Rv2933 - phenolpthiocerol synthesis type-I polyketide synthase ppsC

Expression: Most Significant Conditions for Rv2933

Protein Domains

Gene Information
Locus	Rv2933
Symbol	ppsC
Gene Name	phenolpthiocerol synthesis type-I polyketide synthase ppsC
Location	3255685 - 3262251 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:6567 bp Protein:2189 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	25808
Related Genes	Mkms_2878 Mkms_2879 ML2356 ML2357 ML2358 Mmcs_2834 Mmcs_2835 MSMEG_6767 MT2999 MT3000 MT3002 MT3003 MUL_2018 MUL_2019 MUL_2020 Mvan_3125 Mvan_3126 Mvan_3128 Rv2930 Rv2931 Rv2932
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2933
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2933 Transcript 1
MTAATPDRRAIITEALHKIDDLTARLEIAEKSSSEPIAVIGMGCRFPGGVNNPEQFWDLL
CAGRSGIVRVPAQRWDADAYYCDDHTVPGTICSTEGGFLTSWQPDEFDAEFFSISPREAA
AMDPQQRLLIEVAWEALEDAGVPQHTIRGTQTSVFVGVTAYDYMLTLAGRLRPVDLDAYI
PTGNSANFAAGRLAYILGARGPAVVIDTACSSSLVAVHLACQSLRGRESDMALVGGTNLL
LSPGPSIACSRWGMLSPEGRCKTFDASADGYVRGEGAAVVVLKRLDDAVRDGNRILAVVR
GSAVNQDGASSGVTVPNGPAQQALLAKALTSSKLTAADIDYVEAHGTGTPLGDPIELDSL
SKVFSDRAGSDQLVIGSVKTNLGHLEAAAGVAGLMKAVLAVHNGYIPRHLNFHQLTPHAS
EAASRLRIAADGIDWPTTGRPRRAGVSSFGVSGTNAHVVIEQAPDPMAAAGTEPQRGPVP
AVSTLVVFGKTAPRVAATASVLADWLDGPGAAVPLADVAHTLNHHRARQTRFGTVAAVDR
RQAVIGLRALAAGQSAPGVVAPREGSIGGGTVFVYSGRGSQWAGMGRQLLADEPAFAAAI
AELEPEFVAQGGFSLRDVIAGGKELVGIEQIQLGLIGMQLALTALWRSYGVTPDAVIGHS
MGEVAAAVVAGALTPAQGLRVTAVRSRLMAPLSGQGTMALLELDAEATEALIADYPEVSL
GIYASPRQTVISGPPLLIDELIDKVRQQNGFATRVNIEVAPHNPAMDALQPAMRSELADL
TPQPPTIPIISTTYADLGISLGSGPRFDAEHWATNMRNPVRFHQAIAHAGADHHTFIEIS
AHPLLTHSISDTLRASYDVDNYLSIGTLQRDAHDTLEFHTNLNTTHTTHPPQTPHPPEPH
PVLPTTPWQHTQHWITATSAAYHRPDTHPLLGVGVTDPTNGTRVWESELDPDLLWLADHV
IDDLVVLPGAAYAEIALAAATDTFAVEQDQPWMISELDLRQMLHVTPGTVLVTTLTGDEQ
RCQVEIRTRSGSSGWTTHATATVARAEPLAPLDHEGQRREVTTADLEDQLDPDDLYQRLR
GAGQQHGPAFQGIVGLAVTQAGVARAQVRLPASARTGSREFMLHPVMMDIALQTLGATRT
ATDLAGGQDARQGPSSNSALVVPVRFAGVHVYGDITRGVRAVGSLAAAGDRLVGEVVLTD
ANGQPLLVVDEVEMAVLGSGSGATELTNRLFMLEWEPAPLEKTAEATGALLLIGDPAAGD
PLLPALQSSLRDRITDLELASAADEATLRAAISRTSWDGIVVVCPPRANDESMPDEAQLE
LARTRTLLVASVVETVTRMGARKSPRLWIVTRGAAQFDAGESVTLAQTGLRGIARVLTFE
HSELNTTLVDIEPDGTGSLAALAEELLAGSEADEVALRDGQRYVNRLVPAPTTTSGDLAA
EARHQVVNLDSSGASRAAVRLQIDQPGRLDALNVHEVKRGRPQGDQVEVRVVAAGLNFSD
VLKAMGVYPGLDGAAPVIGGECVGYVTAIGDEVDGVEVGQRVIAFGPGTFGTHLGTIADL
