Rv1181 - polyketide beta-ketoacyl synthase pks4

Expression: Most Significant Conditions for Rv1181

Protein Domains

Gene Information
Locus	Rv1181
Symbol	pks4
Gene Name	polyketide beta-ketoacyl synthase pks4
Location	1315234 - 1319982 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:4749 bp Protein:1583 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	31305
Related Genes	ML1229 MT1218 Rv1180
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv1181
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv1181 Transcript 1
MTASSFDELSAALRDVAGDQIPYQPAVGHDDRGPVWVFSGQGSQWPGMGTELLVAEPVFA
ATVAAMEPVIARESGFSVTEAMSAPQTVSGIDRVQPTIFAVQVALAAALKSYGVRPGAII
GHSLGEAAAAVVAGALSLHDGLRVICRRSRLMSRIAGSGAMASVELPGQQVLSELAIRGI
SDVVLSVVASPTSTVVGGATQSIRDLVAAWEQQDVLAREVAVDVASHTPQVDPILDELLE
VLAEVDPTAPEIPYYSATLWDPRERPSFTGEYWVENLRYTVRFAAAVQAALKDGYRVFGE
LAPHPLLTYAVEQNAASLDMPIATLAAMRRGEQLPFGLRGFVADVHNAGAKVDFSVQYPD
GRLVDAPLPSWTHRTLMLSREDSHRSHTGAVQAVHPLLGAHVHLLEEPERHVWQAGVGTG
AHPWLGDHRIHNVAAFPGAAYCEMALAAARTTLGELSEVRDIKFEQTLLLDEQTVVSSAA
TIAAPGILQFAVESHQEGEPARRASAMLHALEEMPQPPGYDTNALTAAHESSMSGEELRK
MFNSLGIQYGPAFSGLVAVHTARGDVTTVLAEVALPGAIRSQQSAYASHPALLDACFQSV
LVHPEVQKATVGGLMLPVGVRRLRNYHSTRSAHYCLARVTSSSRAGECEADLDVFDQAGT
VLLTVEGLRLAAGISEHERANRVFDERLLTIEWERGELPEVPQIDAGSWLLLSASEADPL
TAQLADALNAVGAQSTSVASASDVAQLRSLLGGRLTGVVVVTGPPTGGLTQCGRDYVSQL
VGIARELAELPGEPPRLFVVTRSAASVLPSDLANLEQAGLRGLMRVIDSEHPHLGATAID
VDNDETVAALVASQLQSGSQEDETAWRNGIWYTARLRPGPLRPAERRTAVVEYRRDGMRL
QIRTPGDLESLEFVTFDRVAPGPGEIEVAVTASSVNFADVLVAFGRYPTFEGYRQQLGID
FAGVVTAVGPDVTEHRIGDHVGGMSANGCWSTFVRCDARLAVTLPPELPVAAAAAVPTAS
ATAWYALHDLARICSDDKVLIHSGTGGVGQAAIAIARAAGCEIFATAGSAQRRQLLHDMG
VEHVYDSRSTEFAEQIRGDTDGYGVDVVLNSLPGAAQRAGIELLAFGGRFVEIGKRDIYG
DTRLGLFPFRRNLSLYAVDLALLTHSHPHTVRRLLKTVYQHTVEGTLPVPQTTHYPIHDA
AVAIRLVGGAGHTGKVVLDVPRTGEGVAVVPPEQVRTSRPDGAYLVTGGLGGLGLFLAGE
LAAAGCGRIVLNSRSTPSPHATRVIERLRAAGADIQVECGDIADAATAHRVVAVATASGL
PVRGVLHAAAVVEDATLANVTDELIDRCWAPKVHGAWNIHRATAAQPLEWFCLFSSAAAL
VGSPGQGAYAAANSWLDAFAHWRRAQGLPATSIAWGAWAEIGRATALAEGTGAAIAPAEG
ARAFQTLLRYGRAYSGYAPIMGTPWLTAFAQRSRFAEAFHATGQNQPATGKFLAELGSLP
