Rv2931 - phenolpthiocerol synthesis type-I polyketide synthase ppsA

Expression: Most Significant Conditions for Rv2931

Protein Domains

Gene Information
Locus	Rv2931
Symbol	ppsA
Gene Name	phenolpthiocerol synthesis type-I polyketide synthase ppsA
Location	3245445 - 3251075 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:5631 bp Protein:1877 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	25808
Related Genes	Mkms_2878 Mkms_2879 ML2356 ML2357 ML2358 Mmcs_2834 Mmcs_2835 MSMEG_6767 MT2999 MT3000 MT3002 MT3003 MUL_2018 MUL_2019 MUL_2020 Mvan_3125 Mvan_3126 Mvan_3128 Rv2930 Rv2932 Rv2933
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2931
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2931 Transcript 1
MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLSGELSELLGRT
VSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGARNSLDEPIAVVGMGCRFPGGISCP
EALWDFLCERRSSISQVPPQRWQPFEGGPPEVAAALARTTRWGSFLPDIDAFDAEFFEIS
PSEADKMDPQQRLLLEVAWEALEHAGIPPGTLRRSATGVFAGACLSEYGAMASADLSQVD
GWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRTQDCHLAIAAGV
NLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGEGAGVVVLKRLTDAQRDGDRVLA
VICGSAVNQDGRSNGLMAPNPAAQMAVLRAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEA
RALGTVLGRGRPEDSPLLIGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQHFETAN
PHIPFTDLRMKVVDTQTEWPATGHPRRAGVSSFGFGGTNAHVVIEQGQEVRPAPGQGLSP
AVSTLVVAGKTMQRVSATAGMLADWMEGPGADVALADVAHTLNHHRSRQPKFGTVVARDR
TQAIAGLRALAAGQHAPGVVNPADGSPGPGTVFVYSGRGSQWAGMGRQLLADEPAFAAAV
AELEPVFVEQAGFSLHDVLANGEELVGIEQIQLGLIGMQLALTELWCSYGVRPDLVIGHS
MGEVAAAVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLELDAPTTEALIADFPQVTL
GIYNSPRQTVIAGPTEQIDELIARVRAQNRFASRVNIEVAPHNPAMDALQPAMRSELADL
TPRTPTIGIISTTYADLHTQPVFDAEHWATNMRNPVRFQQAIASAGSGADGAYHTFIEIS
AHPLLTQAIIDTLHSAQPGARYTSLGTLQRDTDDVVTFRTNLNKAHTIHPPHTPHPPEPH
PPIPTTPWQHTRHWITTKYPAGSVGSAPRAGTLLGQHTTVATVSASPPSHLWQARLAPDA
KPYQGGHRFHQVEVVPASVVLHTILSAATELGYSALSEVRFEQPIFADRPRLIQVVADNR
AISLASSPAAGTPSDRWTRHVTAQLSSSPSDSASSLNEHHRANGQPPERAHRDLIPDLAE
LLAMRGIDGLPFSWTVASWTQHSSNLTVAIDLPEALPEGSTGPLLDAAVHLAALSDVADS
RLYVPASIEQISLGDVVTGPRSSVTLNRTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRA
LDFGLDVGRAQPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIG
DDGAALCETLEGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFAVRICTEITGLV
RTLAERDADKPAALWILTRGVHESVAPSALRQSFLWGLAGVIAAEHPELWGGLVDLAIND
DLGEFGPALAELLAKPSKSILVRRDGVVLAPALAPVRGEPARKSLQCRPDAAYLITGGLG
ALGLLMADWLADRGAHRLVLTGRTPLPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEA
VAADVGCREDVQALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVRQVMWPKIGGS
QVLHDAFPPGSVDFFYLTASAAGIFGIPGQGSYAAANSYLDALARARRQQGCHTMSLDWV
