Rv1106c - cholesterol dehydrogenase
Protein Domains

Gene Information
LocusRv1106c
Symbol
Gene Namecholesterol dehydrogenase
Location1232844 - 1233956 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:1113 bp
Protein:371 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number36092
Related GenesAcel_1936 cg1194 MAP2664 MAP2688 MAV_1225 MAV_1259 Mkms_4185 Mkms_4198 ML0955 ML1942 Mmcs_4109 Mmcs_4123 MSMEG_5228 MT1137 MT1159 MUL_0141 MUL_0172 Mvan_0427 Mvan_4635 nfa26860 PPA2048 Rv1127c
Transcriptional Regulation
Operons View gene in operon browser
Regulatory Network
Search for regulators of Rv1106c
Expression Correlation Genes with Correlated Expression
Scatterplot of Gene Expression

Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
InteractionRegulatory Rv3574activepriyadarshinipriyanka20012012-10-05
Co-expression (Functional linkage)
SL. Kendall,P. Burgess,R. Balhana,M. Withers,A. Ten Bokum,JS. Lott,C. Gao,I. Uhia Castro,NG. Stoker Cholesterol utilisation in mycobacteria is controlled by two TetR-type transcriptional regulators; kstR and kstR2. Microbiology (Reading, England) 2010
InteractionRegulatory Rv3574activepriyadarshinipriyanka20012012-10-05
Co-expression (Functional linkage)
SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
InteractionRegulatedBy Rv3574activeyamir.moreno2012-10-05
M.smegmatis orthology based inference. Orthologous pair regulator-target found in M.smegmatis.
SL. Kendall, M. Withers et al. A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol. Microbiol. 2007
InteractionRegulatedBy Rv2711activeyamir.moreno2012-10-05
Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support.
G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
TermEC:1.3.1.24 Biliverdin reductase. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from its native host
X. Yang, E. Dubnau et al. Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 2007
TermEC:1.5.1.30 Flavin reductase. - NRactiveextern:JZUCKER2012-03-06
Assay of protein purified to homogeneity from its native host
X. Yang, E. Dubnau et al. Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 2007
TermEC:1.1.1.145 3-beta-hydroxy-Delta(5)-steroid dehydrogenase. - NRactivensampson2012-03-05
Reaction blocked in mutant
X. Yang, E. Dubnau et al. Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 2007
TermEC:5.3.3.1 Steroid Delta-isomerase. - NRactivensampson2012-03-05
Reaction blocked in mutant
X. Yang, E. Dubnau et al. Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 2007
TermEC:1.1.1.145 3-beta-hydroxy-Delta(5)-steroid dehydrogenase. - NRactivensampson2012-03-05
Assay of protein purified to homogeneity from a heterlogous host
X. Yang, E. Dubnau et al. Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 2007
TermEC:5.3.3.1 Steroid Delta-isomerase. - NRactivensampson2012-03-05
Assay of protein purified to homogeneity from a heterlogous host
X. Yang, E. Dubnau et al. Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 2007
Otherproduct:cholest-4-en-3-oneactiverslayden2012-03-05

X. Yang, E. Dubnau et al. Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 2007
TermEC:5.3.3.1 Steroid Delta-isomerase. - NRactiverslayden2012-03-05

X. Yang, E. Dubnau et al. Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 2007
TermEC:1.1.1.145 3-beta-hydroxy-Delta(5)-steroid dehydrogenase. - NRactiverslayden2012-03-05

X. Yang, E. Dubnau et al. Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 2007
Symbolhsdactiverslayden2012-03-05

X. Yang, E. Dubnau et al. Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 2007
Name3-beta hydroxysteroid dehydrogenaseactivecstolte2011-01-03
Yang (2007) biochemically characterize Rv1106c. Disruption prevents cholesterol oxidation.
SymbolHsdactivecstolte2011-01-03
Yang (2007) biochemically characterize Rv1106c. Disruption prevents cholesterol oxidation.
Name3-beta hydroxysteroid dehydrogenaseactivejgalag2010-09-02
Yang (2007) biochemically characterize Rv1106c. Disruption prevents cholesterol oxidation.
SymbolHsdactivejgalag2010-09-02
Yang (2007) biochemically characterize Rv1106c. Disruption prevents cholesterol oxidation.