VVPIPDTLADNEAATFGVAYLTAWHSLCEVGRLSPGERVLIHSATGGVGMAAVSIAKMIG
ARIYTTAGSDAKREMLSRLGVEYVGDSRSVDFADEILELTDGYGVDVVLNSLAGEAIQRG
VQILAPGGRFIELGKKDVYADASLGLAALAKSASFSVVDLDLNLKLQPARYRQLLQHILQ
HVADGKLEVLPVTAFSLHDAADAFRLMASGKHTGKIVISIPQHGSIEAIAAPPPLPLVSR
DGGYLIVGGMGGLGFVVARWLAEQGAGLIVLNGRSAPSDEVAAAIAELNASGSRIEVITG
DITEPDTAERLVRAVEDAGFRLAGVVHSAMVLADEIVLNMTDSAARRVFAPKVTGSWRLH
VATAARDVDWWLTFSSAAALLGTPGQGAYAAANSWVDGLVAHRRSAGLPAVGINWGPWAD
VGRAQFFKDLGVEMINAEQGLAAMQAVLTADRGRTGVFSLDARQWFQSFPAVAGSSLFAK
LHDSAARKSGQRRGGGAIRAQLDALDAAERPGHLASAIADEIRAVLRSGDPIDHHRPLET
LGLDSLMGLELRNRLEASLGITLPVALVWAYPTISDLATALCERMDYATPAAAQEISDTE
PELSDEEMDLLADLVDASELEAATRGES*

Genomic Sequence

>Rv2933
ATGACCGCAGCGACACCAGATCGCCGAGCGATCATCACCGAGGCGCTGCACAAGATCGAT
GATCTCACGGCGCGCCTGGAAATCGCCGAAAAATCCAGCAGCGAACCGATCGCGGTGATC
GGCATGGGTTGCCGGTTCCCGGGCGGGGTCAACAACCCCGAACAGTTCTGGGATTTGTTG
TGCGCCGGCCGAAGCGGCATCGTCCGGGTTCCCGCGCAGCGGTGGGACGCCGACGCCTAC
TACTGTGATGATCACACCGTGCCGGGGACCATCTGCAGCACCGAAGGCGGTTTTCTCACC
AGCTGGCAGCCAGATGAGTTCGATGCGGAGTTCTTCTCAATCTCCCCGCGCGAAGCGGCG
GCGATGGACCCGCAGCAGCGATTGTTGATTGAAGTTGCGTGGGAAGCGCTAGAAGACGCG
GGCGTCCCGCAACACACCATTCGCGGTACGCAAACCTCGGTATTCGTCGGTGTCACCGCC
TACGACTACATGCTCACGCTGGCGGGCCGGCTACGACCTGTTGACCTCGACGCGTACATC
CCAACCGGGAACTCGGCGAACTTCGCCGCCGGACGGCTGGCCTACATCCTCGGGGCACGC
GGACCCGCGGTGGTCATCGACACGGCCTGCTCATCGTCGTTGGTGGCGGTGCACCTGGCA
TGCCAGAGCCTGCGCGGGCGGGAAAGCGATATGGCGTTGGTGGGTGGAACCAACCTTTTG
CTGAGCCCGGGACCCAGCATCGCTTGCTCGCGATGGGGGATGCTGTCACCGGAGGGGCGG
TGCAAGACCTTCGATGCGTCCGCCGATGGATACGTGCGCGGCGAGGGTGCCGCGGTGGTG
GTGCTCAAGCGGCTGGATGACGCGGTGCGCGACGGCAACCGCATTCTTGCCGTGGTACGC
GGTTCGGCGGTCAACCAGGACGGTGCCAGCAGCGGAGTGACCGTTCCCAACGGGCCAGCG
CAACAGGCGTTGCTCGCCAAAGCATTGACGTCGTCGAAGTTGACAGCGGCCGATATCGAC
TACGTCGAGGCCCATGGAACTGGTACTCCGCTGGGCGACCCGATCGAACTCGATTCACTG
AGTAAGGTTTTCAGCGATCGAGCGGGTTCGGATCAGTTGGTGATTGGATCGGTGAAGACC
AATCTCGGTCACCTGGAAGCGGCGGCCGGTGTCGCCGGGCTGATGAAAGCCGTGCTCGCG
GTACACAACGGCTACATTCCGCGGCATCTTAACTTCCACCAGCTGACACCACATGCAAGT
GAGGCCGCATCTCGGCTGAGGATCGCCGCCGATGGTATTGACTGGCCAACCACCGGTCGA
CCTCGCCGGGCGGGGGTGTCGTCGTTCGGCGTCAGTGGGACGAATGCACACGTGGTGATC
GAGCAGGCACCCGATCCGATGGCCGCTGCGGGAACGGAGCCGCAGCGCGGCCCCGTTCCC
GCGGTGTCGACGCTGGTGGTGTTCGGCAAGACCGCACCGCGGGTGGCTGCGACGGCATCG
GTGCTGGCAGATTGGCTGGACGGCCCCGGCGCGGCGGTGCCGCTGGCCGATGTCGCGCAC
ACCCTCAACCATCACCGGGCCCGTCAGACCAGGTTCGGCACGGTAGCCGCTGTCGATCGG
CGCCAAGCGGTGATCGGGTTACGCGCGCTGGCCGCGGGTCAATCCGCCCCCGGGGTGGTG
