Rv3879c - hypothetical alanine and proline rich protein

Expression: Most Significant Conditions for Rv3879c

Protein Domains

Gene Information
Locus	Rv3879c
Symbol
Gene Name	hypothetical alanine and proline rich protein
Location	4357593 - 4359782 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2190 bp Protein:730 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	28266
Related Genes	MAP3998c MAV_4644 MT3993 MT4022 Rv3903c
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3879c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3879c Transcript 1
MSITRPTGSYARQMLDPGGWVEADEDTFYDRAQEYSQVLQRVTDVLDTCRQQKGHVFEGG
LWSGGAANAANGALGANINQLMTLQDYLATVITWHRHIAGLIEQAKSDIGNNVDGAQREI
DILENDPSLDADERHTAINSLVTATHGANVSLVAETAERVLESKNWKPPKNALEDLLQQK
SPPPPDVPTLVVPSPGTPGTPGTPITPGTPITPGTPITPIPGAPVTPITPTPGTPVTPVT
PGKPVTPVTPVKPGTPGEPTPITPVTPPVAPATPATPATPVTPAPAPHPQPAPAPAPSPG
PQPVTPATPGPSGPATPGTPGGEPAPHVKPAALAEQPGVPGQHAGGGTQSGPAHADESAA
SVTPAAASGVPGARAAAAAPSGTAVGAGARSSVGTAAASGAGSHAATGRAPVATSDKAAA
PSTRAASARTAPPARPPSTDHIDKPDRSESADDGTPVSMIPVSAARAARDAATAAASARQ
RGRGDALRLARRIAAALNASDNNAGDYGFFWITAVTTDGSIVVANSYGLAYIPDGMELPN
KVYLASADHAIPVDEIARCATYPVLAVQAWAAFHDMTLRAVIGTAEQLASSDPGVAKIVL
EPDDIPESGKMTGRSRLEVVDPSAAAQLADTTDQRLLDLLPPAPVDVNPPGDERHMLWFE
LMKPMTSTATGREAAHLRAFRAYAAHSQEIALHQAHTATDAAVQRVAVADWLYWQYVTGL
LDRALAAAC*

