Rv1127c - pyruvate, phosphate dikinase ppdK

Expression: Most Significant Conditions for Rv1127c

Protein Domains

Gene Information
Locus	Rv1127c
Symbol	ppdK
Gene Name	pyruvate, phosphate dikinase ppdK
Location	1249932 - 1251404 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:1473 bp Protein:491 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	36092
Related Genes	Acel_1936 cg1194 MAP2664 MAP2688 MAV_1225 MAV_1259 Mkms_4185 Mkms_4198 ML0955 ML1942 Mmcs_4109 Mmcs_4123 MSMEG_5228 MT1137 MT1159 MUL_0141 MUL_0172 Mvan_0427 Mvan_4635 nfa26860 PPA2048 Rv1106c
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1127c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1127c Transcript 1
MTRITRANGCPDGTLENAVVALDGGANYPREILGNKGHGIDMMRRHHLPVPPAFCITTEV
GVRYLAAPGSTIAAIWDDVLDRMSWLETETSCTFGRGPNPLLVSVRSGATQSMPGMMDTI
LDVGMTDAVERVLARPGAADFAHDTRRRFTSMYRRIVGSAGPITDDPYAQLRASIEAVFA
SWNSPRAVAYRDHHGLDDQGGTAVVVQAMVFGNLTANSGAGVLSSRNPITGANEPFGEWL
PGGQGDDVVSGLVAVAPITALRDQQPAVYDQLMAAARSLERMAGDVQEIEFTVEDSQLWL
LQTRGAERSAQAAVRLALQLHHEGLIDDTETLRRVTPTHIETLLRPSLQTETRLAAPLLA
KGLPACPGVVSGTAYTEVDEALDAADRGEPVILVRDHTRPEDVMGMLAAQGIVTEVGGAA
SHAAVVSRELGRVAVVGCGPGVAAALAGKEITVDGYEGEVRQGVLALSAWSESDTPELRE
LADIAQRISS*

Genomic Sequence

>Rv1127c
ATGACTCGTATCACCCGAGCCAATGGTTGCCCCGACGGAACTCTCGAAAACGCCGTTGTG
GCGCTGGACGGCGGCGCGAACTACCCACGCGAGATCCTGGGCAACAAAGGCCACGGCATC
GACATGATGCGCCGGCACCATCTGCCGGTGCCGCCTGCATTCTGCATTACCACCGAGGTG
GGCGTGCGCTATCTCGCCGCGCCCGGATCCACGATCGCCGCGATCTGGGATGACGTGCTG
GATCGGATGAGCTGGCTGGAAACAGAAACCTCGTGCACGTTCGGCCGTGGCCCGAATCCG
CTGCTGGTCAGCGTGCGCTCGGGAGCCACCCAGTCGATGCCCGGCATGATGGACACGATT
CTGGACGTGGGCATGACCGACGCGGTCGAACGAGTACTTGCCAGGCCGGGTGCCGCCGAC
TTCGCCCACGACACCAGACGGCGATTCACCAGCATGTATCGGCGCATCGTCGGCAGCGCC
GGTCCCATTACCGACGACCCGTATGCCCAGTTGCGCGCGAGCATCGAGGCGGTATTCGCC
TCCTGGAACTCACCTCGCGCCGTTGCCTATCGCGACCATCACGGCCTCGACGACCAAGGC
GGTACGGCGGTGGTGGTGCAGGCGATGGTATTCGGCAACCTCACCGCGAACTCGGGCGCC
GGGGTGCTGTCCTCACGCAACCCGATCACCGGAGCCAACGAACCGTTCGGCGAATGGCTA
CCCGGCGGCCAAGGCGACGACGTGGTGTCCGGATTGGTCGCCGTCGCACCGATCACCGCC
CTGCGCGACCAGCAGCCGGCCGTCTACGACCAACTGATGGCGGCCGCCCGCAGTTTGGAG
CGCATGGCAGGCGACGTCCAGGAGATCGAATTCACCGTGGAGGACAGCCAGCTGTGGCTG
CTGCAGACCCGCGGGGCGGAACGCTCGGCGCAGGCCGCCGTGCGACTGGCGCTGCAACTG
CATCACGAGGGACTCATCGACGACACCGAGACACTGCGCCGGGTGACTCCGACGCACATC
GAGACTTTGCTACGGCCGTCGCTGCAGACGGAAACACGGTTGGCTGCACCGCTTTTGGCC
AAGGGCCTGCCCGCTTGCCCGGGCGTGGTATCCGGGACCGCCTACACCGAGGTGGACGAG
GCGCTGGACGCTGCGGACCGGGGCGAGCCGGTCATCTTGGTGCGAGATCACACCAGACCG
GAGGACGTCATGGGCATGCTTGCCGCGCAAGGCATTGTCACCGAGGTGGGGGGTGCCGCC
AGTCATGCGGCGGTGGTTAGCCGCGAGCTCGGTCGAGTGGCCGTGGTGGGTTGCGGTCCC
GGGGTCGCGGCGGCACTGGCCGGCAAGGAGATCACCGTCGACGGCTATGAAGGCGAAGTG
CGCCAAGGCGTTCTGGCATTGTCTGCCTGGTCGGAAAGTGACACGCCGGAGTTGCGCGAG
CTGGCCGACATCGCGCAACGGATCAGTTCATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	RegulatedBy Rv1785c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv1221	active	yamir.moreno	2012-10-05
	Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balázsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv1785c	active	yamir.moreno	2012-10-05
	E.coli orthology based inference. Orthologous pair regulator-target found in E.coli. authors,M. Madan Babu,SA. Teichmann,L. Aravind Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J. Mol. Biol. 2006
Term	EC:2.7.9.1 Pyruvate, phosphate dikinase. - NR	active	extern:JZUCKER	2012-03-06
	Traceable author statement to experimental support authors,KY. Rhee,LP. de Carvalho,R. Bryk,S. Ehrt,J. Marrero,SW. Park,D. Schnappinger,A. Venugopal,C. Nathan Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 2011