHFEQQVQPGRVVVMPWDRHIAAGTEISLDLLDPIYKRKVLELAAALSDDF
ERAGRR*

Genomic Sequence

>Rv3876
ATGGCGGCCGACTACGACAAGCTCTTCCGGCCGCACGAAGGTATGGAAGCTCCGGACGAT
ATGGCAGCGCAGCCGTTCTTCGACCCCAGTGCTTCGTTTCCGCCGGCGCCCGCATCGGCA
AACCTACCGAAGCCCAACGGCCAGACTCCGCCCCCGACGTCCGACGACCTGTCGGAGCGG
TTCGTGTCGGCCCCGCCGCCGCCACCCCCACCCCCACCTCCGCCTCCGCCAACTCCGATG
CCGATCGCCGCAGGAGAGCCGCCCTCGCCGGAACCGGCCGCATCTAAACCACCCACACCC
CCCATGCCCATCGCCGGACCCGAACCGGCCCCACCCAAACCACCCACACCCCCCATGCCC
ATCGCCGGACCCGAACCGGCCCCACCCAAACCACCCACACCTCCGATGCCCATCGCCGGA
CCTGCACCCACCCCAACCGAATCCCAGTTGGCGCCCCCCAGACCACCGACACCACAAACG
CCAACCGGAGCGCCGCAGCAACCGGAATCACCGGCGCCCCACGTACCCTCGCACGGGCCA
CATCAACCCCGGCGCACCGCACCAGCACCGCCCTGGGCAAAGATGCCAATCGGCGAACCC
CCGCCCGCTCCGTCCAGACCGTCTGCGTCCCCGGCCGAACCACCGACCCGGCCTGCCCCC
CAACACTCCCGACGTGCGCGCCGGGGTCACCGCTATCGCACAGACACCGAACGAAACGTC
GGGAAGGTAGCAACTGGTCCATCCATCCAGGCGCGGCTGCGGGCAGAGGAAGCATCCGGC
GCGCAGCTCGCCCCCGGAACGGAGCCCTCGCCAGCGCCGTTGGGCCAACCGAGATCGTAT
CTGGCTCCGCCCACCCGCCCCGCGCCGACAGAACCTCCCCCCAGCCCCTCGCCGCAGCGC
AACTCCGGTCGGCGTGCCGAGCGACGCGTCCACCCCGATTTAGCCGCCCAACATGCCGCG
GCGCAACCTGATTCAATTACGGCCGCAACCACTGGCGGTCGTCGCCGCAAGCGTGCAGCG
CCGGATCTCGACGCGACACAGAAATCCTTAAGGCCGGCGGCCAAGGGGCCGAAGGTGAAG
AAGGTGAAGCCCCAGAAACCGAAGGCCACGAAGCCGCCCAAAGTGGTGTCGCAGCGCGGC
TGGCGACATTGGGTGCATGCGTTGACGCGAATCAACCTGGGCCTGTCACCCGACGAGAAG
TACGAGCTGGACCTGCACGCTCGAGTCCGCCGCAATCCCCGCGGGTCGTATCAGATCGCC
GTCGTCGGTCTCAAAGGTGGGGCTGGCAAAACCACGCTGACAGCAGCGTTGGGGTCGACG
TTGGCTCAGGTGCGGGCCGACCGGATCCTGGCTCTAGACGCGGATCCAGGCGCCGGAAAC
CTCGCCGATCGGGTAGGGCGACAATCGGGCGCGACCATCGCTGATGTGCTTGCAGAAAAA
GAGCTGTCGCACTACAACGACATCCGCGCACACACTAGCGTCAATGCGGTCAATCTGGAA
GTGCTGCCGGCACCGGAATACAGCTCGGCGCAGCGCGCGCTCAGCGACGCCGACTGGCAT
TTCATCGCCGATCCTGCGTCGAGGTTTTACAACCTCGTCTTGGCTGATTGTGGGGCCGGC
TTCTTCGACCCGCTGACCCGCGGCGTGCTGTCCACGGTGTCCGGTGTCGTGGTCGTGGCA
AGTGTCTCAATCGACGGCGCACAACAGGCGTCGGTCGCGTTGGACTGGTTGCGCAACAAC
GGTTACCAAGATTTGGCGAGCCGCGCATGCGTGGTCATCAATCACATCATGCCGGGAGAA
CCCAATGTCGCAGTTAAAGACCTGGTGCGGCATTTCGAACAGCAAGTTCAACCCGGCCGG
GTCGTGGTCATGCCGTGGGACAGGCACATTGCGGCCGGAACCGAGATTTCACTCGACTTG
CTCGACCCTATCTACAAGCGCAAGGTCCTCGAATTGGCCGCAGCGCTATCCGACGATTTC
GAGAGGGCTGGACGTCGTTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3874	active	sourish10	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3874	active	sourish10	2012-10-05
	Affinity purification (Physical interaction) B. Callahan, K. Nguyen et al. Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA. J. Bacteriol. 2010
Interaction	PhysicalInteraction Rv3864	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,M. Sani,EN. Houben,J. Geurtsen,J. Pierson,K. de Punder,M. van Zon,B. Wever,SR. Piersma,CR. Jiménez,M. Daffé,BJ. Appelmelk,W. Bitter,N. van der Wel,PJ. Peters Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 2010
Interaction	PhysicalInteraction Rv3864	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3864	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, K. Eiglmeier et al. Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect. Immun. 2002
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006