AWRGLGLAADAQLVSEELARMGSRDITPSEAFTAWEFVDGYDVAQAVVVPMPAPAGADGS
GANAYLLPARNWSVMAATEVRSELEQGLRRIIAAELRVPEKELDTDRPFAELGLNSLMAM
AIRREAEQFVGIELSATMLFNHPTVKSLASYLAKRVAPHDVSQDNQISALSSSAGSVLDS
LFDRIESAPPEAERSV*

Genomic Sequence

>Rv2931
ATGACGGGAAGCATCAGTGGTGAAGCCGACCTTCGCCACTGGCTAATCGACTACCTAGTA
ACCAATATCGGCTGCACACCTGACGAGGTGGACCCCGATCTGTCGCTTGCCGACCTCGGC
GTCAGCTCCCGCGACGCGGTCGTACTGTCCGGCGAACTGTCAGAGCTGCTGGGCAGGACC
GTATCGCCGATTGACTTCTGGGAGCACCCGACGATCAACGCGCTGGCCGCGTATCTGGCC
GCACCCGAGCCGAGCCCCGACTCCGACGCCGCAGTCAAGCGTGGTGCCCGGAACTCACTC
GACGAGCCAATCGCCGTCGTCGGCATGGGATGTCGTTTCCCTGGCGGGATTTCGTGCCCA
GAAGCATTGTGGGACTTTCTCTGTGAACGCCGTTCCTCGATCAGCCAGGTGCCGCCGCAA
CGATGGCAGCCCTTCGAAGGCGGGCCACCCGAGGTAGCCGCGGCGCTAGCGCGCACTACA
CGGTGGGGCTCATTTTTGCCCGACATCGACGCCTTCGACGCGGAATTCTTCGAGATCTCC
CCCAGCGAAGCCGACAAGATGGACCCCCAGCAACGCCTGCTGCTGGAAGTGGCCTGGGAA
GCGTTGGAGCACGCGGGAATCCCGCCCGGCACGCTGCGCCGCTCGGCAACAGGAGTGTTT
GCCGGGGCATGCCTGAGCGAATACGGTGCGATGGCTTCCGCCGATCTGTCGCAGGTCGAT
GGTTGGAGCAATAGCGGTGGCGCGATGAGCATCATCGCCAACCGCCTCTCGTATTTCCTT
GACCTGCGCGGCCCGTCGGTGGCGGTAGACACCGCATGCTCGTCGTCGTTGGTAGCGATC
CACCTGGCCTGCCAGAGCCTTCGGACCCAGGACTGTCACCTGGCAATCGCAGCCGGCGTG
AATTTGTTGTTGTCCCCGGCGGTATTTCGCGGTTTCGACCAAGTCGGCGCCTTGTCCCCG
ACAGGTCAGTGCCGTGCGTTCGATGCGACCGCCGACGGGTTTGTCCGCGGCGAGGGTGCC
GGGGTAGTGGTGCTCAAGCGGTTGACCGATGCACAGCGCGACGGGGATCGGGTGCTTGCG
GTGATCTGCGGTTCTGCGGTCAACCAGGACGGCCGATCCAACGGGCTGATGGCCCCCAAC
CCAGCGGCCCAGATGGCGGTGCTGCGTGCCGCCTACACCAACGCGGGGATGCAGCCCAGC
GAGGTCGACTACGTCGAAGCGCACGGAACAGGGACGCTGTTGGGCGACCCGATCGAAGCC
CGCGCTCTCGGAACGGTGCTGGGTCGCGGCCGGCCCGAGGATTCTCCGTTGCTCATCGGC
TCTGTCAAGACCAACCTCGGTCACACCGAGGCTGCGGCTGGAATCGCGGGCTTCATCAAG
ACGGTGCTGGCTGTGCAGCATGGCCAGATTCCGCCAAATCAGCACTTCGAAACCGCGAAC
CCGCACATTCCCTTTACCGACTTGCGGATGAAAGTCGTTGACACACAAACTGAATGGCCG
GCAACGGGCCATCCCCGCCGTGCCGGTGTGTCGTCGTTCGGCTTCGGTGGCACAAACGCG
CACGTGGTGATCGAGCAGGGCCAGGAGGTGCGCCCCGCGCCTGGACAAGGCTTAAGTCCG
GCGGTGTCGACCCTGGTAGTGGCCGGCAAGACTATGCAGCGGGTGTCCGCGACCGCGGGG
ATGCTAGCCGATTGGATGGAAGGGCCCGGCGCTGACGTGGCCTTGGCCGACGTGGCCCAC
ACCCTCAATCACCACCGATCGCGGCAACCCAAGTTCGGCACGGTGGTGGCCCGTGACCGT
ACCCAGGCGATAGCCGGATTGCGTGCGCTGGCCGCCGGCCAACACGCCCCCGGCGTGGTC
AACCCTGCCGACGGCTCGCCGGGGCCGGGCACCGTGTTCGTCTACTCCGGCCGCGGTTCA
CAGTGGGCTGGCATGGGCCGTCAATTGTTGGCCGACGAGCCGGCTTTCGCGGCCGCGGTC
GCCGAATTGGAACCGGTGTTTGTCGAGCAAGCCGGCTTTTCGTTGCACGACGTGCTGGCT
AACGGCGAGGAACTGGTCGGTATCGAGCAGATTCAGCTCGGGTTGATCGGGATGCAGCTG
GCCCTGACCGAATTATGGTGTTCCTACGGGGTGCGGCCCGACCTGGTGATCGGCCACTCC
ATGGGCGAGGTGGCCGCCGCCGTGGTCGCCGGGGCACTGACCCCGGCCGAGGGTCTGCGG
GTGACCGCCACCCGGTCACGGCTGATGGCACCGTTGTCCGGCCAGGGCGGCATGGCACTG
CTGGAACTCGACGCGCCCACTACCGAGGCGTTGATTGCCGACTTCCCACAGGTGACGCTC
