Rv0753c - methylmalonate-semialdehyde dehydrogenase mmsA

Expression: Most Significant Conditions for Rv0753c

Protein Domains

Gene Information
Locus	Rv0753c
Symbol	mmsA
Gene Name	methylmalonate-semialdehyde dehydrogenase mmsA
Location	844421 - 845953 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1533 bp Protein:511 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	35285
Related Genes	MAP4215c MAV_2521 MAV_4417 Mkms_1080 Mmcs_1064 MSMEG_1498 MT0777 MUL_0837 Mvan_1362 nfa10370
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv0753c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv0753c Transcript 1
MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA
WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL
KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP
SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA
TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR
ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL
TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE
YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA
IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS*

Genomic Sequence

>Rv0753c
ATGACCACACAGATTTCACATTTCATCGACGGACAACGCACCGCCGGCCAGTCCACGCGC
TCGGCCGACGTCTTCGACCCCAACACCGGCCAGATCCAGGCGAAGGTACCGATGGCCGGC
AAGTCAGACATCGACGCGGCCGTGGCCTCCGCGGTCGAGGCCCAAAAGGGCTGGGCCGCA
TGGAATCCCCAGCGCCGTGCCCGGGTGTTGATGCGGTTTATCGAACTGGTCAACGACACC
ATCGACGAGTTGGCCGAGCTGTTGTCGCGTGAGCACGGCAAAACGCTGGCCGACGCCCGC
GGCGACGTCCAGCGCGGCATCGAGGTAATCGAGTTCTGCCTGGGCATTCCCCACCTGCTC
AAGGGCGAGTACACCGAGGGTGCCGGCCCCGGCATCGACGTCTATTCGCTGCGGCAGCCC
CTGGGTGTGGTCGCGGGGATCACCCCGTTCAACTTCCCGGCGATGATTCCGCTGTGGAAG
GCCGGCCCGGCCCTAGCGTGCGGCAACGCCTTCGTGCTCAAGCCAAGTGAGCGCGACCCG
TCGGTTCCGGTGAGGCTGGCCGAGCTGTTCATCGAGGCGGGCCTGCCGGCGGGCGTGTTC
CAGGTGGTGCACGGCGACAAGGAGGCCGTCGACGCCATCCTGCACCACCCCGACATCAAG
GCCGTCGGCTTCGTCGGCAGCTCGGATATCGCTCAGTACATCTACGCTGGTGCCGCCGCC
ACCGGCAAGCGGGCGCAGTGTTTCGGCGGTGCCAAGAACCACATGATCGTGATGCCCGAC
GCGGACCTGGATCAGGCCGTGGACGCACTGATCGGCGCCGGATACGGCAGCGCCGGCGAA
CGCTGCATGGCGATCAGCGTCGCCGTGCCGGTGGGCGATCAGACCGCGGAGCGGTTGCGC
GCCAGGCTGATCGAGCGGATCAATAACTTGCGGGTGGGACACAGCCTGGACCCCAAGGCG
GACTACGGCCCGCTGGTCACCGGGGCGGCGCTGGCGCGGGTGCGCGACTACATCGGCCAG
GGTGTGGCCGCCGGTGCCGAGCTGGTCGTTGACGGCCGCGACCGCGCCAGCGACGACCTG
ACCTTTGGGCTGCCTGAAGGCGATGCGAACCTGGAGGGCGGCTTCTTCATCGGGCCGACC
CTGTTCGACCATGTCGCTGCCCACATGTCGATCTACACCGACGAAATCTTCGGGCCGGTG
TTGTGCATGGTTCGCGCCCGCGACTACGAAGAGGCGTTGCGGCTGCCGTCGGAGCACGAA
TACGGCAACGGGGTGGCGATCTTCACCCGCGACGGCGACGCGGCCCGCGACTTCGTCTCC
CGGGTGCAGGTGGGCATGGTCGGCGTCAACGTGCCGATCCCGGTGCCGGTGGCCTACCAC
ACTTTCGGCGGCTGGAAGCGCTCCGGCTTCGGCGACCTCAACCAGCACGGCCCGGCGGCA
ATCCAGTTCTACACCAAGGTCAAGACCGTCACGTCGCGATGGCCGTCAGGCATCAAGGAC
GGTGCCGAATTCGTCATCCCCACAATGAGTTAG

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	EC:1.2.1.27 Methylmalonate-semialdehyde dehydrogenase (acylating). - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011
Term	EC:1.2.1.9 Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)). - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011