GCACCCCGCGAAGGCTCCATCGGAGGCGGCACGGTGTTCGTCTACTCGGGACGAGGATCG
CAGTGGGCCGGAATGGGGCGCCAACTGCTGGCCGACGAGCCGGCATTCGCCGCTGCCATC
GCCGAACTGGAGCCGGAATTCGTTGCTCAAGGCGGGTTTTCGCTGCGCGACGTGATCGCC
GGCGGAAAAGAGTTGGTTGGCATCGAACAGATCCAGCTGGGACTGATCGGGATGCAGCTG
GCGCTGACCGCGTTGTGGCGCTCATACGGCGTGACACCCGATGCGGTGATAGGTCACTCG
ATGGGCGAAGTGGCCGCCGCGGTGGTGGCCGGGGCGCTGACCCCGGCCCAGGGATTACGG
GTGACCGCGGTCCGGTCGAGGCTGATGGCGCCGCTGTCCGGGCAGGGCACGATGGCGTTG
CTGGAACTCGACGCCGAAGCCACTGAGGCGCTGATTGCCGACTACCCCGAGGTGAGCCTG
GGGATCTATGCCTCCCCACGCCAAACCGTGATTTCCGGGCCGCCGCTATTGATCGACGAG
CTCATCGACAAGGTGCGCCAACAGAACGGCTTCGCTACCCGAGTCAACATCGAGGTGGCC
CCCCACAACCCGGCCATGGATGCACTGCAACCGGCGATGCGTTCGGAATTGGCCGATCTC
ACCCCGCAACCGCCGACCATCCCGATCATCTCCACCACCTACGCCGACCTCGGCATTTCC
CTGGGTTCCGGCCCCAGGTTCGACGCCGAGCACTGGGCAACCAACATGCGCAACCCGGTA
CGGTTCCACCAGGCCATCGCTCATGCCGGCGCCGATCACCACACCTTCATCGAGATCAGC
GCCCACCCGCTGCTGACCCACTCGATCAGCGACACCCTGCGCGCCAGCTACGATGTCGAC
AACTATCTGAGCATCGGCACCTTGCAACGCGACGCTCACGACACCCTCGAGTTCCACACG
AACCTCAACACGACCCACACCACCCATCCCCCCCAGACTCCCCACCCCCCCGAACCCCAC
CCCGTGCTGCCCACCACCCCATGGCAGCACACCCAGCACTGGATCACCGCCACGTCGGCC
GCTTACCACAGGCCCGACACCCACCCGTTGCTTGGCGTCGGTGTCACCGACCCCACTAAC
GGCACCCGGGTTTGGGAAAGCGAGCTCGACCCTGATCTGCTGTGGCTCGCCGATCACGTC
ATCGACGATCTCGTTGTGCTGCCCGGGGCGGCCTACGCTGAGATCGCGCTGGCGGCCGCG
ACCGACACCTTCGCAGTCGAGCAAGATCAGCCCTGGATGATCAGCGAGCTCGACCTTCGG
CAGATGCTGCATGTGACCCCAGGCACCGTGTTGGTCACCACGCTCACCGGCGACGAGCAG
CGATGCCAGGTCGAAATACGCACCCGCAGCGGGTCTTCGGGATGGACCACCCACGCCACC
GCCACCGTTGCCCGCGCCGAGCCGTTAGCACCGCTGGATCACGAAGGACAGCGGCGCGAG
GTAACCACTGCCGACCTCGAGGACCAACTGGATCCCGACGACCTGTATCAGCGCCTGCGC
GGCGCCGGCCAACAGCACGGACCCGCGTTTCAAGGCATCGTGGGGCTGGCCGTCACGCAA
GCTGGCGTGGCCCGTGCGCAAGTACGGCTACCCGCATCGGCCAGAACGGGTTCCCGTGAG
TTCATGCTGCACCCGGTGATGATGGATATCGCGTTGCAGACACTGGGAGCCACCCGGACG
GCGACCGATCTGGCCGGCGGCCAGGACGCCCGGCAGGGCCCATCTTCCAACTCGGCCTTG
GTGGTACCGGTGCGTTTCGCCGGTGTCCACGTGTACGGCGATATCACCCGCGGGGTTCGC
GCGGTCGGCTCTCTGGCCGCAGCCGGTGACCGGCTGGTCGGCGAGGTAGTCCTGACCGAC
GCGAATGGCCAACCGCTGCTGGTCGTCGATGAAGTCGAGATGGCGGTGCTCGGATCCGGC
AGTGGCGCAACGGAACTCACCAACCGCCTATTCATGTTGGAGTGGGAGCCCGCACCGCTG
GAAAAGACCGCCGAGGCTACGGGTGCCCTGTTGCTGATCGGTGACCCCGCCGCGGGTGAC
CCGCTGCTGCCCGCGCTGCAGTCGTCGCTGCGCGACCGCATCACCGACCTCGAGCTGGCA
TCCGCGGCCGACGAAGCCACGCTGCGCGCGGCGATCAGCCGAACCTCCTGGGACGGGATC
GTTGTGGTCTGTCCGCCCCGAGCGAACGACGAATCGATGCCGGACGAGGCTCAACTGGAG
