Rv2222c - glutamine synthetase glnA2

Expression: Most Significant Conditions for Rv2222c

Protein Domains

Gene Information
Locus	Rv2222c
Symbol	glnA2
Gene Name	glutamine synthetase glnA2
Location	2492402 - 2493742 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1341 bp Protein:447 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	34632
Related Genes	Acel_0919 CE2127 cg2447 DIP1671 jk0675 MAP1962 MAP1966c MAV_2244 MAV_2267 Mkms_3382 Mkms_3390 ML1631 Mmcs_3320 Mmcs_3328 MSMEG_4290 MSMEG_4294 MT2278 MT2280 MUL_1335 MUL_1340 Mvan_3585 Mvan_3598 nfa16600 PPA0664 PPA0671 Rv2220 SAV5954
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2222c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2222c Transcript 1
MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAFEEGIGFDGSSIEGFA
RVSESDTVAHPDPSTFQVLPWATSSGHHHSARMFCDITMPDGSPSWADPRHVLRRQLTKA
GELGFSCYVHPEIEFFLLKPGPEDGSVPVPVDNAGYFDQAVHDSALNFRRHAIDALEFMG
ISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYVIKEVALEEGARASFMPKPFGQHP
GSAMHTHMSLFEGDVNAFHSADDPLQLSEVGKSFIAGILEHACEISAVTNQWVNSYKRLV
QGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRVEVRSPDSACNPYLTFAVLLAAGLRG
VEKGYVLGPQAEDNVWDLTPEERRAMGYRELPSSLDSALRAMEASELVAEALGEHVFDFF
LRNKRTEWANYRSHVTPYELRTYLSL*

Genomic Sequence

>Rv2222c
ATGGACCGACAGAAGGAATTCGTTCTTCGTACCCTGGAAGAACGCGACATCCGCTTCGTC
CGGCTGTGGTTCACAGACGTGCTCGGTTTCCTCAAGTCGGTCGCCATCGCCCCAGCCGAA
CTCGAGGGCGCCTTCGAGGAAGGCATCGGCTTCGACGGATCCTCGATCGAGGGCTTTGCG
CGGGTCTCGGAATCCGATACGGTGGCGCACCCGGACCCGTCGACCTTCCAGGTGCTGCCC
TGGGCCACCAGTTCCGGCCACCACCACTCAGCGCGGATGTTTTGCGACATCACCATGCCG
GACGGCTCGCCGTCGTGGGCGGACCCGCGGCACGTGTTGCGGCGGCAGCTGACGAAGGCC
GGCGAACTCGGCTTCTCCTGCTACGTGCATCCCGAAATCGAGTTCTTCCTGCTCAAGCCC
GGACCCGAGGACGGGTCGGTGCCCGTCCCGGTCGACAACGCCGGCTATTTCGACCAAGCG
GTGCACGACTCCGCCTTGAACTTTCGCCGCCACGCGATCGATGCCCTGGAATTCATGGGC
ATCTCGGTGGAGTTCAGCCATCACGAAGGCGCACCCGGCCAGCAGGAGATCGACCTGCGG
TTTGCCGACGCTCTGTCGATGGCTGACAACGTGATGACCTTCCGCTACGTCATCAAAGAA
GTCGCGCTGGAAGAGGGCGCCCGGGCGTCGTTCATGCCCAAGCCATTCGGCCAGCACCCG
GGCTCGGCGATGCACACCCACATGAGCCTGTTCGAGGGTGATGTCAACGCGTTCCACAGC
GCTGATGATCCGCTGCAGCTGTCGGAAGTGGGTAAATCGTTCATCGCCGGGATCCTGGAG
CACGCTTGCGAGATCAGCGCGGTCACAAATCAGTGGGTCAACTCTTACAAGCGGCTGGTG
CAGGGCGGCGAAGCGCCCACGGCCGCGTCGTGGGGGGCCGCCAACCGATCCGCCCTAGTG
CGGGTGCCGATGTACACGCCGCACAAGACCTCGTCGCGGCGGGTCGAAGTACGCAGCCCT
GATTCGGCGTGCAATCCCTATCTGACATTCGCCGTGCTGCTGGCCGCGGGATTGCGGGGT
GTAGAGAAGGGTTACGTGCTGGGCCCGCAGGCCGAGGACAACGTATGGGACCTCACACCC
GAGGAACGCCGAGCGATGGGGTACCGAGAATTGCCGTCCAGTTTGGATAGTGCGCTGCGC
GCCATGGAGGCCTCCGAACTCGTCGCGGAGGCCTTGGGGGAGCACGTTTTTGACTTTTTC
TTGCGCAACAAGCGCACGGAGTGGGCGAACTACCGCAGCCACGTCACGCCATACGAGCTG
CGCACCTACCTGTCGCTGTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Structural Analysis GS. Hotter, P. Mouat et al. Independent transcription of glutamine synthetase (glnA2) and glutamine synthetase adenylyltransferase (glnE) in Mycobacterium bovis and Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland) 2008
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Structural Analysis authors,WW. Krajewski,TA. Jones,SL. Mowbray Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights. Proc. Natl. Acad. Sci. U.S.A. 2005
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Structural Analysis R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Spectrophotometric GS. Hotter, P. Mouat et al. Independent transcription of glutamine synthetase (glnA2) and glutamine synthetase adenylyltransferase (glnE) in Mycobacterium bovis and Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland) 2008
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Spectrophotometric authors,WW. Krajewski,TA. Jones,SL. Mowbray Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights. Proc. Natl. Acad. Sci. U.S.A. 2005
Interaction	Transcription Rv2220	active	jgalag	2012-10-05
	Spectrophotometric R. Manganelli, MI. Voskuil et al. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001