Rv2460c - ATP-dependent clp protease proteolytic subunit 2 clpP2

Expression: Most Significant Conditions for Rv2460c

Protein Domains

Gene Information
Locus	Rv2460c
Symbol	clpP2
Gene Name	ATP-dependent clp protease proteolytic subunit 2 clpP2
Location	2762531 - 2763175 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:645 bp Protein:215 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	34711
Related Genes	CE2311 CE2312 cg2644 DIP1791 DIP1792 jk0544 jk0545 MAP2280c MAP2281c MAV_1713 MAV_1714 Mkms_3650 Mkms_3651 ML1479 Mmcs_3577 Mmcs_3578 MSMEG_4672 MSMEG_4673 MT2535 MT2536 MUL_3730 MUL_3731 Mvan_4039 Mvan_4040 nfa13330 nfa13340 Rv2461c
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2460c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2460c Transcript 1
MNSQNSQIQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQL
LVLESLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGT
PGKRMALPNARVLIHQPSLSGVIQGQFSDLEIQAAEIERMRTLMETTLARHTGKDAGVIR
KDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTA*

Genomic Sequence

>Rv2460c
GTGAATTCCCAAAATTCTCAGATCCAGCCCCAGGCGCGCTACATCCTGCCGTCGTTCATC
GAGCACTCCAGCTTCGGGGTCAAGGAGTCCAATCCATACAACAAGCTGTTCGAGGAACGC
ATCATCTTCCTCGGCGTCCAGGTCGACGACGCGTCGGCGAACGACATCATGGCACAGTTG
CTGGTGTTGGAGTCGTTGGATCCCGACCGCGATATCACCATGTACATCAACTCGCCGGGC
GGTGGGTTCACCTCGCTGATGGCGATCTACGACACCATGCAATACGTGCGGGCCGATATC
CAGACGGTGTGTCTGGGCCAGGCCGCCTCGGCGGCTGCGGTGCTGCTGGCCGCCGGAACA
CCGGGCAAGCGCATGGCGCTGCCGAATGCGCGGGTGTTGATCCATCAGCCGTCGTTGTCG
GGCGTGATCCAGGGACAGTTCTCCGATCTGGAGATCCAGGCCGCCGAGATCGAGCGGATG
CGCACCCTGATGGAAACCACGCTGGCCCGCCACACCGGCAAGGACGCCGGAGTGATCCGC
AAAGACACTGACCGGGACAAGATCTTGACCGCGGAAGAGGCTAAGGACTACGGCATCATC
GACACGGTGCTCGAGTACCGGAAGCTCTCCGCGCAAACCGCCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	PhysicalInteraction Rv2461c	active	akankshajain.21	2012-10-05
	Structural analysis authors,A. Gribun,MS. Kimber,R. Ching,R. Sprangers,KM. Fiebig,WA. Houry The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv2461c	active	akankshajain.21	2012-10-05
	Structural analysis H. Ingvarsson, MJ. Maté et al. Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1. Acta Crystallogr. D Biol. Crystallogr. 2007
Interaction	PhysicalInteraction Rv2461c	active	akankshajain.21	2012-10-05
	Structural analysis AK. Gupta, VM. Katoch et al. Microarray analysis of efflux pump genes in multidrug-resistant Mycobacterium tuberculosis during stress induced by common anti-tuberculous drugs. Microb. Drug Resist. 2010
Interaction	Regulatory Rv2475c	active	akankshajain.21	2012-10-05
	Co-expression (Functional linkage) authors,M. Estorninho,H. Smith,J. Thole,J. Harders-Westerveen,A. Kierzek,RE. Butler,O. Neyrolles,GR. Stewart ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage. Microbiology (Reading, Engl.) 2010
Interaction	PhysicalInteraction Rv2457c	active	akankshajain.21	2012-10-05
	Structural analysis authors,A. Gribun,MS. Kimber,R. Ching,R. Sprangers,KM. Fiebig,WA. Houry The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv2461c	active	akankshajain.21	2012-10-05
	Structural analysis authors,A. Gribun,MS. Kimber,R. Ching,R. Sprangers,KM. Fiebig,WA. Houry The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv2457c	active	akankshajain.21	2012-10-05
	Structural analysis AK. Gupta, VM. Katoch et al. Microarray analysis of efflux pump genes in multidrug-resistant Mycobacterium tuberculosis during stress induced by common anti-tuberculous drugs. Microb. Drug Resist. 2010
Interaction	PhysicalInteraction Rv2461c	active	akankshajain.21	2012-10-05
	Structural analysis AK. Gupta, VM. Katoch et al. Microarray analysis of efflux pump genes in multidrug-resistant Mycobacterium tuberculosis during stress induced by common anti-tuberculous drugs. Microb. Drug Resist. 2010
Interaction	PhysicalInteraction Rv2457c	active	vmevada102	2012-10-05
	Structural analysis authors,A. Gribun,MS. Kimber,R. Ching,R. Sprangers,KM. Fiebig,WA. Houry The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv2457c	active	vmevada102	2012-10-05
	Structural analysis AK. Gupta, VM. Katoch et al. Microarray analysis of efflux pump genes in multidrug-resistant Mycobacterium tuberculosis during stress induced by common anti-tuberculous drugs. Microb. Drug Resist. 2010