REEWPRTVRRLVSDQISLLLRRTIDPDRPLSDYGLDSLGNLELRTRIETETGIRVSPTKI
TTVRGLAEHVCDELAAAQSAPV*

Genomic Sequence

>Rv1181
GTGACGGCGAGCAGTTTTGACGAGCTGAGCGCGGCGCTGCGGGACGTCGCTGGCGATCAG
ATTCCCTATCAGCCCGCAGTGGGGCACGACGACCGCGGGCCGGTGTGGGTGTTCTCCGGG
CAAGGCTCTCAGTGGCCCGGGATGGGCACTGAACTGCTGGTAGCCGAACCGGTGTTCGCC
GCCACCGTCGCGGCGATGGAGCCGGTGATCGCTAGGGAGTCAGGGTTTTCGGTGACCGAA
GCGATGTCGGCGCCACAGACGGTCAGCGGTATTGACCGGGTGCAGCCCACCATCTTCGCG
GTGCAGGTCGCCCTGGCCGCGGCCCTGAAGTCGTATGGGGTACGTCCTGGTGCCATCATC
GGGCACTCGCTCGGCGAGGCTGCGGCAGCCGTGGTCGCCGGAGCACTGTCGCTGCACGAC
GGATTGCGAGTCATCTGCCGGCGCTCGCGGCTGATGTCGCGCATCGCCGGTAGTGGCGCG
ATGGCATCGGTGGAACTGCCCGGCCAACAAGTGTTGTCAGAACTTGCGATTCGTGGGATC
TCCGACGTCGTGCTCTCGGTGGTTGCCTCTCCGACCTCAACCGTCGTCGGCGGCGCCACG
CAGTCGATACGTGACCTGGTGGCGGCCTGGGAGCAGCAGGATGTGCTGGCGCGCGAGGTA
GCTGTGGACGTCGCTTCACATACACCGCAGGTCGATCCCATCCTGGACGAGTTGCTCGAG
GTCCTGGCCGAGGTCGATCCGACGGCGCCGGAAATTCCGTATTACTCCGCAACGTTGTGG
GATCCGCGCGAGCGACCGTCGTTCACCGGCGAGTACTGGGTGGAAAACCTGCGGTACACG
GTGCGATTCGCGGCGGCGGTACAGGCCGCGCTCAAGGACGGGTACCGAGTGTTCGGCGAG
CTGGCTCCGCATCCGCTGCTCACCTACGCGGTCGAGCAGAACGCCGCCAGTCTCGACATG
CCGATCGCAACGCTTGCCGCGATGCGGCGCGGGGAACAGCTGCCGTTCGGGTTGCGCGGC
TTCGTCGCCGACGTGCACAACGCCGGCGCCAAGGTGGACTTCTCTGTCCAGTACCCTGAT
GGGCGCTTGGTGGATGCGCCATTGCCGAGCTGGACGCACCGCACCCTGATGCTCAGCCGT
GAGGATTCACACCGCTCGCACACCGGCGCGGTCCAGGCGGTTCATCCGCTGCTTGGGGCC
CATGTGCACCTGTTGGAGGAACCGGAGCGTCACGTCTGGCAGGCCGGGGTTGGCACCGGG
GCGCATCCGTGGCTCGGTGACCATCGGATACACAACGTGGCTGCGTTTCCCGGTGCGGCC
TACTGTGAGATGGCATTGGCCGCGGCGCGCACCACTCTTGGCGAGCTGTCGGAGGTGCGC
GACATCAAGTTCGAGCAGACGCTGTTGCTGGACGAGCAGACGGTGGTCTCATCGGCCGCG
ACGATCGCCGCGCCTGGGATCCTACAGTTCGCAGTCGAGAGTCATCAGGAAGGCGAGCCC
GCACGGCGGGCCAGCGCGATGCTGCACGCATTGGAGGAGATGCCGCAGCCGCCCGGGTAC
GACACGAACGCTCTGACCGCCGCCCATGAGTCCAGCATGAGCGGTGAGGAACTGCGAAAA
ATGTTTAACAGCTTAGGTATTCAGTATGGTCCGGCTTTTTCAGGCCTAGTTGCGGTGCAC
ACGGCGCGCGGGGACGTCACCACAGTGCTCGCCGAGGTCGCGCTGCCTGGAGCCATCCGA
TCTCAGCAGTCGGCATATGCCAGCCACCCGGCCCTGCTTGATGCGTGTTTCCAGTCGGTG
CTTGTTCATCCCGAGGTCCAGAAGGCGACTGTCGGTGGTCTGATGCTGCCCGTGGGCGTG
CGTAGGCTGCGCAACTATCACTCGACGCGCAGCGCGCACTACTGCCTCGCCCGGGTCACG
