Rv1184c - hypothetical exported protein

Expression: Most Significant Conditions for Rv1184c

Protein Domains

Gene Information
Locus	Rv1184c
Symbol
Gene Name	hypothetical exported protein
Location	1324532 - 1325611 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1080 bp Protein:360 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	12705
Related Genes	MAP2234 MAV_1760 ML1232 MT1221 MT3643 Rv3539
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1184c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1184c Transcript 1
MKRVIAGAFAVWLVGWAGGFGTAIAASEPAYPWAPGPPPSPSPVGDASTAKVVYALGGAR
MPGIPWYEYTNQAGSQYFPNAKHDLIDYPAGAAFSWWPTMLLPPGSHQDNMTVGVAVKDG
TNSLDNAIHHGTDPAAAVGLSQGSLVLDQEQARLANDPTAPAPDKLQFTTFGDPTGRHAF
GASFLARIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVVTAYDGFSDFPDRPDNLLAVANA
AIGAAIAHTPIGFTGPGDVPPQNIRTTVNSRGATTTTYLVPVNHLPLTLPLRYLGMSDAE
VDQIDSVLQPQIDAAYARNDNWFTRPVSVDPVRGLDPLTAPGSIVEGARGLLGSPAFGG*

Genomic Sequence

>Rv1184c
ATGAAGCGAGTGATTGCGGGAGCATTCGCGGTCTGGCTCGTGGGTTGGGCCGGTGGATTC
GGAACCGCTATTGCGGCAAGCGAACCCGCGTACCCGTGGGCTCCTGGGCCACCTCCGTCC
CCCTCTCCGGTGGGCGACGCTTCAACCGCCAAAGTCGTCTACGCCCTCGGGGGCGCGCGA
ATGCCGGGCATTCCCTGGTACGAGTACACGAACCAGGCTGGCTCTCAATATTTCCCAAAC
GCAAAGCACGATCTCATCGACTATCCCGCCGGAGCGGCCTTCAGCTGGTGGCCCACCATG
CTTTTGCCGCCAGGGAGCCACCAAGACAACATGACGGTGGGCGTGGCGGTCAAAGATGGG
ACAAACAGCCTTGATAACGCAATTCATCACGGAACCGATCCAGCCGCGGCCGTCGGCCTA
TCCCAGGGTTCCCTCGTGCTCGACCAGGAGCAGGCGCGGCTCGCCAACGACCCGACGGCA
CCTGCACCGGACAAGCTGCAGTTCACGACGTTCGGCGACCCCACCGGACGTCATGCGTTC
GGAGCGAGCTTCCTGGCCCGAATTTTTCCCCCCGGTAGCCACATTCCGATTCCCTTCATC
GAATATACGATGCCCCAGCAGGTGGATAGCCAGTACGACACCAACCATGTCGTCACCGCA
TACGACGGCTTCAGCGACTTCCCGGACCGGCCGGACAATCTGTTAGCGGTCGCCAATGCG
GCCATCGGCGCTGCCATCGCGCACACCCCAATCGGGTTCACCGGACCCGGTGACGTACCC
CCGCAGAACATCAGGACCACCGTCAACTCACGAGGCGCTACCACGACGACGTATCTGGTC
CCCGTGAACCACCTCCCGTTGACCTTGCCGCTGCGTTACCTCGGCATGTCCGACGCCGAA
GTCGATCAAATCGACAGTGTGCTGCAACCACAGATCGACGCGGCCTATGCACGCAACGAC
AATTGGTTCACCCGGCCGGTCTCCGTGGATCCGGTGCGAGGCCTGGATCCGCTGACCGCT
CCGGGCTCGATCGTGGAAGGTGCCCGCGGCTTACTGGGCTCCCCCGCCTTCGGCGGCTAA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv0348	active	akankshajain.21	2012-10-05
	B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) ML. Chesne-Seck, N. Barilone et al. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) authors,A. Sola-Landa,RS. Moura,JF. Martín The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. U.S.A. 2003
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, CY. Soto et al. The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) A. Sinha, S. Gupta et al. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. J. Bacteriol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) M. Ryndak, S. Wang et al. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol. 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) JA. Asensio, A. Arbués et al. Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials. Expert opinion on biological therapy 2008
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Interaction	Regulatory Rv0757	active	singhpankaj2116	2012-10-05
	Co-expression (Functional linkage) J. Gonzalo-Asensio, S. Mostowy et al. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS ONE 2008
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. J. Gonzalo Asensio, C. Maia et al. The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 2006
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006