TTGGCACGCACACGCACGCTGCTGGTCGCCAGCGTGGTCGAGACCGTGACGCGAATGGGT
GCCCGCAAGAGCCCCCGACTGTGGATCGTCACCCGTGGCGCTGCACAGTTCGACGCAGGC
GAGTCGGTCACGTTGGCGCAGACCGGCCTACGTGGCATCGCACGGGTGCTGACATTTGAG
CATTCGGAGTTGAATACCACCCTCGTAGATATCGAACCGGACGGCACCGGCTCGCTGGCC
GCCCTGGCCGAGGAGTTGCTTGCCGGTTCCGAGGCCGACGAGGTCGCCTTGCGCGACGGT
CAACGCTATGTCAACCGGCTGGTGCCCGCACCCACCACGACCAGTGGTGATCTCGCCGCC
GAAGCTCGCCACCAGGTGGTGAACCTGGACAGCTCGGGCGCTTCCAGGGCAGCTGTCCGA
CTGCAGATCGATCAACCCGGACGGCTGGACGCACTAAACGTTCACGAGGTGAAACGGGGC
AGACCGCAAGGCGATCAAGTCGAGGTTCGCGTCGTCGCCGCCGGACTCAACTTCAGCGAC
GTGCTCAAAGCGATGGGCGTGTATCCGGGACTCGACGGTGCCGCGCCGGTGATCGGCGGC
GAATGTGTCGGCTACGTGACGGCCATCGGTGACGAGGTTGACGGCGTCGAGGTCGGACAG
CGAGTTATCGCATTCGGCCCTGGCACATTCGGGACCCATCTGGGGACCATCGCCGATCTC
GTCGTCCCAATTCCGGACACGCTAGCCGACAACGAGGCGGCCACGTTCGGCGTCGCCTAT
CTCACCGCCTGGCACTCGCTGTGCGAGGTCGGGCGCCTATCCCCCGGCGAACGCGTGCTC
ATCCATTCCGCCACCGGCGGTGTTGGAATGGCGGCGGTCTCGATCGCGAAGATGATCGGC
GCCCGCATCTACACGACGGCCGGTTCGGACGCCAAACGGGAAATGCTTTCCAGGCTCGGT
GTCGAGTACGTCGGCGACTCGCGAAGCGTGGATTTCGCTGACGAGATCCTCGAGCTGACA
GACGGCTACGGTGTGGACGTCGTTCTCAATTCGCTGGCGGGCGAGGCGATTCAACGCGGC
GTGCAGATCCTTGCGCCCGGTGGCCGGTTCATCGAACTGGGCAAGAAGGACGTCTACGCC
GATGCCAGCTTGGGCTTGGCCGCGCTAGCCAAGAGCGCGTCCTTCTCCGTGGTCGACCTC
GACCTGAATCTCAAGCTGCAGCCGGCGCGCTACCGCCAACTCCTGCAACACATCCTGCAG
CACGTGGCGGATGGCAAACTCGAGGTACTTCCCGTCACCGCATTTAGCCTGCACGATGCG
GCCGACGCATTCCGGCTTATGGCATCCGGTAAACACACCGGCAAGATCGTCATCTCGATA
CCCCAGCACGGCAGCATCGAGGCGATCGCTGCCCCGCCACCACTTCCTCTGGTCAGCCGC
GACGGCGGCTACCTCATCGTCGGCGGTATGGGTGGTCTCGGATTCGTCGTCGCGCGCTGG
CTGGCTGAGCAAGGTGCGGGACTGATTGTCCTCAACGGACGCTCGGCCCCCAGCGACGAG
GTGGCAGCCGCTATCGCGGAGCTGAACGCCTCCGGTAGCCGGATCGAGGTGATCACCGGC
GACATCACCGAGCCAGACACCGCCGAGCGGCTGGTGCGGGCGGTCGAAGACGCCGGGTTC
CGGCTGGCCGGGGTGGTGCACAGCGCGATGGTTCTCGCCGACGAGATCGTGTTGAACATG
ACCGATTCCGCCGCTCGGCGAGTGTTCGCCCCGAAGGTCACCGGCAGCTGGCGGCTTCAT
GTGGCCACCGCCGCGCGCGACGTCGACTGGTGGCTGACCTTCTCCTCGGCCGCCGCGCTG
CTGGGCACTCCCGGGCAGGGCGCGTACGCCGCCGCCAACTCGTGGGTCGACGGCCTGGTC
GCGCATCGGCGCTCGGCCGGACTTCCCGCTGTCGGGATCAACTGGGGCCCGTGGGCCGAC
GTTGGACGCGCGCAGTTCTTCAAAGACCTCGGGGTGGAGATGATCAACGCCGAGCAGGGG
CTTGCCGCCATGCAGGCGGTACTCACCGCCGATCGCGGGCGCACCGGTGTGTTCAGCCTC
GACGCGCGGCAGTGGTTCCAATCGTTCCCCGCTGTGGCGGGGTCCTCGCTGTTCGCGAAG
CTGCATGACTCGGCGGCCCGCAAAAGTGGGCAGCGGCGCGGCGGGGGCGCGATTCGCGCT
CAGCTAGACGCCCTCGACGCGGCCGAACGCCCAGGCCACCTCGCGTCCGCGATCGCCGAC
