Rv3515c - fatty-acid-CoA ligase fadD19

Expression: Most Significant Conditions for Rv3515c

Protein Domains

Gene Information
Locus	Rv3515c
Symbol	fadD19
Gene Name	fatty-acid-CoA ligase fadD19
Location	3950824 - 3952470 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1647 bp Protein:549 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	29688
Related Genes	MAP0550 MAV_0644 Mkms_4715 Mmcs_4627 MSMEG_5914 MT3616 MUL_4075 Mvan_5215 nfa5290
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv3515c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv3515c Transcript 1
MAVALNIADLAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKDDKVGL
YCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRYLFDNSDMVALVHERRYADRVANVL
PDTPHVRTILVVEDGSDQDYRRYGGVEFYSAIAAGSPERDFGERSADAIYLLYTGGTTGF
PKGVMWRHEDIYRVLFGGTDFATGEFVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSAT
WMALFSGQTTVLAPEFNADEVWRTIHKHKVNLLFFTGDAMARPLVDALVKGNDYDLSSLF
LLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSVVAAGQAHGGGPRVRIDHR
TVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEKKTAETFRTINGVRYAIPGDYAQVE
EDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQA
RPGCRPSLAELDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVH
AGHVTSGG*

Genomic Sequence

>Rv3515c
GTGGCCGTGGCCCTGAATATTGCCGATCTCGCCGAGCACGCCATCGACGCCGTGCCTGAC
CGTGTCGCCGTTATCTGCGGCGATGAGCAGTTGACCTACGCCCAGCTGGAGGATAAGGCC
AACCGCCTCGCGCACCACCTGATCGATCAAGGCGTGCAAAAGGACGACAAGGTCGGCCTG
TACTGCCGCAACCGCATCGAGATCGTGATCGCGATGCTGGGCATCGTGAAGGCGGGCGCC
ATCTTGGTGAACGTCAACTTCCGTTACGTGGAGGGCGAACTTCGCTACCTGTTCGACAAC
TCCGACATGGTCGCGTTGGTGCACGAACGCCGCTACGCCGACCGGGTCGCCAACGTTCTC
CCCGACACGCCCCATGTAAGGACGATCTTGGTCGTCGAGGACGGCTCGGACCAGGACTAT
CGGCGCTACGGCGGCGTCGAGTTCTATTCCGCGATCGCGGCGGGCTCGCCGGAGCGTGAC
TTCGGCGAACGCAGCGCCGACGCCATCTATCTGCTCTACACCGGCGGCACCACCGGTTTC
CCCAAGGGTGTGATGTGGCGTCACGAGGACATCTATCGTGTGCTGTTCGGTGGAACCGAC
TTTGCGACAGGAGAGTTCGTCAAAGACGAATACGACCTGGCCAAGGCGGCCGCGGCGAAT
CCACCGATGATCCGCTACCCGATCCCGCCGATGATCCACGGCGCCACCCAGTCGGCCACC
TGGATGGCGCTCTTCTCGGGCCAAACCACGGTACTGGCACCGGAATTCAACGCCGACGAG
GTGTGGCGCACGATCCACAAACACAAGGTGAACCTGCTGTTCTTCACCGGTGATGCGATG
GCCCGCCCGCTGGTCGACGCGCTGGTCAAGGGCAACGACTACGACCTGTCGTCGTTGTTC
CTGTTGGCCAGCACCGCGGCGCTGTTCTCGCCGAGCATCAAGGAGAAACTCCTTGAGCTG
CTGCCGAATCGGGTGATCACGGACTCAATTGGCTCGTCGGAGACGGGTTTTGGCGGTACC
AGCGTCGTTGCTGCCGGGCAGGCGCATGGCGGCGGGCCCCGGGTGCGGATCGACCATCGC
ACCGTCGTGCTCGATGACGACGGCAACGAAGTCAAGCCCGGCTCGGGGATGCGGGGCGTC
ATCGCCAAGAAGGGCAACATTCCCGTCGGCTACTACAAGGACGAGAAGAAGACGGCCGAG
ACGTTCCGGACGATTAACGGTGTGCGCTACGCCATTCCGGGGGACTACGCCCAAGTCGAG
GAGGACGGCACGGTCACCATGCTGGGTCGTGGCTCGGTGTCGATCAACAGCGGCGGCGAG
AAGGTCTACCCCGAAGAGGTCGAGGCCGCTTTGAAGGGGCATCCCGACGTGTTCGACGCT
CTGGTGGTCGGGGTGCCCGATCCGCGTTACGGCCAGCAGGTGGCCGCCGTGGTGCAGGCC
CGGCCGGGTTGTCGGCCGTCGTTGGCCGAGTTGGACTCGTTCGTGCGCTCCGAGATCGCG
GGCTACAAAGTGCCGCGCAGTCTGTGGTTTGTCGACGAGGTGAAGCGTTCGCCCGCCGGT
AAGCCGGACTACCGCTGGGCCAAGGAGCAGACCGAGGCGCGGCCAGCCGATGACGTGCAT
GCGGGACACGTGACGAGCGGTGGGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
Interaction	Regulatory Rv3574	active	priyadarshinipriyanka2001	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	Regulatory Rv3574	active	jgalag	2012-10-05
	Co-expression (Functional linkage) authors,P. Arora,A. Goyal,VT. Natarajan,E. Rajakumara,P. Verma,R. Gupta,M. Yousuf,OA. Trivedi,D. Mohanty,A. Tyagi,R. Sankaranarayanan,RS. Gokhale Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis. Nat. Chem. Biol. 2009
Interaction	Regulatory Rv3574	active	jgalag	2012-10-05
	Co-expression (Functional linkage) SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
Interaction	RegulatedBy Rv3574	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008