TCATCGTCGCGAGCCGGCGAATGCGAAGCCGATCTCGACGTGTTCGACCAGGCCGGAACG
GTACTTTTGACCGTCGAGGGATTACGGCTGGCCGCAGGGATTTCCGAACATGAACGCGCG
AACCGGGTGTTCGACGAGCGATTGTTGACCATCGAGTGGGAGCGGGGTGAGCTGCCTGAG
GTGCCGCAGATCGATGCGGGATCCTGGCTGCTGCTCAGTGCGTCCGAAGCTGATCCGCTG
ACCGCGCAACTCGCCGACGCGTTGAATGCCGTTGGTGCCCAGAGCACTAGCGTGGCTTCG
GCGTCGGATGTCGCACAATTGCGTTCGCTGCTCGGAGGCAGGCTCACCGGTGTTGTCGTG
GTGACTGGCCCGCCAACGGGTGGTTTGACACAGTGCGGCCGCGACTATGTGTCACAGCTG
GTGGGTATTGCCCGCGAGCTCGCGGAGCTGCCCGGTGAGCCGCCGCGGCTGTTCGTGGTG
ACCAGGAGCGCGGCGAGCGTGCTGCCGAGCGATCTTGCCAACTTGGAACAGGCGGGATTG
CGTGGACTGATGCGGGTGATCGATTCCGAGCATCCGCACCTGGGTGCCACCGCAATCGAC
GTCGACAACGACGAGACCGTCGCTGCCCTGGTGGCCAGCCAACTACAGAGCGGGTCGCAG
GAGGACGAAACCGCTTGGCGCAATGGCATTTGGTACACCGCCCGGCTGCGTCCCGGTCCG
TTACGCCCGGCCGAACGGCGAACCGCCGTCGTCGAATACAGACGCGACGGTATGCGCCTG
CAGATCCGCACTCCCGGCGACCTCGAGTCGTTGGAGTTCGTCACATTCGACCGGGTCGCG
CCGGGACCGGGCGAGATCGAGGTCGCGGTGACCGCATCGAGTGTCAACTTCGCCGACGTT
CTGGTCGCTTTCGGGCGGTATCCCACCTTCGAGGGCTACCGACAGCAGTTGGGCATCGAC
TTCGCCGGTGTGGTGACCGCGGTCGGGCCGGATGTCACCGAGCATCGGATCGGTGATCAC
GTCGGCGGCATGTCCGCCAATGGCTGCTGGAGCACATTCGTCAGATGCGATGCCCGGCTG
GCGGTGACGCTCCCGCCCGAGCTGCCGGTGGCCGCCGCCGCCGCGGTACCGACCGCCTCC
GCGACGGCTTGGTACGCCCTGCACGATCTGGCTCGCATCTGCTCGGACGACAAGGTGCTG
ATTCACTCGGGGACCGGTGGTGTCGGGCAGGCGGCGATCGCGATCGCACGGGCCGCCGGA
TGCGAGATCTTCGCCACCGCGGGCAGTGCCCAGCGGCGACAACTGCTGCACGACATGGGT
GTCGAGCATGTCTACGACTCACGGAGCACCGAGTTCGCCGAGCAGATCCGAGGCGACACC
GATGGGTATGGTGTCGACGTCGTACTCAACTCGCTGCCCGGCGCCGCACAACGTGCTGGG
ATCGAATTGCTGGCCTTTGGCGGGCGATTCGTGGAGATCGGCAAACGTGACATCTACGGC
GACACTCGGCTCGGGTTGTTCCCGTTCCGCCGCAACCTGTCGCTGTATGCCGTCGACTTG
GCGCTGCTGACACACAGCCACCCGCACACCGTCCGGCGCCTGCTGAAAACCGTCTACCAA
CACACGGTCGAGGGCACGCTGCCGGTGCCGCAGACCACGCACTATCCCATTCACGACGCT
GCCGTTGCCATTCGTTTGGTCGGCGGAGCCGGGCACACCGGAAAAGTGGTGCTCGATGTG
CCGCGTACCGGTGAAGGCGTGGCCGTGGTGCCCCCCGAACAGGTCCGCACGTCCCGGCCC
GACGGCGCCTATCTCGTCACCGGTGGTTTGGGCGGCCTCGGCCTGTTCCTTGCCGGCGAG
CTGGCGGCGGCGGGCTGCGGACGCATCGTGCTCAACTCCCGTTCGACGCCCAGCCCGCAC
GCCACCAGGGTCATCGAGCGGCTCCGCGCCGCCGGTGCTGATATCCAGGTGGAATGCGGT
GACATCGCTGATGCCGCAACGGCCCACCGAGTGGTGGCGGTGGCCACCGCCTCGGGCTTG