GAGATCCGTGCGGTGCTGCGCTCAGGCGATCCCATCGATCACCACCGACCGCTGGAAACC
CTGGGACTCGACTCGCTGATGGGCCTGGAATTGCGCAATCGGCTGGAAGCAAGTCTGGGC
ATCACGTTGCCGGTCGCGTTGGTGTGGGCATACCCGACGATCAGCGATCTCGCGACCGCC
CTGTGCGAACGAATGGACTACGCGACACCCGCGGCTGCGCAGGAGATTTCCGATACAGAA
CCCGAACTGTCCGACGAGGAGATGGATTTGCTCGCCGATCTGGTTGACGCCAGCGAGCTG
GAAGCTGCGACGCGAGGCGAGTCATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:PREPTHS2 phenolic phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 A. Rao & A. Ranganathan Interaction studies on proteins encoded by the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Mol. Genet. Genomics 2004
Term	TBRXN:PREPTHS2 phenolic phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,AK. Azad,TD. Sirakova,ND. Fernandes,PE. Kolattukudy Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria. J. Biol. Chem. 1997
Term	TBRXN:PREPTHS2 phenolic phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,DE. Minnikin,L. Kremer,LG. Dover,GS. Besra The methyl-branched fortifications of Mycobacterium tuberculosis. Chem. Biol. 2002
Term	TBRXN:PREPTHS phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 A. Rao & A. Ranganathan Interaction studies on proteins encoded by the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Mol. Genet. Genomics 2004
Term	TBRXN:PREPTHS phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,AK. Azad,TD. Sirakova,ND. Fernandes,PE. Kolattukudy Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria. J. Biol. Chem. 1997
Term	TBRXN:PREPTHS phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,DE. Minnikin,L. Kremer,LG. Dover,GS. Besra The methyl-branched fortifications of Mycobacterium tuberculosis. Chem. Biol. 2002
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2938	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2937	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2936	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2932	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2931	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2938	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2937	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2936	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2932	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2931	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	Regulatory Rv3692	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv3416	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv2745c	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv2034	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv0445c	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv0117	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv3692	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv3416	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv2745c	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv2034	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv0445c	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv0117	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	PhysicalInteraction Rv2932	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2932	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2931	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2931	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	RegulatedBy Rv3911	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. S. Raman, X. Puyang et al. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv3692	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv3416	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv2745c	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv1956	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv1359	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0445c	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0117	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Name	Type 1 polyketide synthase responsible with PpsA-B-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively	active	mjackson	2012-10-05
	Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	Type 1 polyketide synthase responsible with PpsA-B-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively (phenotypic [mycobacterial recombinant strains]) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	Type 1 polyketide synthase responsible with PpsA-B-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively (phenotypic [mycobacterial recombinant strains]) authors,AK. Azad,TD. Sirakova,ND. Fernandes,PE. Kolattukudy Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria. J. Biol. Chem. 1997
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay P. Constant, E. Perez et al. Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene. J. Biol. Chem. 2002