Genomic Sequence

>Rv3879c
ATGAGTATTACCAGGCCGACGGGCAGCTATGCCAGACAGATGCTGGATCCGGGCGGCTGG
GTGGAAGCCGATGAAGACACTTTCTATGACCGGGCCCAGGAATATAGCCAGGTTTTGCAA
AGGGTCACCGATGTATTGGACACCTGCCGCCAGCAGAAAGGCCACGTCTTCGAAGGCGGC
CTATGGTCCGGCGGCGCCGCCAATGCTGCCAACGGCGCCCTGGGTGCAAACATCAATCAA
TTGATGACGCTGCAGGATTATCTCGCCACGGTGATTACCTGGCACAGGCATATTGCCGGG
TTGATTGAGCAAGCTAAATCCGATATCGGCAATAATGTGGATGGCGCTCAACGGGAGATC
GATATCCTGGAGAATGACCCTAGCCTGGATGCTGATGAGCGCCATACCGCCATCAATTCA
TTGGTCACGGCGACGCATGGGGCCAATGTCAGTCTGGTCGCCGAGACCGCTGAGCGGGTG
CTGGAATCCAAGAATTGGAAACCTCCGAAGAACGCACTCGAGGATTTGCTTCAGCAGAAG
TCGCCGCCACCCCCAGACGTGCCTACCCTGGTCGTGCCATCCCCGGGCACACCGGGCACA
CCGGGAACCCCGATCACCCCGGGAACCCCGATCACCCCGGGAACCCCAATCACACCCATC
CCGGGAGCGCCGGTAACTCCGATCACACCAACGCCCGGCACTCCCGTCACGCCGGTGACC
CCGGGCAAGCCGGTCACCCCGGTGACCCCGGTCAAACCGGGCACACCAGGCGAGCCAACC
CCGATCACGCCGGTCACCCCCCCGGTCGCCCCGGCCACACCGGCAACCCCGGCCACGCCC
GTTACCCCAGCTCCCGCTCCACACCCGCAGCCGGCTCCGGCACCGGCGCCATCGCCTGGG
CCCCAGCCGGTTACACCGGCCACTCCCGGTCCGTCTGGTCCAGCAACACCGGGCACCCCA
GGGGGCGAGCCGGCGCCGCACGTCAAACCCGCGGCGTTGGCGGAGCAACCTGGTGTGCCG
GGCCAGCATGCGGGCGGGGGGACGCAGTCGGGGCCTGCCCATGCGGACGAATCCGCCGCG
TCGGTGACGCCGGCTGCGGCGTCCGGTGTCCCGGGCGCACGGGCGGCGGCCGCCGCGCCG
AGCGGTACCGCCGTGGGAGCGGGCGCGCGTTCGAGCGTGGGTACGGCCGCGGCCTCGGGC
GCGGGGTCGCATGCTGCCACTGGGCGGGCGCCGGTGGCTACCTCGGACAAGGCGGCGGCA
CCGAGCACGCGGGCGGCCTCGGCGCGGACGGCACCTCCTGCCCGCCCGCCGTCGACCGAT
CACATCGACAAACCCGATCGCAGCGAGTCTGCAGATGACGGTACGCCGGTGTCGATGATC
CCGGTGTCGGCGGCTCGGGCGGCACGCGACGCCGCCACTGCAGCTGCCAGCGCCCGCCAG
CGTGGCCGCGGTGATGCGCTGCGGTTGGCGCGACGCATCGCGGCGGCGCTCAACGCGTCC
GACAACAACGCGGGCGACTACGGGTTCTTCTGGATCACCGCGGTGACCACCGACGGTTCC
ATCGTCGTGGCCAACAGCTATGGGCTGGCCTACATACCCGACGGGATGGAATTGCCGAAT
AAGGTGTACTTGGCCAGCGCGGATCACGCAATCCCGGTTGACGAAATTGCACGCTGTGCC
ACCTACCCGGTTTTGGCCGTGCAAGCCTGGGCGGCTTTCCACGACATGACGCTGCGGGCG
GTGATCGGTACCGCGGAGCAGTTGGCCAGTTCGGATCCCGGTGTGGCCAAGATTGTGCTG
GAGCCAGATGACATTCCGGAGAGCGGCAAAATGACGGGCCGGTCGCGGCTGGAGGTCGTC
GACCCCTCGGCGGCGGCTCAGCTGGCCGACACTACCGATCAGCGTTTGCTCGACTTGTTG
CCGCCGGCGCCGGTGGATGTCAATCCACCGGGCGATGAGCGGCACATGCTGTGGTTCGAG
CTGATGAAGCCCATGACCAGCACCGCTACCGGCCGCGAGGCCGCTCATCTGCGGGCGTTC
CGGGCCTACGCTGCCCACTCACAGGAGATTGCCCTGCACCAAGCGCACACTGCGACTGAC
GCGGCCGTCCAGCGTGTGGCCGTCGCGGACTGGCTGTACTGGCAATACGTCACCGGGTTG
CTCGACCGGGCCCTGGCCGCCGCATGCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv3864	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) authors,M. Sani,EN. Houben,J. Geurtsen,J. Pierson,K. de Punder,M. van Zon,B. Wever,SR. Piersma,CR. Jiménez,M. Daffé,BJ. Appelmelk,W. Bitter,N. van der Wel,PJ. Peters Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 2010
Interaction	PhysicalInteraction Rv3864	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, L. Majlessi et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 2006
Interaction	PhysicalInteraction Rv3864	active	shahanup86	2012-10-05
	Affinity purification (Physical interaction) P. Brodin, K. Eiglmeier et al. Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect. Immun. 2002
Interaction	Transcription Rv3676	active	jgalag	2012-10-05
	Band shift M. Stapleton, I. Haq et al. Mycobacterium tuberculosis cAMP receptor protein (Rv3676) differs from the Escherichia coli paradigm in its cAMP binding and DNA binding properties and transcription activation properties. J. Biol. Chem. 2010
Interaction	Transcription Rv3676	active	jgalag	2012-10-05
	Band shift G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	RegulatedBy Rv3676	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008