CCGGTGCGCGGCGTGCTGCACGCGGCGGCGGTGGTCGAGGACGCTACGTTGGCCAATGTC
ACCGACGAACTTATCGACCGCTGTTGGGCGCCGAAGGTACACGGCGCGTGGAACATTCAT
CGGGCCACCGCCGCGCAGCCACTGGAGTGGTTCTGCTTGTTCTCCTCGGCCGCGGCCTTG
GTGGGCTCGCCGGGTCAAGGCGCATATGCGGCGGCCAACAGCTGGTTGGACGCTTTTGCC
CACTGGCGGCGGGCGCAGGGCCTTCCGGCTACCTCAATCGCCTGGGGAGCATGGGCCGAG
ATTGGCCGCGCTACCGCGCTGGCCGAAGGCACCGGCGCAGCGATCGCGCCCGCCGAGGGT
GCTCGAGCCTTCCAGACGCTGCTTCGCTACGGCCGGGCGTACTCCGGCTATGCCCCGATC
ATGGGTACCCCATGGTTGACGGCCTTTGCGCAACGTAGCCGATTTGCCGAAGCGTTCCAC
GCCACGGGCCAAAATCAACCGGCCACCGGGAAATTCCTCGCCGAACTGGGCAGCTTGCCC
CGCGAAGAGTGGCCCCGCACAGTCAGGCGGTTGGTATCGGACCAGATCAGCCTGCTGCTG
CGGCGAACCATTGATCCGGACCGGCCGCTGTCCGACTATGGTTTGGATTCCTTGGGCAAC
TTGGAGTTGCGGACCCGCATCGAAACCGAAACGGGTATACGCGTCAGTCCCACAAAGATC
ACCACGGTTCGCGGCTTGGCCGAGCACGTGTGCGACGAGCTGGCAGCCGCCCAATCTGCG
CCGGTCTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Name	Together with Pks3, polyketide synthase involved in the synthesis of mycolipenic and mycosanoic acids	active	mjackson	2012-10-05
	Polymethyl-branched acyltrehaloses
Other	TBPWY:Polymethyl-branched acyltrehaloses	active	mjackson	2012-03-05
	Together with Pks3, polyketide synthase involved in the synthesis of mycolipenic and mycosanoic acids (phenotypic [mycobacterial recombinant strains]) authors,C. Rousseau,O. Neyrolles,Y. Bordat,S. Giroux,TD. Sirakova,MC. Prevost,PE. Kolattukudy,B. Gicquel,M. Jackson Deficiency in mycolipenate- and mycosanoate-derived acyltrehaloses enhances early interactions of Mycobacterium tuberculosis with host cells. Cell. Microbiol. 2003
Other	TBPWY:Polymethyl-branched acyltrehaloses	active	mjackson	2012-03-05
	Together with Pks3, polyketide synthase involved in the synthesis of mycolipenic and mycosanoic acids (phenotypic [mycobacterial recombinant strains]) VS. Dubey, TD. Sirakova et al. Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation. Mol. Microbiol. 2002
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay VS. Dubey, TD. Sirakova et al. Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation. Mol. Microbiol. 2002