GGTATTTACAACTCACCACGGCAAACGGTGATCGCCGGGCCCACCGAGCAGATCGATGAG
TTGATCGCCCGGGTGCGCGCGCAAAACCGGTTTGCCAGTCGGGTCAATATCGAAGTGGCC
CCGCACAATCCGGCCATGGATGCTTTGCAGCCGGCGATGCGTTCGGAGCTGGCCGATCTG
ACCCCACGGACCCCCACCATCGGAATCATCTCCACCACCTACGCAGACTTGCACACCCAA
CCGGTCTTCGACGCCGAACACTGGGCCACCAACATGCGCAACCCCGTGCGCTTCCAGCAG
GCCATCGCTTCCGCCGGTAGCGGCGCCGACGGCGCCTACCACACCTTCATCGAAATCAGC
GCACACCCGCTGCTGACCCAGGCCATCATCGACACTCTGCACAGCGCTCAACCCGGAGCC
AGATACACCAGCCTCGGGACCCTGCAACGCGACACCGACGACGTCGTGACCTTCCGGACC
AACCTCAACAAGGCCCACACCATCCACCCACCGCACACCCCCCACCCCCCCGAGCCACAT
CCGCCCATCCCCACCACCCCGTGGCAACACACCCGTCACTGGATCACCACCAAATATCCG
GCCGGCTCTGTTGGATCGGCCCCCCGAGCGGGCACACTGCTCGGCCAACACACCACCGTC
GCCACGGTCTCAGCGAGTCCGCCCTCCCACCTCTGGCAAGCAAGGCTGGCTCCGGACGCC
AAGCCGTACCAGGGCGGTCATCGATTCCACCAAGTCGAGGTGGTCCCAGCTTCTGTTGTG
CTGCACACAATCCTTTCCGCTGCAACAGAATTGGGCTACTCCGCGTTGTCCGAGGTCCGA
TTCGAGCAACCCATTTTCGCCGACCGGCCACGTCTAATCCAGGTCGTCGCCGACAACCGG
GCGATCAGCCTGGCCTCGAGTCCGGCTGCCGGAACACCCTCAGACCGGTGGACGCGGCAT
GTTACCGCACAACTTTCCTCGTCACCGTCGGATTCGGCCAGCAGCTTGAACGAGCACCAT
CGCGCCAACGGGCAGCCGCCCGAACGTGCTCACCGCGACCTGATTCCCGACCTGGCCGAG
CTGCTCGCAATGCGCGGCATCGATGGCCTGCCTTTCTCATGGACCGTCGCGTCGTGGACA
CAGCACTCGAGCAACCTCACGGTTGCGATCGATCTCCCCGAAGCTCTGCCCGAAGGGTCG
ACTGGGCCGCTCCTTGACGCCGCGGTGCACCTCGCCGCGCTATCGGACGTCGCTGATTCG
CGGCTCTACGTGCCGGCAAGCATCGAGCAGATATCGCTCGGCGATGTCGTCACCGGGCCG
CGTAGCTCGGTGACGCTGAACCGCACCGCTCACGACGACGACGGGATCACCGTCGATGTC
ACCGTTGCAGCCCACGGCGAAGTGCCGTCCCTGTCGATGAGGTCGCTTCGATACCGGGCT
CTGGACTTTGGCCTAGACGTTGGTAGGGCGCAACCGCCCGCGTCGACCGGTCCGGTCGAG
GCCTACTGTGATGCCACCAATTTCGTACACACGATCGACTGGCAACCGCAGACCGTTCCG
GACGCGACGCACCCAGGGGCCGAACAGGTAACCCATCCAGGACCCGTCGCGATAATCGGC
GATGACGGCGCAGCGCTGTGTGAGACCCTCGAAGGGGCGGGCTACCAGCCGGCCGTGATG
TCCGATGGGGTGTCGCAGGCCCGCTACGTCGTTTACGTCGCGGATTCTGATCCGGCTGGC
GCCGACGAGACCGACGTCGACTTCGCCGTCCGGATCTGTACCGAAATCACCGGTCTGGTG
CGGACTCTCGCGGAACGCGATGCGGATAAGCCCGCGGCGCTATGGATCCTCACCCGCGGA
GTTCACGAATCGGTCGCCCCGTCCGCGCTGCGCCAGAGTTTCCTGTGGGGCCTTGCCGGT
GTCATCGCCGCCGAACATCCCGAGCTGTGGGGCGGACTGGTCGATCTCGCGATCAACGAC
GACTTAGGCGAATTCGGGCCGGCACTTGCCGAACTGCTTGCCAAACCAAGCAAGTCGATC
TTGGTGCGTCGTGACGGCGTGGTGCTCGCCCCGGCCTTGGCTCCCGTCCGTGGCGAGCCG
GCGCGCAAGTCCTTGCAGTGCAGGCCCGACGCGGCCTACCTCATCACCGGCGGCCTGGGC
GCCCTTGGCCTGCTGATGGCCGATTGGCTCGCCGACCGCGGCGCTCATCGATTGGTGTTG
ACCGGCCGCACGCCATTGCCGCCACGGCGGGACTGGCAACTCGACACCCTCGACACCGAG
CTGCGCCGGAGGATCGACGCGATCCGCGCCCTGGAAATGCGCGGGGTGACTGTCGAAGCC
GTCGCCGCCGACGTCGGCTGCCGCGAAGACGTGCAGGCCCTGTTGGCCGCGCGCGACCGT
GACGGAGCGGCACCGATCCGCGGGATCATCCACGCCGCGGGCATTACCAACGATCAATTG
GTGACGAGCATGACCGGCGATGCGGTGCGACAGGTTATGTGGCCGAAGATCGGCGGCAGC
CAGGTCCTACACGACGCATTTCCGCCCGGCAGCGTGGACTTCTTCTACTTGACCGCCTCG
