Rv2495c - dihydrolipoamide S-acetyltransferase E2 component pdhC
Protein Domains

Gene Information
LocusRv2495c
SymbolpdhC
Gene Namedihydrolipoamide S-acetyltransferase E2 component pdhC
Location2808758 - 2809939 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1182 bp
Protein:394 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number29390
Related GenesAcel_0588 MAP2307c MAV_1677 Mkms_3697 Mmcs_3624 MSMEG_4710 MT2570 MUL_3773 Mvan_4084 SAV4364
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv2495c
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionOperon Rv2497cactiveakankshajain.212012-10-05
Coexpression
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
InteractionOperon Rv2496cactiveakankshajain.212012-10-05
Coexpression
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
InteractionOperon Rv2497cactiveakankshajain.212012-10-05
Coexpression
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
InteractionOperon Rv2496cactiveakankshajain.212012-10-05
Coexpression
J. Tian, R. Bryk et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 2005
InteractionRegulatedBy Rv0348activeyamir.moreno2012-10-05
Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
TermEC:2.3.1.12 Dihydrolipoyllysine-residue acetyltransferase. - NRactiveextern:JZUCKER2012-03-06
Inferred from mutant phenotype
authors,A. Venugopal,R. Bryk,S. Shi,K. Rhee,P. Rath,D. Schnappinger,S. Ehrt,C. Nathan Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host Microbe 2011
TermEC:2.3.1.168 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase. - NRactiveextern:JZUCKER2012-03-06
Inferred from mutant phenotype
authors,A. Venugopal,R. Bryk,S. Shi,K. Rhee,P. Rath,D. Schnappinger,S. Ehrt,C. Nathan Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host Microbe 2011
TermEC:2.3.1.12 Dihydrolipoyllysine-residue acetyltransferase. - NRactiveextern:JZUCKER2012-03-06
Traceable author statement to experimental support
authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
TermEC:2.3.1.168 Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase. - NRactiveextern:JZUCKER2012-03-06
Traceable author statement to experimental support
authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011