GCTGCCGGGATATTCGGCATTCCAGGGCAGGGTTCCTACGCCGCCGCCAATTCCTACTTG
GACGCGCTGGCGCGGGCGCGCCGGCAACAGGGCTGCCACACCATGAGCCTCGACTGGGTA
GCCTGGCGGGGGCTCGGATTGGCCGCGGACGCCCAGCTCGTCAGCGAAGAGCTAGCGCGA
ATGGGTTCGCGTGACATCACGCCGTCGGAGGCATTCACCGCTTGGGAATTCGTCGATGGC
TACGACGTCGCGCAAGCGGTCGTGGTGCCCATGCCCGCTCCGGCGGGCGCCGATGGATCC
GGTGCGAACGCTTACCTATTGCCGGCGCGGAACTGGTCGGTGATGGCAGCGACCGAGGTG
CGATCCGAGCTCGAACAGGGGTTACGCCGCATCATTGCAGCCGAGCTGCGAGTGCCTGAG
AAAGAGCTGGACACCGACCGCCCGTTCGCCGAGTTGGGTCTCAATTCCCTTATGGCAATG
GCGATTCGGCGCGAGGCCGAGCAGTTTGTCGGCATCGAGTTGTCTGCCACCATGTTGTTC
AACCACCCAACGGTCAAATCACTCGCCAGCTACCTTGCCAAACGTGTGGCACCGCACGAT
GTGTCACAAGACAACCAGATTTCCGCGCTATCCTCGTCGGCCGGAAGTGTGTTGGACAGT
CTATTCGATCGCATCGAATCGGCGCCGCCTGAGGCCGAGAGGTCGGTGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:PREPTHS2 phenolic phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 A. Rao & A. Ranganathan Interaction studies on proteins encoded by the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Mol. Genet. Genomics 2004
Term	TBRXN:PREPTHS2 phenolic phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,AK. Azad,TD. Sirakova,ND. Fernandes,PE. Kolattukudy Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria. J. Biol. Chem. 1997
Term	TBRXN:PREPTHS2 phenolic phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,DE. Minnikin,L. Kremer,LG. Dover,GS. Besra The methyl-branched fortifications of Mycobacterium tuberculosis. Chem. Biol. 2002
Term	TBRXN:PREPTHS phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 A. Rao & A. Ranganathan Interaction studies on proteins encoded by the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Mol. Genet. Genomics 2004
Term	TBRXN:PREPTHS phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,AK. Azad,TD. Sirakova,ND. Fernandes,PE. Kolattukudy Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria. J. Biol. Chem. 1997
Term	TBRXN:PREPTHS phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,DE. Minnikin,L. Kremer,LG. Dover,GS. Besra The methyl-branched fortifications of Mycobacterium tuberculosis. Chem. Biol. 2002
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2933	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2933	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2932	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2932	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2938	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2937	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2936	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2933	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2932	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2938	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2937	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2936	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2933	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2932	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	Regulatory Rv3692	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv3416	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv2745c	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv2034	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv0445c	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv0117	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv3692	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv3416	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv2745c	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv2034	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv0445c	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv0117	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	RegulatedBy Rv3911	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. S. Raman, X. Puyang et al. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv3692	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv3416	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv2745c	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv1956	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv1359	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0445c	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0117	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Name	Type 1 polyketide synthase responsible with PpsB-C-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively	active	mjackson	2012-10-05
	Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
Name	Type 1 polyketide synthase responsible with PpsB-C-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively	active	mjackson	2012-10-05
	Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	Type 1 polyketide synthase responsible with PpsB-C-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively (phenotypic [mycobacterial recombinant strains]; enzymatic) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	Type 1 polyketide synthase responsible with PpsB-C-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively (phenotypic [mycobacterial recombinant strains]; enzymatic) OA. Trivedi, P. Arora et al. Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid. Mol. Cell 2005
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay P. Constant, E. Perez et al. Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene. J. Biol. Chem. 2002